Novel bile acid sequestrant: A biodegradable hydrogel based on amphiphilic allylamine copolymer

Wang, Xin; Jing, Shiyao; Qiu, Xiumin; Zhao, Shile; Liu, Yusheng; Tan, Yang

doi:10.1016/j.cej.2016.06.104

Cited by 19 publications

(6 citation statements)

References 57 publications

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“…Therefore, the parameters calculated with these models can be used to evaluate the adsorption mechanism. For example, the good fitting of the experimental data to Langmuir model confirmed the homogeneous monolayer adsorbtion of NaCA by dextran-based hydrogels, what was also observed for other bile acid-sorbent systems [39][40][41][42]. Langmuir constant values (KL) are associated to the affinity between bile acid salt and gels.…”

Section: Adsorption Isothermssupporting

confidence: 74%

Adsorption of Sodium Cholate on Cationic Dextran Gels: Comparison of Isotherm Binding Models

Stanciu¹,

Nichifor²,

Anca-Irina³

2021

Mater. Plast.

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Cationic dextran hydrogels having pendent 51-59 mol% N-alkyl-N,N-dimethylammonium chloride groups were synthesized and tested as adsorbents for sodium cholate. The bile acid salt sorption by these gels was evaluated by equilibrium analysis in water and 10 mM NaCl solution. The best adsorption results were obtained with amphiphilic dextran-based gels having two types of pendant ammonium chloride groups with different polarities. Experimental adsorption data for all polymers fitted good with Langmuir, Dubinin-Raduskevich and Temkin models over the entire range of ligand concentrations. The maximum experimental adsorption capacity of dextran sorbents for sodium cholate was in the range 850-1075 mg/g.

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Section: Adsorption Isothermssupporting

confidence: 74%

Adsorption of Sodium Cholate on Cationic Dextran Gels: Comparison of Isotherm Binding Models

Stanciu¹,

Nichifor²,

Anca-Irina³

2021

Mater. Plast.

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“…An amphiphilic copolymer ( Figure 12 ) synthesized by copolymerization of allylamine hydrochloride with allylhexylamine hydrochloride was cross-linked with a double aldehyde obtained by the oxidation of methyl-D-glucopyranoside by sodium periodate [ 99 ]. A molar ratio between allylamine hydrochloride and allylhexylamine hydro- chloride of 90.6/9.4 and a weight percentage of 2.75 wt% for the cross-linker allowed the obtaining of the double Schiff base cross-linked hydrogel with the optimal composition for sodium glycocholate adsorption.…”

Section: Lipid-lowering Drugsmentioning

confidence: 99%

Bile Acid Sequestrants Based on Natural and Synthetic Gels

Stanciu¹,

Nichifor²,

Teacă³

2023

Gels

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Bile acid sequestrants (BASs) are non-systemic therapeutic agents used for the management of hypercholesterolemia. They are generally safe and not associated with serious systemic adverse effects. Usually, BASs are cationic polymeric gels that have the ability to bind bile salts in the small intestine and eliminate them by excretion of the non-absorbable polymer–bile salt complex. This review gives a general presentation of bile acids and the characteristics and mechanisms of action of BASs. The chemical structures and methods of synthesis are shown for commercial BASs of first- (cholestyramine, colextran, and colestipol) and second-generation (colesevelam and colestilan) and potential BASs. The latter are based on either synthetic polymers such as poly((meth)acrylates/acrylamides), poly(alkylamines), poly(allylamines) and vinyl benzyl amino polymers or biopolymers, such as cellulose, dextran, pullulan, methylan, and poly(cyclodextrins). A separate section is dedicated to molecular imprinting polymers (MIPs) because of their great selectivity and affinity for the template molecules used in the imprinting technique. Focus is given to the understanding of the relationships between the chemical structure of these cross-linked polymers and their potential to bind bile salts. The synthetic pathways used in obtaining BASs and their in vitro and in vivo hypolipidemic activities are also introduced.

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“…In this polymer, the amino (and correspondingly the ammonium) content is the highest. This polymer will be used in future as a bile acid sequestrant to control hypercholesterolemia (Lopez-Jaramillo et al 2015; Wang et al 2016). The toxicological study with different doses administered orally in mice was conducted by the Miller-Tainter method (Randhawa 1944;Kasolo et al 2011).…”

Section: Acute Toxicitymentioning

confidence: 99%

Ammonium salts of microcrystalline cellulose-g-poly(acrylonitrile): toxicity, antioxidant and anti-inflammatory properties

Kenawy

Khattab

Tenhu

et al. 2023

Preprint

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Cellulose is an excellent starting material for the construction of bioactive polymers. In the present work, we have synthesized quaternized graft copolymers of cellulose and tested their biological properties. Cellulose was grafted with acrylonitrile in a cerium ion catalyzed reaction. High yield of the grafting reaction, 89%, was achieved. Next, the poly (acrylonitrile) chains were aminated using three different amines and finally, the amino functions were quaternized using methyl iodide. In addition to chemical and physical characterization of the polymers, several tests on their bioactive properties have been conducted. The polymers turned out to have good antioxidant properties, as assessed studying how they scavenge ABTS radicals. Anti-inflammatory properties were investigated by a membrane stabilization method. The results showed that the quaternized polymers had anti-inflammatory effects and the one aminated with tris(2-aminoethyl)amine was the most significant compared with indomethacin. The cytotoxicity was evaluated in vitro against HepG2 and WI-38 cell lines. All quaternized polymers showed moderate effects against the cancerous cell line HEPG2. On the other hand, their effect against normal fibroblast WI-38 was weak. The acute toxicity in vivo was evaluated for one of the polymers, for which the LD50 was 6606 mg/kg. The high LD50 indicates the polymer is relatively non-toxic, and will be considered in future for in vivo studies.

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Novel bile acid sequestrant: A biodegradable hydrogel based on amphiphilic allylamine copolymer

Cited by 19 publications

References 57 publications

Adsorption of Sodium Cholate on Cationic Dextran Gels: Comparison of Isotherm Binding Models

Adsorption of Sodium Cholate on Cationic Dextran Gels: Comparison of Isotherm Binding Models

Bile Acid Sequestrants Based on Natural and Synthetic Gels

Ammonium salts of microcrystalline cellulose-g-poly(acrylonitrile): toxicity, antioxidant and anti-inflammatory properties

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