Poly(N,N,N-trimethylammoniumalkyl acrylamide chloride) Based Hydrogels for Serum Cholesterol Reduction

Abstract

Hydrogels present an attractive alternative to nanoscale block copolymer aggregates and microscale resin beads as potential asystemic serum cholesterol reduction materials. Not only would the oral delivery of these materials be more pleasant than the sand-like bile salt anion sequestrant beads but also the hydrogel preparation is much simpler than the copolymer aggregate analogues [Cameron, N. S.; Eisenberg, A.; Brown, G. R. Biomacromolecules 2002, 3, 116-123. Cameron, N. S.; Eisenberg, A.; Brown, G. R. Biomacromolecules 2002, 3, 124-132]. Our goal was to explore these materials building on our experience with bulk resins and self-assembled copolymers. In this paper, following a brief introduction to hydrogels and their application to hypercholesterolemia, the synthesis, characterization, and preliminary glycocholate binding properties of poly(N,N,N-trimethylammoniumalkyl acrylamide chloride)gel are presented [Cameron, N. S.; Eisenberg, A.; Brown, G. R. Polym. Preprints 2002, 43, 771-772].

Novel bile acid sequestrant: A biodegradable hydrogel based on amphiphilic allylamine copolymer

“…7,8 Moreover, BAS is an established therapeutic regimen also used for treating hypercholesterolemia with recognized safety owing to its biocompatibility and suitable mechanical properties. [9][10][11][12][13][14][15] Usually, BAS is a polymeric cationic resin which binds bile acid salts in gastrointestinal (GI) tract, breaks the bile acid enterohepatic circulation, and resists to reabsorption. The organism response leads to cholesterol consumption, which reduces the serum cholesterol levels.…”

Computational modeling and molecular imprinting for the development of acrylic polymers with high affinity for bile salts

“…The results obtained with natural and synthetic polymers indicate that a bile acid sequestrant should meet the following features [12][13][14][15]: i) to posses cationic groups that enable a fast interaction with bile salts; ii) to contain hydrophobic groups to enhance the stability of the complexes; and iii) to swell to a certain extent to make the network accessible to the bile salt. Molecular imprinting technology has been tested as tool to optimize performances of selective traps [16][17][18].…”