Anticancer, Antioxidant and Antiangiogenic Activities of Nanoparticles of Bioactive Dietary Nutraceuticals

Abstract

Many nutraceuticals are highly potent, nontoxic, bioactive agents present in dietary vegetables, fruits and spices. They exhibit immune‐modulatory, antioxidant and anticancer activity. The major disadvantage of nutraceuticals is their low aqueous solubility and hence poor bioavailability hindering their therapeutic applications. In the present work, we herein report preparation of nanoparticles of bioactive nutraceuticals such as curcumin (1), quercetin (2), anthraquinone (3), xanthone (4), flavone (5) and vanillin (6) with a view to improve their aqueous‐phase solubility and evaluate their anticancer, antiangiogenic and antioxidant activities. The nanoparticles were prepared by controlled flow rate reprecipitation technique and characterized by spectral and microscopic techniques. Most of the nanoparticles displayed higher in‐vitro anticancer, antioxidant and in‐ovo antiangiogenic activities as compared to the corresponding bulk compounds. The biological activities of nutraceuticals are marked increased by particle size reduction to the nanoscale.

Anticancer, Antibacterial and Hyperthermia Studies of a Caffeine‐Based N‐Heterocyclic Carbene Silver Complex Anchored on Magnetic Nanoparticles

“…Considering aforementioned discussion and in continuation of our studies related to MNPs and biomedical applications, [22–24] we report herein in vitro anticancer, antibacterial and hyperthermia studies of a newly prepared caffeine functionalized N ‐heterocyclic carbene silver complex anchored on magnetic nanoparticles.…”

“…Undoubtedly, attempts to prepare suitably tailored NHC-metal complexes for explicitly targeting cancer cells can significantly contribute in target specific anticancer drug design and development program. [20,21] Considering aforementioned discussion and in continuation of our studies related to MNPs and biomedical applications, [22][23][24] we report herein in vitro anticancer, antibacterial and hyperthermia studies of a newly prepared caffeine functionalized N-heterocyclic carbene silver complex anchored on magnetic nanoparticles.…”

Preparation, Spectroscopic Characterization, Theoretical Investigations, and In Vitro Anticancer Activity of Cd(II), Ni(II), Zn(II), and Cu(II) Complexes of 4(3H)-Quinazolinone-Derived Schiff Base

“…These complexes can exhibit antibacterial, anticonvulsant, anti-inflammatory, hypnotic, antimalarial, and antihypertensive properties [ 8 , 9 , 10 , 11 ]. In recent years, considerable research has focused on the synthesis and properties of metal complexes of mixed ligands since they can furnish new materials with paramount applications such as electrical conductivity [ 12 ], nonlinear optical properties [ 13 ], magnetic exchange [ 14 , 15 ], photoluminescence [ 16 ], and antimicrobial activity [ 17 , 18 , 19 , 20 , 21 ]. Schiff bases as ligands with their transition metal complexes are of predominant scientific interest because of their multiple ramifications.…”

Nano-magnetite supported N-heterocyclic carbene-gold complex with pendant ferrocenyl group as a multi- modal anti-breast cancer agent

“…Considering the aforementioned and in continuation of our research associated with development of novel anti-breast cancer agents, [16,17] we herein report the multi-step synthesis of nano-magnetite supported a multi-modal anti-breast cancer agent.…”