Dopamine modulation of spatial navigation memory in Parkinson's disease

Thurm, Franka; Fauser, Mareike; Doeller, Christian F.; Stankevich, Yuliya; Evens, Ricarda; Riedel, Oliver; Storch, Alexander; Lueken, Ulrike; Li, Shu-Chen

doi:10.1016/j.neurobiolaging.2015.10.019

Cited by 33 publications

(35 citation statements)

References 108 publications

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“…the very same dopamine involvement has been highlighted with special reference to modulation in hippocampal-striatal functions in PD [66]. Together, most of the cognitive impairments in PD are directly or indirectly influenced by dopaminergic homeostasis and such rationale justifiably put forwards the association between cognitive impairment and PD.…”

Section: Reviewmentioning

confidence: 96%

“…Cognitive deficient PD patients are reportedly lacking the ability to image the previously executed tasks and spatial memory functions [65,66]. Possin et al executed a study for spatial memory function and found that, PD patients are having significantly lower ability to memorize or image spatial locations or shapes than randomly selected control people [67].…”

Section: Spatial Memory Functionsmentioning

confidence: 99%

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Cognitive and Psychological Anomalies in Parkinsons Disease: An Insight into Non-Motor Characteristic Features

Choudhury¹,

Rao²,

R³

et al. 2017

Neuropsychiatry

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While most of the clinical concerns for Parkinson's disease (PD) are limited to the cardinal motor abnormalities, non-motor features like cognitive and psychological anomalies are also acquired ample of importance in last few decades. Progressive research has showcased several obvious incidences of cognitive and psychological anomalies in the pathophysiology of PD. It has been reported that, almost 30% PD sufferers show different degree of cognitive impairment but lack of awareness or negligence makes it difficult to diagnose it, at the initial stage of the disease. As a result, cognitive and psychological impairments continue to increases progressively and deteriorate the quality of life of the patient. It is presumable that, early detection of PD can be achieved by the identification of specific set of cognitive and psychological anomalies and the similar scope might open up new avenue in the non-invasive diagnosis of PD. In the present review, we have accumulated all the timely documentation on cognitive and psychological anomalies in PD and highlighted most of the non-motor features with rational justification for the relevance of their study in the early diagnosis of PD.

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Section: Reviewmentioning

confidence: 96%

Section: Spatial Memory Functionsmentioning

confidence: 99%

Cognitive and Psychological Anomalies in Parkinsons Disease: An Insight into Non-Motor Characteristic Features

Choudhury¹,

Rao²,

R³

et al. 2017

Neuropsychiatry

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“…DA medication effects on cognition in PD patients follow an inverted-U shaped and individually dosage-dependent function [17][18][19][20][21] and have been associated with improved performance in learning, visual and verbal memory, visuospatial abilities, and frontal lobe tasks [22]. In a recent study DA medication in early PD patients has been shown to have beneficial effects on spatial memory functions subserved by the hippocampal-striatal circuitry [23]. However, given that DA depletion in the striatum follows a dorsal to lateral-ventral gradient, DA medication dosages associated with improved cognitive functions supported by the dorsal striatum might also negatively affect ventral striatal functions following the "overdose" model [24,25].…”

Section: Research Yuliya Stankevichmentioning

confidence: 99%

“…In a pharmaco-behavioral crossover study we aimed to investigate the depressive symptom load in early PD patients and matched healthy controls (HC). Furthermore, we examined the association of depressive symptom load and hippocampal-striatal spatial memory [23,[30][31][32] in PD patients on versus off DA medication. Based on the findings that DA medication ameliorates depression [9,10] and cognitive performance in PD [22], specifically spatial learning and memory [23], we assumed a negative association of depressive symptom load with spatial memory performance under dopamine withdrawal (off medication).…”

Section: Research Yuliya Stankevichmentioning

confidence: 99%

“…Furthermore, we examined the association of depressive symptom load and hippocampal-striatal spatial memory [23,[30][31][32] in PD patients on versus off DA medication. Based on the findings that DA medication ameliorates depression [9,10] and cognitive performance in PD [22], specifically spatial learning and memory [23], we assumed a negative association of depressive symptom load with spatial memory performance under dopamine withdrawal (off medication). To explore the specificity of association between depressive symptom load and spatial memory on and off DA medication in early PD patients, we applied the model by Suzuki, et al [33] distinguishing three factors of depressive symptoms (dysphoria, retardation and vegetative symptoms) as assessed with the Montgomery-Asberg Depression Rating Scale [34] (MADRS).…”

Section: Research Yuliya Stankevichmentioning

confidence: 99%

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Dysphoria, dopaminergic medication and spatial memory in Parkinsons disease

Stankevich¹,

Thurm²,

Evens³

et al. 2018

Neuropsychiatry

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Depression is considered a potential risk factor for developing cognitive deficits and dementia during the progression of Parkinson's disease (PD). Depression and dysthymia are also among the most frequent neuropsychiatric comorbidities, especially in later stages of PD. Regardless of the depression diagnosis, clinical and subsyndromal depressive symptoms in PD patients are associated with decreased daily functioning. However, very little is known about subsyndromal depressive symptoms and their relations to cognitive function and dopamine medication in PD. Here we investigated depressive symptoms and spatial memory performance in 34 early PD patients compared to 36 matched healthy controls in a pharmacobehavioral cross-over study. Despite that none of the PD patients fulfilled clinical criteria for major depression or dysthymia, PD patients showed elevated scores of depressive symptoms compared to healthy controls. Depressive symptom load was further negatively correlated with spatial memory performance in PD patients when off dopaminergic medication. Furthermore, it could be shown that the factor dysphoria but not retardation or vegetative symptoms of the MADRS was associated with reduced spatial memory off dopaminergic medication. Present findings indicate that under dopaminergic withdrawal affective symptoms of depression i.e., dysphoria may be associated with spatial memory deficits in early PD patients. Future studies are needed to specify the underlying mechanisms and interactions of depressive symptoms and dopaminergic treatment in PD, especially in context of clinically relevant depression.

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Cognitive and Brain Plasticity in Old Age

Thurm¹,

2015

Encyclopedia of Geropsychology

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Dopamine modulation of spatial navigation memory in Parkinson's disease

Cited by 33 publications

References 108 publications

Cognitive and Psychological Anomalies in Parkinsons Disease: An Insight into Non-Motor Characteristic Features

Cognitive and Psychological Anomalies in Parkinsons Disease: An Insight into Non-Motor Characteristic Features

Dysphoria, dopaminergic medication and spatial memory in Parkinsons disease

Cognitive and Brain Plasticity in Old Age

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