Metallic Profile of Whole Blood and Plasma in a Series of 106 Healthy Volunteers

Abstract

In 2003, we simultaneously quantified 27 metals by inductively coupled plasma-mass spectrometry (ICP-MS) in the whole blood, plasma and urine of 100 healthy volunteers. We again determined the metallic profile in whole blood and plasma during 2012. ICP-MS validated multielementary method was performed for metals in whole blood and plasma. Whole blood vanadium and chromium were quantified using ICP-MS collision cell technology. The aims of the study were to compare and assess any changes in this profile, particularly due to the environment. Healthy male/female staff volunteers (n = 106) with no professional exposure to metals, or medication containing lithium, strontium; or food supplements with trace elements and vitamins and with no metal prosthesis were included. Tobacco consumption and the number of dental amalgams were recorded. Our results demonstrated a blood lead level that had drastically decreased, i.e. reduced by half, during this period (12.5 versus 26.3 µg/L, P < 0.0001). Known differences were observed between males and females for copper and zinc; cadmium and lead were higher in smokers. Median plasmatic mercury, a specific test for dental amalgam exposure, did not significantly increase (0.38 versus 0.28 µg/L, P = 0.11). The ICP-MS metallic profile is a very practical concept that is useful for clinical, forensic and environmental toxicology, including industrial hygiene monitoring.

Maternal exposure to alkali, alkali earth, transition and other metals: Concentrations and predictors of exposure

“…The median blood strontium concentrations in this study were higher than those reported by Cesbron et al (2013) reporting median concentrations for adults of 14.5 mg/L with a range of 8.2e35.0 mg/L. Strontium does not readily cross the placenta and hence is considered not a significant risk for the foetus except where there may be very high concentrations (ATSDR, 2004b).…”

Current Role of ICP–MS in Clinical Toxicology and Forensic Toxicology: A Metallic Profile

“…ICP-MS not only allows individual element analysis but also the simultaneous determination of approximately 30 elements of toxicological interest in a single run. Furthermore, this approach permits an optimal gain in sensitivity in all biological matrices: specifically, whole blood, plasma or serum, red cells, urine, hair, nail, biopsy samples or tissues [2,[27][28][29]. The LOQ is very low as it ranges from 2 ng/l for uranium to 700 ng/l for selenium in plasma for a 25 multi-element analysis [27] and from 0.2 ng/g for platinum, thallium and uranium to 500 ng/g for boron in nail for a 32 multi-element analysis [28].…”

Les prothèses de hanche au cobalt sont-elles dangereuses ?

“…Également, le pourcentage de résultats supérieurs au seuil recommandé (18,7 %) que nous avons obtenu est équivalent à celui rapporté dans une étude similaire [39]. En comparaison, chez 106 volontaires sains ne portant pas de prothèse [40], la valeur de la cobaltémie a été estimée entre 0,20 μg/l (5 e percentile) et 0,63 μg/l (95 e percentile), confirmant ainsi que la concentration sanguine de cobalt est significativement plus basse dans la population générale que dans la population des patients avec PHM.…”