No abstract

Caffeine based N‐heterocyclic carbene (NHC)‐silver complex anchored on magnetic nanoparticles (MNP‐Caff‐NHC@Ag complex) has been prepared by covalent grafting of caffeine on the surface of chloro‐functionalized Fe3O4 magnetic nanoparticles followed by complexation with silver (I) acetate. The MNP‐Caff‐NHC@Ag complex has been characterized by Fourier transform infrared (FT‐IR) spectroscopy, energy‐dispersive X‐ray (EDX) spectroscopy, transmission electron microscopy (TEM), X‐ray diffraction (XRD), thermogravimetric analysis (TGA) and vibrating sample magnetometer (VSM) analysis. The MNP‐Caff‐NHC@Ag complex displayed significant in vitro anticancer activity against human hepatocarcinoma HepG2 cell line and antibacterial activity against Escherichia coli (NCIM‐2832), Staphylococcus aureus (NCIM‐2654) and Bacillus cereus (NCIM‐2703). The hyperthermia studies revealed that MNP‐Caff‐NHC@Ag complex achieved good therapeutic temperature (47 °C) under physiological safe range of field and frequency thereby forecasting potential applications as heating mediators in magnetic hyperthermia for selectively killing of cancer cells.

No abstract

No abstract

Potentially antibreast cancer enamidines were synthesized and evaluated against human breast cancer cell line MCF7 displaying GI50values lower than doxorubicin.

Ferrocene tethered N-heterocyclic carbene-copper complex anchored on graphene ([GrFemImi]NHC@Cu complex) has been synthesized by covalent grafting of ferrocenyl ionic liquid in the matrix of graphene followed by metallation with copper (I) iodide. The [GrFemImi]NHC@Cu complex has been characterized by fourier transform infrared (FT-IR), fourier transform Raman (FT-Raman), CP-MAS 13 C NMR spectroscopy, transmission electron microscopy (TEM), thermogravimetric analysis (TGA), energy dispersive Xray (EDX) analysis, X-ray photoelectron spectroscopy (XPS), Brunauer-Emmett-Teller (BET) surface area analysis and X-ray diffractometer (XRD) analysis. This novel complex served as a robust heterogeneous catalyst for the synthesis of bioactive N-aryl sulfonamides from variety of aryl boronic acids and sulfonyl azides in ethanol by Chan-Lam coupling. Recyclability experiments were executed successfully for six consecutive runs.

Many nutraceuticals are highly potent, nontoxic, bioactive agents present in dietary vegetables, fruits and spices. They exhibit immune‐modulatory, antioxidant and anticancer activity. The major disadvantage of nutraceuticals is their low aqueous solubility and hence poor bioavailability hindering their therapeutic applications. In the present work, we herein report preparation of nanoparticles of bioactive nutraceuticals such as curcumin (1), quercetin (2), anthraquinone (3), xanthone (4), flavone (5) and vanillin (6) with a view to improve their aqueous‐phase solubility and evaluate their anticancer, antiangiogenic and antioxidant activities. The nanoparticles were prepared by controlled flow rate reprecipitation technique and characterized by spectral and microscopic techniques. Most of the nanoparticles displayed higher in‐vitro anticancer, antioxidant and in‐ovo antiangiogenic activities as compared to the corresponding bulk compounds. The biological activities of nutraceuticals are marked increased by particle size reduction to the nanoscale.

No abstract