Doppler waveform of the hepatic veins in an obese population

Karabulut, Nevzat; Kazil, Selcuk; Yagci, Baki; Sabir, Nuran

doi:10.1007/s00330-004-2423-0

Cited by 29 publications

(80 citation statements)

References 16 publications

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“…All the subjects in the study and control groups were negative for hepatitis B surface antigen and anti-hepatitis C virus antibody. To preclude possible influences on the waveform of the vascular hemodynamics, pregnant subjects, patients with a history of abdominal or thoracic surgery, and patients consuming more than 40 g of alcohol per week or taking cardiovascular drugs or other medications that might have an adverse effect on the liver were excluded from the study and control groups (Karabulut et al 2004). The procedure and purpose of the examination were explained to all subjects prior to obtaining informed consent.…”

Section: Methodsmentioning

confidence: 99%

“…Grade 3 patients had a marked increase in echogenicity with poor penetration of the posterior portion of the right lobe of the liver, and poor or no visualization of the hepatic veins and diaphragm. Each subject was asked to stop breathing during shallow inspiration to avoid modifications caused by deep inspiration, and a spectral analysis of the portal venous flow was recorded for at least 5 sec (Scatarige et al 1984;Karabulut et al 2004). The point of measurement of the portal vein was the main portal vein proximal to its bifurcation.…”

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confidence: 99%

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Portal Vein Hemodynamics in Patients with Non-Alcoholic Fatty Liver Disease

Erdoğmuş

Tamer

Büyükkaya

et al. 2008

Tohoku J. Exp. Med.

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Paralleling the rise in the incidence of obesity and diabetes worldwide, nonalcoholic fatty liver disease (NAFLD) is being increasingly recognized as one of the major causes of chronic liver disease. Doppler sonography is used as a diagnostic method in the non-invasive assessment of the hemodynamics of hepatic vascular flow in liver diseases. We investigated the effects of fatty infiltration in the liver on the Doppler flow hemodynamics of the portal vein. Doppler sonography of the liver and portal vein was performed in 60 subjects with NAFLD and 20 healthy volunteers (control). The patients were grouped into mild (grade 1), moderate (grade 2), and severe (grade 3) according to sonographic appearance of hepatosteatosis (n = 20 for each group). The vein pulsatility index (VPI), mean flow velocity (MFV), peak maximum velocity (V max ), and peak minimum velocity (V min ) of the portal vein were significantly lower in patients with NAFLD than those of the controls ( p < 0.001). The VPI was 0.20 in the patients and 0.31 in the control. The MFV was 12.3 cm/sec in the patients and 16.5 cm/sec in the control group. The portal vein flow was found to be decreased as the grade of fatty infiltration increased for VPI (r = -0.946, p < 0.001), MFV (r = -0.951, p < 0.001). The alteration in Doppler waveform pattern of portal vein with fatty liver population suggests reduced vascular compliance in the liver. doppler sonography; nonalcoholic fatty liver; portal vein pulsatility; hepatosteatosis; liver. Tohoku J. Exp. Med., 2008, 215 (1), 89-93.

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Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

Portal Vein Hemodynamics in Patients with Non-Alcoholic Fatty Liver Disease

Erdoğmuş

Tamer

Büyükkaya

et al. 2008

Tohoku J. Exp. Med.

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“…VPI is defined as a parameter that evaluates portal venous pulsatility and its major advantage is it does not depend on the angulation obtained in the Doppler sample, which makes it more reproducible. The relative lack of studies in the literature looking at VPI as a parameter in the assessment of fibrosis in patients with CHC (2,16) was the motive for this study. It is known that HCV can lead to various degrees of liver inflammation and fibrosis, with modification of the usual architecture of the liver, associated with sinusoidal vascular distortion.…”

Section: Discussionmentioning

confidence: 99%

“…The portal vein Doppler velocimetry was performed during apnea, at the beginning of inspiration to avoid changes caused by deep inspiration. Spectral analysis of the portal vein flow velocity waveform (FVW) was recorded for at least 5 seconds of suspended inspiration (16) . The measurement point for the portal vein FVW was in the extrahepatic portion, adjacent to the hepatic hilum ( Figure 1).…”

Section: Methodsmentioning

confidence: 99%

Assessment of portal venous index as a non-invasive method for diagnosing liver fibrosis in patients with chronic hepatitis C

Rocha

Diniz²,

Borges

et al. 2012

Arq. Gastroenterol.

