A binary mixed polymer brush coating with adjusted hydrophobic property to control protein adsorption

Chen, Chao-Shi; Atif, Muhammad; He, Kang; Zhang, Miao; Chen, Lijuan; Wang, Yanmei

doi:10.1039/d0ma00932f

Cited by 7 publications

(6 citation statements)

References 53 publications

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“…Advanced applications for temperature-controlled protein adsorption can be divided into two subcategories: temperature-controlled protein fouling/non-fouling or protein separation [ 22 , 23 , 24 ] and temperature-controlled protein orientation [ 25 ]. Controlling the interaction between surfaces and proteins in an aqueous environment is important for the prediction of the protein adsorption during the first step of surface fouling.…”

Section: Introductionmentioning

confidence: 99%

Temperature-Responsive Polymer Brush Coatings for Advanced Biomedical Applications

et al. 2022

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Modern biomedical technologies predict the application of materials and devices that not only can comply effectively with specific requirements, but also enable remote control of their functions. One of the most prospective materials for these advanced biomedical applications are materials based on temperature-responsive polymer brush coatings (TRPBCs). In this review, methods for the fabrication and characterization of TRPBCs are summarized, and possibilities for their application, as well as the advantages and disadvantages of the TRPBCs, are presented in detail. Special attention is paid to the mechanisms of thermo-responsibility of the TRPBCs. Applications of TRPBCs for temperature-switchable bacteria killing, temperature-controlled protein adsorption, cell culture, and temperature-controlled adhesion/detachment of cells and tissues are considered. The specific criteria required for the desired biomedical applications of TRPBCs are presented and discussed.

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Section: Introductionmentioning

confidence: 99%

Temperature-Responsive Polymer Brush Coatings for Advanced Biomedical Applications

et al. 2022

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“…Since identical conditions were employed for the grafting reactions of all block copolymers, the method could potentially be used to synthesize binary brushes. Such coatings have become of increasing interest as they commonly exhibit switchable surface properties that can be applied in responsive coatings. ,,,− The ability to easily synthesize such mixed polymer systems on any substrate would greatly enhance the applicability of responsive coatings.…”

Section: Resultsmentioning

confidence: 99%

“…The produced coatings were analyzed using spectroscopic ellipsometry, static water contact angle (SWCA) measurements, and X-ray photoelectron spectroscopy (XPS). The procedure was finally employed to simultaneously graft two different block copolymers to one substrate to achieve binary brushes, which expands the applicability of our approach for facile preparation of advanced polymer coatings even further. ,, …”

Section: Introductionmentioning

confidence: 94%

“…The procedure was finally employed to simultaneously graft two different block copolymers to one substrate to achieve binary brushes, which expands the applicability of our approach for facile preparation of advanced polymer coatings even further. 39,40,53 ■ EXPERIMENTAL SECTION Materials. All chemical reagents were used without further purification unless otherwise specified.…”

Section: ■ Introductionmentioning

confidence: 99%

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Modular and Substrate-Independent Grafting-To Procedure for Functional Polymer Coatings

2023

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The ability to tailor polymer brush coatings to the last nanometer has arguably placed them among the most powerful surface modification techniques currently available. Generally, the synthesis procedures for polymer brushes are designed for a specific surface type and monomer functionality and cannot be easily employed otherwise. Herein, we describe a modular and straightforward two-step grafting-to approach that allows introduction of polymer brushes of a desired functionality onto a large range of chemically different substrates. To illustrate the modularity of the procedure, gold, silicon oxide (SiO2), and polyester-coated glass substrates were modified with five different block copolymers. In short, the substrates were first modified with a universally applicable poly(dopamine) primer layer. Subsequently, a grafting-to reaction was performed on the poly(dopamine) films using five distinct block copolymers, all of which contained a short poly(glycidyl methacrylate) segment and longer segment of varying chemical functionality. Ellipsometry, X-ray photoelectron spectroscopy, and static water contact angle measurements confirmed successful grafting of all five block copolymers to the poly(dopamine)-modified gold, SiO2, and polyester-coated glass substrates. In addition, our method was used to provide direct access to binary brush coatings, by simultaneous grafting of two different polymer materials. The ability to synthesize binary brush coatings further adds to the versatility of our approach and paves the way toward production of novel multifunctional and responsive polymer coatings.

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“…27 Similarly, several random and block polymers of GMA with other suitable comonomers have been used to create stimuli-responsive surfaces for regulation of protein adsorption. 28,29 Alkyne−azide click reactions are quick, quantitative, selective, and robust; 30 they exhibit very high functional group tolerance and therefore have been extensively used for developing versatile strategies for polymer synthesis and their modification in solution, 31 as well as in polymer coatings. 32 To create surfaces amenable to click chemistry, it is necessary to install one of the participating functional groups on the surface.…”

Section: ■ Introductionmentioning

confidence: 99%

Itaconate-Based Clickable Surface-Anchored Cross-Linked Polymeric Coatings

Damodara,

Ramakrishnan

2023

Macromolecules

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Reactive coatings are those that permit installation of desired segments in a postcoating step; several approaches have been developed to design polymers that can covalently anchor to the substrate while at the same time providing a handle for further functionalization. Here, we present a simple approach to prepare surface-anchored coatings that can be functionalized with desired segments in a postcoating step; to achieve this, we prepared a heterodiester of itaconic acid (IA), namely, 2-hydroxyethyl, propargyl itaconate (HEPI), which upon free-radical-initiated polymerization yielded a polymer, PHEPI. This polymer is endowed with three attractive features: (i) the pendant hydroxyl groups can react with Si−OH groups on suitably treated glass/silicon surfaces; (ii) the pendant propargyl groups can help install chosen segments onto the coating, via azide−alkyne reaction, to render the desired properties to the surface, and (iii) thermally induced cross-linking of the coating that occurs at ∼140 °C, which helps create robust surface-anchored coatings of desired thickness. Derivatization of PHEPI coatings was easily done by treatment with a variety of organic azides, such as PEG-azide, cetyl azide, fluoroalkyl azide, etc., to yield surfaces with distinct characteristics; the derivatized surfaces were characterized by contact angle measurements, infrared, and X-ray photoelectron spectroscopy. Further, we demonstrate that this polymer can also be spray-coated onto paper, and thus it serves as a reactive primer for covalently modifying their surface properties at a late stage. In addition, we also show that the propargyl groups in Si-coated PHEPI can be clicked using a photoinitiated thiol-yne reaction, which in turn permitted the photopatterning of coated substrates. In summary, this simple approach, starting from readily available and biosourced IA, provides ample scope for further elaboration to generate designer surfaces that could form the basis for a range of potential applications.

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A binary mixed polymer brush coating with adjusted hydrophobic property to control protein adsorption

Cited by 7 publications

References 53 publications

Temperature-Responsive Polymer Brush Coatings for Advanced Biomedical Applications

Temperature-Responsive Polymer Brush Coatings for Advanced Biomedical Applications

Modular and Substrate-Independent Grafting-To Procedure for Functional Polymer Coatings

Itaconate-Based Clickable Surface-Anchored Cross-Linked Polymeric Coatings

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