Donor quality of life in living-donor lobar lung transplantation

Nishioka, Mai; Yokoyama, Chie; Iwasaki, M.; Inukai, Michiko; Sunami, Naomi; Oto, Takahiro

doi:10.1016/j.healun.2011.07.004

Cited by 10 publications

(17 citation statements)

References 15 publications

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“…While there is a low incidence of medical complications in donors in LDLLT, clinicians should pay more attention to their HRQOL during follow‐up . We found only two studies on postoperative HRQOL, but both studies presented a cross‐sectional design assessing HRQOL of LDLLT donors only after donation . The present study offers two advantages over these previous studies.…”

Section: Discussionmentioning

confidence: 89%

“…First, by prospectively examining both preoperative and postoperative measurements, we could directly analyze the impacts of donation. In the previous postoperative cross‐sectional analysis , it was not only impossible to compare their data with preoperative states, but patient demographics and a wide time range since donation (1–78 months and 18–72 months ) may have affected the results. Second, we measured multiple outcomes, which enabled us to assess the impacts of donation from multiple dimensions.…”

Section: Discussionmentioning

confidence: 99%

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A Prospective Study Analyzing One-Year Multidimensional Outcomes in Living Lung Transplant Donors

Chen

Oga

Sakai

et al. 2013

American Journal of Transplantation

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The success of living‐donor lobar lung transplantation (LDLLT) largely depends on donor outcome; but to date, no authors have studied health‐related quality of life (HRQOL) of donors. We prospectively evaluated multidimensional outcomes before and 1 year after donor lobectomies. Patient‐reported HRQOL, dyspnea, psychological status and sleep quality, and physiological pulmonary function were determined. All donors were alive without any limitations in their activities of daily living after 1 year. Postoperative pulmonary function was better than the estimated preoperative values; but, with respect to HRQOL, four of the eight subscales of the Medical Outcomes Study 36‐item short form (SF‐36) deteriorated significantly after donation. In addition, dyspnea assessed by the modified Medical Research Council scale also worsened significantly. In contrast, postoperative anxiety assessed by the Hospital Anxiety and Depression Scale significantly improved from baseline. The donors whose recipients died reported lower SF‐36 scores with worsening sleep quality measured by Pittsburgh Sleep Quality Index. Thus, although postoperative pulmonary functions in donors were preserved, their HRQOL and dyspnea deteriorated postoperatively. Moreover, HRQOL and sleep quality were impaired in recipients who experienced poor outcomes. To capture the comprehensive outcomes in LDLLT donors after donation, patient‐reported outcomes should be analyzed separately from physiological outcomes.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

A Prospective Study Analyzing One-Year Multidimensional Outcomes in Living Lung Transplant Donors

Chen

Oga

Sakai

et al. 2013

American Journal of Transplantation

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“…Each patient completed a series of questionnaires including the SF 36 (37), SGRQ (38,39), and hospital anxiety and depression score questionnaire (40). In addition, questions focusing on device use (e.g., wheelchair or rollator) were included.…”

Section: Assessment Of Health-related Quality Of Lifementioning

confidence: 99%

Low Exercise Tolerance Correlates With Reduced Inspiratory Capacity and Respiratory Muscle Function in Recipients With Advanced Chronic Lung Allograft Dysfunction

et al. 2013

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“…Since each live lung recipient typically has two donors, the overall donation/transplant scenario puts three people at risk for death and morbidity, while only one of the three (i.e., the recipient) has a likelihood of medically benefitting from the procedure. Relationships between donors, recipient, and non-donors may profoundly affect psychosocial outcomes of all involved (13, 14), and live lung donor and recipient outcomes may further complicate matters.…”

Section: Introductionmentioning

confidence: 99%

Morbidity and Mortality of Live Lung Donation: Results From the RELIVE Study

Yusen

Hong

Messersmith

et al. 2014

American Journal of Transplantation

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The Renal and Lung Living Donors Evaluation Study (RELIVE) assesses outcomes of live lung (lobectomy) donors. This is a retrospective cohort study at University of Southern California (USC) and Washington University (WASHU) Medical Centers (1993–2006), using medical records to assess morbidity and national databases to ascertain post-donation survival and lung transplantation. Serious complications were those requiring significant treatment, potentially life-threatening, or leading to prolonged hospitalization. The 369 live lung donors (287 USC, 82 WASHU) were predominantly white, non-Hispanic, and male; 72% had a biological relationship to the recipient, and 30% were recipient parents. Serious complications occurred in 18% of donors; 2.2% underwent reoperation, and 6.5% had an early rehospitalization. The two centers had significantly different incidences of serious complications (p<0.001). No deaths occurred and no donors underwent lung transplantation during 4,000+ person-years of follow-up (death: minimum 4, maximum 17 years; transplant: minimum 5, maximum 19). Live lung donation remains a potential option for recipients when using deceased donor lungs lacks feasibility. However, the use of two live donors for each recipient and the risk of morbidity associated with live lung donation do not justify this approach when deceased lung donors remain available. Center effects and long-term outcomes require further evaluation.

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Donor quality of life in living-donor lobar lung transplantation

Cited by 10 publications

References 15 publications

A Prospective Study Analyzing One-Year Multidimensional Outcomes in Living Lung Transplant Donors

A Prospective Study Analyzing One-Year Multidimensional Outcomes in Living Lung Transplant Donors

Low Exercise Tolerance Correlates With Reduced Inspiratory Capacity and Respiratory Muscle Function in Recipients With Advanced Chronic Lung Allograft Dysfunction

Morbidity and Mortality of Live Lung Donation: Results From the RELIVE Study

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