Dosage du mercure plasmatique par ICP-MS. Concentrations usuelles chez 53 sujets volontaires

Goullé, Jean-Pierre; Mahieu, Loïc; Saussereau, Élodie; Lacroix, Christian

doi:10.1051/ata:2008007

Cited by 7 publications

(6 citation statements)

References 6 publications

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“…For chromium and vanadium, the collision cell was not available at this period of time. A specific method was subsequently developed for plasma mercury owing to a memory effect in this matrix (18). Owing to unsuitable vials, plasma lead was not measured in this latter study.…”

Section: Resultsmentioning

confidence: 99%

“…For vanadium and chromium determination, a collision cell technology was used (ICP -MS-CCT), as recently described (17). Owing to a memory effect in the torch, plasma mercury was quantified separately using a specific technique (18). The limit of quantification (LOQ) was performed again on ultrapure reagent blanks based on the usual criteria for LOQ of 10 blank standard deviation.…”

Section: Methodsmentioning

confidence: 99%

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Metallic Profile of Whole Blood and Plasma in a Series of 106 Healthy Volunteers

Cesbron

Saussereau

Mahieu

et al. 2013

Journal of Analytical Toxicology

101

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In 2003, we simultaneously quantified 27 metals by inductively coupled plasma-mass spectrometry (ICP-MS) in the whole blood, plasma and urine of 100 healthy volunteers. We again determined the metallic profile in whole blood and plasma during 2012. ICP-MS validated multielementary method was performed for metals in whole blood and plasma. Whole blood vanadium and chromium were quantified using ICP-MS collision cell technology. The aims of the study were to compare and assess any changes in this profile, particularly due to the environment. Healthy male/female staff volunteers (n = 106) with no professional exposure to metals, or medication containing lithium, strontium; or food supplements with trace elements and vitamins and with no metal prosthesis were included. Tobacco consumption and the number of dental amalgams were recorded. Our results demonstrated a blood lead level that had drastically decreased, i.e. reduced by half, during this period (12.5 versus 26.3 µg/L, P < 0.0001). Known differences were observed between males and females for copper and zinc; cadmium and lead were higher in smokers. Median plasmatic mercury, a specific test for dental amalgam exposure, did not significantly increase (0.38 versus 0.28 µg/L, P = 0.11). The ICP-MS metallic profile is a very practical concept that is useful for clinical, forensic and environmental toxicology, including industrial hygiene monitoring.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Metallic Profile of Whole Blood and Plasma in a Series of 106 Healthy Volunteers

Cesbron

Saussereau

Mahieu

et al. 2013

Journal of Analytical Toxicology

101

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“…Ceci améliore de manière importante la spécificité de la mesure, surtout dans le sang total. Quant au mercure plasmatique rappelons qu'il s'agit du seul dosage qui n'est pas réalisé en mode multiélé-mentaire [2]. Enfin, la détermination du brome dans le plasma et le sang total est semi-quantitative.…”

Section: Discussionunclassified

Dosage multiélémentaire dans le plasma et le sang total par ICP-MS : influence du matériel de prélèvement

et al. 2008

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“…To explore mercury exposure linked to dental amalgam it is essential to analyze the plasmatic mercury that reflects mineral mercury by using an individual ICP-MS specific test, whereas whole blood mercury, included in the multi-elemental panel, is linked to seafood intake containing MeHg [74]. Nevertheless, the European Scientific Committee on Emerging and Newly Identified Health Risks (SCENIHR), in their report regarding the safety of dental amalgam, have concluded that the use of mercury for dental restoration was safe: "However, with respect to the debate about the possibility of causal relationships between the use of mercurycontaining amalgam and a wide variety of adverse systemic health effects and taking into account many studies and investigations into this putative causal link, there is no unequivocal evidence to support this possibility" [75];…”

Section: Normal Multi-elemental Values In Biological Fluidsmentioning

confidence: 99%

Current Role of ICP–MS in Clinical Toxicology and Forensic Toxicology: A Metallic Profile

et al. 2014

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As metal/metalloid exposure is inevitable owing to its omnipresence, it may exert toxicity in humans. Recent advances in metal/metalloid analysis have been made moving from flame atomic absorption spectrometry and electrothermal atomic absorption spectrometry to the multi-elemental inductively coupled plasma (ICP) techniques as ICP atomic emission spectrometry and ICP-MS. ICP-MS has now emerged as a major technique in inorganic analytical chemistry owing to its flexibility, high sensitivity and good reproducibility. This in depth review explores the ICP-MS metallic profile in human toxicology. It is now routinely used and of great importance, in clinical toxicology and forensic toxicology to explore biological matrices, specifically whole blood, plasma, urine, hair, nail, biopsy samples and tissues.

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Dosage du mercure plasmatique par ICP-MS. Concentrations usuelles chez 53 sujets volontaires

Cited by 7 publications

References 6 publications

Metallic Profile of Whole Blood and Plasma in a Series of 106 Healthy Volunteers

Metallic Profile of Whole Blood and Plasma in a Series of 106 Healthy Volunteers

Dosage multiélémentaire dans le plasma et le sang total par ICP-MS : influence du matériel de prélèvement

Current Role of ICP–MS in Clinical Toxicology and Forensic Toxicology: A Metallic Profile

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