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-Context -Hepatitis C is an important cause of chronic liver disease worldwide. The grading of hepatic fibrosis in chronic hepatitis C is important for better clinical management. However, until now, liver biopsy is the only test accepted for this purpose, despite their contraindications and complications. New methods for non-invasive assessment of hepatic fibrosis are under investigation. One proposal is the Doppler ultrasound, as a non-invasive, widely available and inexpensive. Objective -To compare Doppler parameters of portal vein in patients with chronic hepatitis C with a healthy control group and to correlate these parameters with fibrosis degree obtained by liver biopsy. Methods -Fifty patients with chronic hepatitis C submitted to liver biopsy and 44 healthy controls had Doppler of the portal vein performed, with the calculation of the portal venous index. We conducted a comparison between the averages of the two groups of portal venous index. For the correlation between portal venous index and fibrosis was employed the Spearman test. Results -There was a difference between the average portal venous index between controls (0.33 ± 0.07) and patients (0.23 ± 0.09) with P<0.001. No difference was observed between the portal venous index in patients with chronic hepatitis C who have significant fibrosis or not. The correlation between the portal venous index and fibrosis degree was reverse and moderate (r =-0.448 P<0.001). The area under the ROC curve was 78.4% (95% CI: 68.8% to 88%). The cutoff for the portal venous index was 0.28 with sensitivity of 73.5% and specificity of 71.1%. Conclusion -The portal venous index was useful in distinguishing healthy patients from patients with CHC. However, there was no significant difference in the quantification of degree of fibrosis.

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“…Some parameters allow the diagnosis of FLD with a sensibility of 83% and a specificity of 100%: a diffuse hyperechoic echotexture; increased liver echotexture compared with the kidney; and vascular blurring [5,29,37]. In addition, abnormal hepatic vein Doppler waveform patterns, specified as monophasic, biphasic, or triphasic, were reported to be indicators of fatty liver disease in adult studies [14,22].…”

Section: Introductionmentioning

confidence: 95%

Metabolic predictors for early identification of fatty liver using doppler and B-mode ultrasonography in overweight and obese adolescents

et al. 2010

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(1) to evaluate the frequency of asymptomatic fatty liver disease (FLD) using both Doppler and B-mode ultrasound (US) in overweight and obese adolescents; (2) to compare metabolic findings of fatty liver (FL) assessed by two methods; and (3) to evaluate metabolic predictors of FL shown by these methods. Fifty-nine overweight and obese adolescents aged between 9.0 and 17.0 years and 41 non-obese healthy adolescents were included in this study. B-mode and right hepatic vein Doppler ultrasonography (US) were performed and anthropometric indices, lipid profiles, and adiponectin levels were evaluated in all adolescents. HDL-C levels were significantly lower in patients with FL detected by Doppler US compared to patients without FL (p < 0.05). HDL-C levels were inversely correlated with presence of FL assessed by two methods (r = -0.285, p = 0.004; r = -0.328, p = 0.001, respectively) and adiponectin levels were correlated with presence of FL only detected by B-mode US (r = -0.263, p = 0.008). Adiponectin levels were significantly lower in patients with FL than those without FL assessed by B-Mode US (p = 0.049). Multiple regression analysis revealed that HDL-C levels was the most important predictor of FL assessed by Doppler US (p = 0.027), while body mass index was the determinant of FL assessed by two methods (p < 0.001) in asymptomatic overweight and obese adolescents. It was found that FLD, identified by both B-mode and Doppler US, is seen frequently in asymptomatic overweight and obese adolescents. Elevated BMI is associated with increased risk of FL assessed by two ultrasonographic methods. When using Doppler US, low HDL-C levels can be used as a good predictor for presence of FLD in overweight and obese adolescents.

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Doppler waveform of the hepatic veins in an obese population

Cited by 29 publications

References 16 publications

Portal Vein Hemodynamics in Patients with Non-Alcoholic Fatty Liver Disease

Portal Vein Hemodynamics in Patients with Non-Alcoholic Fatty Liver Disease

Assessment of portal venous index as a non-invasive method for diagnosing liver fibrosis in patients with chronic hepatitis C

Metabolic predictors for early identification of fatty liver using doppler and B-mode ultrasonography in overweight and obese adolescents

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