Current Role of ICP–MS in Clinical Toxicology and Forensic Toxicology: A Metallic Profile

Goullé, Jean-Pierre; Saussereau, Élodie; Mahieu, Loïc; Guerbet, Michel

doi:10.4155/bio.14.190

Cited by 43 publications

(14 citation statements)

References 91 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, 'absence of evidence is not evidence of absence' [13]. Aluminium is one of the most challenging elements to detect and quantify at trace levels by ICP-MS, with LLOQs similar to our assay reported elsewhere [14,15]. As such, with no apparent systemic exposure of aluminium which may have been a result of the concentrations being below our limit of detection for aluminium by ICP-MS, the investigation Analysis of aluminium in rat following administration of either aluminium or MCT-based adjuvants Research Article focused on whether any so far undetectable systemic aluminium had accumulated in rat kidney, the major organ for aluminium elimination [16] or in rat brain.…”

Section: Resultssupporting

confidence: 62%

Analysis of Aluminium in Rat Following Administration of Allergen Immunotherapy Using Either Aluminium or Microcrystalline-Tyrosine-Based Adjuvants

McDougall¹,

Heath

Krämer

et al. 2016

Bioanalysis

View full text Add to dashboard Cite

Background: Investigation into the absorption, distribution and elimination of aluminium in rat after subcutaneous aluminium adjuvant formulation administration using ICP-MS is described. Method & results: Assays were verified under the principles of a tiered approach. There was no evidence of systemic exposure of aluminium, in brain or in kidney. Extensive and persistent retention of aluminium at the dose site was observed for at least 180 days after administration. Conclusion: This is the first published work that has quantified aluminium adjuvant retention based on the quantity of aluminium delivered in a typical allergy immunotherapy course. The results indicate that the repeated administration of aluminium-containing adjuvants will likely contribute directly and significantly to an individual's body burden of aluminium.

show abstract

Section: Resultssupporting

confidence: 62%

Analysis of Aluminium in Rat Following Administration of Allergen Immunotherapy Using Either Aluminium or Microcrystalline-Tyrosine-Based Adjuvants

McDougall¹,

Heath

Krämer

et al. 2016

Bioanalysis

View full text Add to dashboard Cite

show abstract

“…ICP-MS is used in environmental research [108], infant and adult nutrition [66,109,110], as well as the analysis of drugs and pharmaceuticals, medicinal plants and supplements [95]. Furthermore, ICP-MS based multi-elemental monitoring has applications in medicine including toxicology [111], occupational health [76], and is being developed for clinical diagnostics and monitoring [112,113]. Currently, there are more than 40 clinical laboratory blood tests for individual elements in human blood and other fluids and most of them use ICP-MS.…”

Section: Conclusion and Discussionmentioning

confidence: 99%

Elemental metabolomics

2017

View full text Add to dashboard Cite

Elemental metabolomics is quantification and characterization of total concentration of chemical elements in biological samples and monitoring of their changes. Recent advances in inductively coupled plasma mass spectrometry have enabled simultaneous measurement of concentrations of > 70 elements in biological samples. In living organisms, elements interact and compete with each other for absorption and molecular interactions. They also interact with proteins and nucleotide sequences. These interactions modulate enzymatic activities and are critical for many molecular and cellular functions. Testing for concentration of > 40 elements in blood, other bodily fluids and tissues is now in routine use in advanced medical laboratories. In this article, we define the basic concepts of elemental metabolomics, summarize standards and workflows, and propose minimum information for reporting the results of an elemental metabolomics experiment. Major statistical and informatics tools for elemental metabolomics are reviewed, and examples of applications are discussed. Elemental metabolomics is emerging as an important new technology with applications in medical diagnostics, nutrition, agriculture, food science, environmental science and multiplicity of other areas.

show abstract

“…Forty seven heavy metals and microelements (Li, Be, B, Na, Mg, Al, Si, P, S, K, Ca, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Ga, Ge, As, Se, Rb, Sr , Zr, Nb, Mo, Ru, Rh, Pd, Ag, Cd, Sn, Sb, Te, Cs, Ba, Hf, Ta, W, Re, Pt, Au, Hg, Tl, Pb, U) were analyzed by the ICP-MS technique in hair of PERM and control rats. This validated method is widely used to analyze heavy metals and microelements [ 18 , 19 ]. Hair samples were cut into small pieces using clean stainless steel scissors.…”

Section: Methodsmentioning

confidence: 99%

Metal and Microelement Biomarkers of Neurodegeneration in Early Life Permethrin-Treated Rats

Nasuti

Ferraro

Giovannetti

et al. 2016

Toxics

View full text Add to dashboard Cite

Abstract:Hair is a non-invasive biological material useful in the biomonitoring of trace elements because it is a vehicle for substance excretion from the body, and it permits evaluating long-term metal exposure. Here, hair from an animal model of neurodegeneration, induced by early life permethrin treatment from the sixth to 21th day of life, has been analyzed with the aim to assess if metal and microelement content could be used as biomarkers. A hair trace element assay was performed by the ICP-MS technique in six-and 12-month-old rats. A significant increase of As, Mg, S and Zn was measured in the permethrin-treated group at 12 months compared to six months, while Si and Cu/Zn were decreased. K, Cu/Zn and S were increased in the treated group compared to age-matched controls at six and 12 months, respectively. Cr significantly decreased in the treated group at 12 months. PCA analysis showed both a best difference between treated and age-matched control groups at six months. The present findings support the evidence that the Cu/Zn ratio and K, measured at six months, are the best biomarkers for neurodegeneration. This study supports the use of hair analysis to identify biomarkers of neurodegeneration induced by early life permethrin pesticide exposure.

show abstract

Current Role of ICP–MS in Clinical Toxicology and Forensic Toxicology: A Metallic Profile

Cited by 43 publications

References 91 publications

Analysis of Aluminium in Rat Following Administration of Allergen Immunotherapy Using Either Aluminium or Microcrystalline-Tyrosine-Based Adjuvants

Analysis of Aluminium in Rat Following Administration of Allergen Immunotherapy Using Either Aluminium or Microcrystalline-Tyrosine-Based Adjuvants

Elemental metabolomics

Metal and Microelement Biomarkers of Neurodegeneration in Early Life Permethrin-Treated Rats

Contact Info

Product

Resources

About