Phase II clinical trial of a vas deferens injectable contraceptive for the male

Guha, Sujoy K.; Singh, Gurjot; Ansari, Shirfuddin; Vuyyuru, Sudheer K.; Srivastava, A. K.; Koul, Veena; Das, Hem Chandra; Malhotra, Ritu; Das, Subodh K.

doi:10.1016/s0010-7824(97)00142-x

Cited by 76 publications

(61 citation statements)

References 7 publications

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“…32,33 RISUG is presently undergoing extended phase III clinical trials in India 2,34 after successfully completing phase I and phase II trials. 33,[35][36][37] The presence of common parent component SMA in Smart RISUG ensures long-term safety and safe reversibility of the drug.…”

Section: Discussionmentioning

confidence: 99%

Smart RISUG: A potential new contraceptive and its magnetic field-mediated sperm interaction

Jha¹,

Jha²,

Guha³

2009

IJN

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Abstract:The rationale and technique underlying a novel concept of noninvasive fertility control by a new Cuproferrogel contraceptive drug, iron oxide-copper-styrene maleic anhydride-dimethyl sulphoxide (Fe 3 O 4 -Cu-SMA-DMSO) composite named 'Smart RISUG' (smart reversible inhibition of sperm under guidance) in presence of pulsed magnetic fi eld (PMF; 1 mT to 800 mT) is explained. It was synthesized by dispersing iron oxide particles and copper particles into SMA-DMSO (male contraceptive RISUG) and characterized for particle distribution, particle size measurement and transmittance peaks, etc. Interaction of the RISUG particles as well as Smart RISUG particles with Albino rat sperm cell was studied in presence as well as absence of PMF. To fi nd an explanation to increased reaching of the Smart RISUG drug into sperm under infl uence of magnetic fi eld, the transport properties were characterized by high resolution transmission electron microscopy and atomic force microscopy. Smart RISUG could be mobilized into sperm cell membrane at the PMF, 760 mT in about 50 seconds. Adoption of novel drug Smart RISUG involving new technique may open the pathway for non surgical control of drug distribution, detection and restoration of the normal fertility after removal of the contraceptive from the male/female reproductive tube in presence of electromagnetic fi eld.

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Section: Discussionmentioning

confidence: 99%

Smart RISUG: A potential new contraceptive and its magnetic field-mediated sperm interaction

Jha¹,

Jha²,

Guha³

2009

IJN

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“…Products that can be used to achieve nonsurgical sterilization of women include liquids, coils, plugs, and chemical irritants (Table 3). For males, recent alternatives to vasectomy are aimed at improved reversibility (42) and include implants and gels (Table 3) (43)(44)(45).…”

Section: Retrospectmentioning

confidence: 99%

As the world grows: contraception in the 21st century

Aitken¹,

Baker²,

Doncel³

et al. 2008

J. Clin. Invest.

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Contraceptives that are readily available and acceptable are required in many poorer countries to reduce population growth and in all countries to prevent maternal morbidity and mortality arising from unintended pregnancies. Most available methods use hormonal steroids or are variations of barrier methods. Reports from several fora over the last 12 years have emphasized the number of unwanted pregnancies and resultant abortions, which indicate an unmet need for safe, acceptable, and inexpensive contraceptive methods. This unmet need can be assuaged, in part, by development of new nonhormonal contraceptive methods. This Review addresses the contribution that the "omic" revolution can make to the identification of novel contraceptive targets, as well as the progress that has been made for different target molecules under development.

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“…Earlier experiments conducted on albino rats proved spermicidal activity of RISUG and its non-toxicity [1,2] and teratogenic safety [3] have also confirmed. After injecting RISUG, as sperm come into contact with the polymer, the positive and the negative charges on the polymer surface causes significant damage to the acrosome and its content and causes the surface of sperm burst, making it immotile and incapable to fertilize an egg [4][5][6]. RISUG-M is an advancement of the contraceptive RISUG and consist of a co-polymer styrene maleic anhydride (SMA), magnetic particles: iron oxide (8-12%), electrically conductive particles: copper (3-8%) dissolved in 99% pure dimethylsulphoxide (DMSO) [7].…”

Section: Introductionmentioning

confidence: 99%