Dopamine-assisted immobilization of partially hydrolyzed poly(2-methyl-2-oxazoline) for antifouling and biocompatible coating

Pan, Chao; Chen, Lijuan; Liu, Songtao; Zhang, Yalin; Zhang, Chong; Zhu, Haikun; Wang, Yanmei

doi:10.1007/s10853-015-9556-1

Cited by 18 publications

(8 citation statements)

References 58 publications

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“…Poly(2-oxazoline) (POX) has attracted significant attention as an alternative to PEG in biofouling applications. − Recent work elucidated its low biofouling properties and good biocompatibility, stimulating interest in POX as a valuable biomaterial and antifouling coating, , for biomedical applications . The hydropathicity of the monomer and the resulting wettability of the coatings, are believed to control the antifouling efficacy of POX.…”

Section: Introductionmentioning

confidence: 99%

“…The hydropathicity of the monomer and the resulting wettability of the coatings, are believed to control the antifouling efficacy of POX. The methyl- and ethyl-substituted analogues (MPOX and EPOX) have been shown to suppress protein adsorption, ,,, while the propyl analogue (PPOX) promotes cell adhesion and growth. , It has been proposed that this behavior is due to the increased length of the hydrophobic propyl side chain of the PPOX coating providing larger hydrophobic contact. There are several experimental studies comparing the antifouling efficacy of PEG and POX coatings. , While it is clear that both polymers show remarkable properties, such as imparting stealth abilities (avoiding immune response) for drug-delivery and protein resistance for antifouling surfaces, POX coatings generally outperform PEG coatings in most cases.…”

Section: Introductionmentioning

confidence: 99%

“…41 The hydropathicity of the monomer and the resulting wettability of the coatings, are believed to control the antifouling efficacy of POX. The methyl-and ethylsubstituted analogues (MPOX and EPOX) have been shown to suppress protein adsorption, 36,39,40,42 while the propyl analogue (PPOX) promotes cell adhesion and growth. 42,43 It has been proposed that this behavior is due to the increased length of the hydrophobic propyl side chain of the PPOX coating providing larger hydrophobic contact.…”

Section: ■ Introductionmentioning

confidence: 99%

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Hydration and Dynamics of Ligands Determine the Antifouling Capacity of Functionalized Surfaces

et al. 2019

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Biofouling is a multibillion dollar problem in the modern world, stimulating a large research effort in developing antifouling surface coatings. Existing theories that attempt to explain underlying molecular mechanisms of biofilm formation and its attenuation are not consistent with experiments and focus on different aspects of the interactions. To address this knowledge gap, we report a computational molecular dynamics study in which we assess how chemistry and surface density of commonly used antifouling surface ligands affect the interfacial properties relevant to biofouling. We compare the hydration behavior and chain dynamics of poly(ethylene glycol) (PEG) and poly(2-oxazoline) (POX) modified silica surfaces as a function of chemical composition and grafting density. We show that PEG systems exhibit greater chain dynamics, while POX systems show superior hydropathicity and hydration behavior. The observed structure–property relations for the PEG- and POX-modified surfaces provide an improved understanding of the effects of molecular features on antifouling properties and highlight the importance of ligand mobility and interfacial water structure and dynamics for antifouling efficacy. The findings can be exploited in the rational design of biofouling-resistant surfaces for industrial and biomedical applications.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

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Hydration and Dynamics of Ligands Determine the Antifouling Capacity of Functionalized Surfaces

et al. 2019

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“…et al [22,23]. Since then, a variety of dopamine-assisted grafting techniques and DOPA modified antifouling polymers have been tested to more securely attach antifouling polymers to substrate surfaces [23][24][25][26][27][28][29][30][31][32][33][34][35]. The polydopamine layer not only readily adheres to most surfaces, but also provides a surface which allows various secondary reactions to take place and could therefore more easily enable the functionalization of material surfaces [22].…”

Section: Introductionmentioning

confidence: 99%

Simple Coatings to Render Polystyrene Protein Resistant

2018

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Non-specific protein adsorption is detrimental to the performance of many biomedical devices. Polystyrene is a commonly used material in devices and thin films. Simple reliable surface modification of polystyrene to render it protein resistant is desired in particular for device fabrication and orthogonal functionalisation schemes. This report details modifications carried out on a polystyrene surface to prevent protein adsorption. The trialed surfaces included Pluronic F127 and PLL-g-PEG, adsorbed on polystyrene, using a polydopamine-assisted approach. Quartz crystal microbalance with dissipation (QCM-D) results showed only short-term anti-fouling success of the polystyrene surface modified with F127, and the subsequent failure of the polydopamine intermediary layer in improving its stability. In stark contrast, QCM-D analysis proved the success of the polydopamine assisted PLL-g-PEG coating in preventing bovine serum albumin adsorption. This modified surface is equally as protein-rejecting after 24 h in buffer, and thus a promising simple coating for long term protein rejection of polystyrene.

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“…hydrophilicity and biocompatibility) to PEG and less degradation than PEG. [25][26][27][28][29] Cavallaro and coworkers reported that the films developed via plasma deposition of 2-methyl-2-oxazoline (MOXA) could resist the adsorption of Staphylococcus epidermidis and cells by more than 90% regardless of the type of substrate used. 30 Bai and coworkers developed poly(2-methyl-2-oxazoline-random-glycidyl methacrylate) (PMOXA-r-GMA) comb copolymers.…”

Section: Introductionmentioning

confidence: 99%

A binary mixed polymer brush coating with adjusted hydrophobic property to control protein adsorption

Chen

Atif

et al. 2021

Mater. Adv.

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Dopamine-assisted immobilization of partially hydrolyzed poly(2-methyl-2-oxazoline) for antifouling and biocompatible coating

Cited by 18 publications

References 58 publications

Hydration and Dynamics of Ligands Determine the Antifouling Capacity of Functionalized Surfaces

Hydration and Dynamics of Ligands Determine the Antifouling Capacity of Functionalized Surfaces

Simple Coatings to Render Polystyrene Protein Resistant

A binary mixed polymer brush coating with adjusted hydrophobic property to control protein adsorption

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