A Prospective Study Analyzing One-Year Multidimensional Outcomes in Living Lung Transplant Donors

Abstract

The success of living‐donor lobar lung transplantation (LDLLT) largely depends on donor outcome; but to date, no authors have studied health‐related quality of life (HRQOL) of donors. We prospectively evaluated multidimensional outcomes before and 1 year after donor lobectomies. Patient‐reported HRQOL, dyspnea, psychological status and sleep quality, and physiological pulmonary function were determined. All donors were alive without any limitations in their activities of daily living after 1 year. Postoperative pulmonary function was better than the estimated preoperative values; but, with respect to HRQOL, four of the eight subscales of the Medical Outcomes Study 36‐item short form (SF‐36) deteriorated significantly after donation. In addition, dyspnea assessed by the modified Medical Research Council scale also worsened significantly. In contrast, postoperative anxiety assessed by the Hospital Anxiety and Depression Scale significantly improved from baseline. The donors whose recipients died reported lower SF‐36 scores with worsening sleep quality measured by Pittsburgh Sleep Quality Index. Thus, although postoperative pulmonary functions in donors were preserved, their HRQOL and dyspnea deteriorated postoperatively. Moreover, HRQOL and sleep quality were impaired in recipients who experienced poor outcomes. To capture the comprehensive outcomes in LDLLT donors after donation, patient‐reported outcomes should be analyzed separately from physiological outcomes.

Living Related Lung Transplantation

“…Post-operative complications before discharge were seen in 20%. We also reported that health related quality of life and dyspnea of the living-donors deteriorated postoperatively in a prospective study (32).…”

Postoperative pulmonary function and complications in living-donor lobectomy

“…Nevertheless, all previously reported studies were based on data from Z 10 years ago, whereas our study included the most recent data. In addition, multidimensional analysis is important in evaluating the outcomes of donor lobectomies 19 ; however, quality of life investigations were not performed in this study because not all donors in the study period were included in the study of the quality of life.…”

Inverted Lobes Have Satisfactory Functions Compared With Noninverted Lobes in Lung Transplantation

“…This study was a nonrandomized retrospective study performed at a single institution, and a relatively small number of transplant procedures were evaluated. In terms of the evaluation of donor outcomes, because the living donors were healthy persons, multidimensional evaluations of the outcomes are required [20].…”