Dose-dependent relationship of polymeric hydrogels on motility and vitality of human spermatozoa in vitro

Abstract

Alteration in motility and vitality of human spermatozoa treated with various polymeric hydrogels in vitro has been studied. Different copolymers of acrylic acid-comethylmethacrylate, poly (AA-co-MMA); acrylic acid-co-butylacrylate, poly (AA-co-BA); Itaconic acid-co-methylmethacrylate, poly (IA-co-MMA); styrene maleic anhydride, poly (SMA) and homo-polymers of polyacrylic acid, poly (AA); poly methylmethacrylate, poly (MMA) were taken. Of all the polymers studied, the following three groups of waterinsoluble polymers, namely poly(IA-co-MMA), poly(AA-co-MMA) and poly (AA-co-BA) proved to be strong inhibitors of spermatozoa motility and vitality. The homopolymer of acrylic acid which is water soluble, also exhibited strong inhibitory action. Poly (MMA) did not show any such effects.

Poly(N,N,N-trimethylammoniumalkyl acrylamide chloride) Based Hydrogels for Serum Cholesterol Reduction

“…They have come to enjoy wide use as absorbents and in a variety of household applications . They are also used as drug delivery vehicles, in contact lenses, artificial organs and limbs, and various pharmaceutical applications. − …”

“…22 They are also used as drug delivery vehicles, in contact lenses, artificial organs and limbs, and various pharmaceutical applications. [23][24][25][26] It is convenient to imagine that hydrogels are composed of uniformly cross-linked or branched polymers yielding a homogeneous network bearing charge. More realistic is to accept that real hydrogels have many defects: heterodispersity of the chain lengths, as well as loops, loose ends, entanglements, and interpenetrating networks.…”