Dopamine Loaded SiO₂ Coated Fe₃O₄ Magnetic Nanoparticles: A New Anticancer Agent in pH‐Dependent Drug Delivery

Abstract

In this present study, we have shown dopamine acts as very good agent in killing cancer cells with very high rate. We have used silica coated iron oxide magnetic particles as dopamine drug delivery agent. We have synthesized iron oxide (Fe3O4) magnetic nanoparticles (MNPs), and coated it with silicon dioxide (SiO2), then loaded it with dopamine (DA) which has been used here as anticancer drug. Here a significant improvement was found in case of drug release under acidic pH than normal blood pH. The MNPs are characterized using X‐ray diffraction (XRD), Energy Dispersive Analysis of X‐rays (EDAX), Fourier transform infrared (FTIR), Field Emission Scanning Electron Microscopy (FESEM), Transmission Electron Microscopy (TEM), High Resolution Transmission Electron Microscopy (HRTEM), Selected Area Electron Diffraction (SAED) and vibrating sample magnetometer (VSM) to confirm its structural, morphological and magnetic properties. Particles after characterization were involved in investigation of DA drug release by altering pH for better treatment of cancer. The results are very important and promising.

Anticancer, Antibacterial and Hyperthermia Studies of a Caffeine‐Based N‐Heterocyclic Carbene Silver Complex Anchored on Magnetic Nanoparticles

“…Recently, Fe 3 O 4 magnetic nanoparticles (MNPs) have emerged as intriguing class of advanced materials that possess unique features such as biocompatibility, chemical inertness, relatively less toxicity, high stability, superparamagnetism, [7] facile surface functionalization [8] and easy magnetic retrievability [9] . In this context, Fe 3 O 4 MNPs have been studied extensively for diverse biomedical applications [10] such as diagnostic imaging, drug delivery, [11] magnetic separation, [12] hyperthermia [13,14] and cancer treatment [15] . Fe 3 O 4 MNPs have received special attention in cancer treatments using magnetic hyperthermia for their great potential as mediators of heat for localized hyperthermia therapy.…”

“…[9] In this context, Fe 3 O 4 MNPs have been studied extensively for diverse biomedical applications [10] such as diagnostic imaging, drug delivery, [11] magnetic separation, [12] hyperthermia [13,14] and cancer treatment. [15] Fe 3 O 4 MNPs have received special attention in cancer treatments using magnetic hyperthermia for their great potential as mediators of heat for localized hyperthermia therapy. Magnetic hyperthermia using Fe 3 O 4 MNPs has captivated enormous attention towards alternative realm in cancer treatments as conventional methods such as chemotherapy, immunotherapy, radiation therapy and ultrasound treatments have serious drawbacks associated with side effects originating from indiscriminate killing of normal cells, insufficient temperature elevation, thermal non-homogeneity throughout the tumor and drug resistivity.…”

Difunctional Silicon Dioxide Combined with Graphene Oxide Nanocomposite to Enhance the Anticorrosion Performance of Epoxy Coatings

“…As can be seen in Figure 5 a, nitrogen adsorption/desorption results of SiO 2 are of typical type IV (based on IUPAC definition) with a hysteresis loop in the P/P 0 region of 0.45–0.95. 34 This can be ascribed to the instability of liquid N 2 in the narrow channels, indicating the presence of a mesoporous material, confirming the successful fabrication of mesoporous SiO 2 . As for BTA-SiO 2 , the hysteresis loop disappeared, which indicated that the loading of BTA and CTAB nanoparticles occupied the mesoporous material, confirming the successful loading of BTA into SiO 2 .…”

A Biocompatible, pH-Sensitive, and Magnetically Separable Superparamagnetic Hydrogel Nanocomposite as an Efficient Platform for the Removal of Cationic Dyes in Wastewater Treatment

“… 32 The bands at 1170, 1040, and 774 cm –1 are ascribed to the symmetric stretching vibration, 15 S=O stretching vibration, and C–S antisymmetric stretching modes of vinylsulfonic acid (VSA), respectively. 15 , 33 Also, the spectra of pristine SPIONs (Fe 3 O 4 nanoparticles) show the characteristic bands at 1530 and 540 cm –1 representing the −OH bending vibration mode 34 and Fe–O stretching vibration mode, respectively. 35 Furthermore, the absorption band at 1407 cm –1 in the ATR-FTIR spectrum of AA-VSA-P/SPIONs composite hydrogels shows a change in relative intensity and a slight peak shift, implying the interaction of SPIONs and carboxylate ions (COO – ) of the hydrogels.…”