Domperidone Administration to Increase Breast Milk Production in Lactating Mothers of Premature Newborns: A Randomized, Double-Blind Placebo Controlled Trial

Silva, O P da; Knoppert, David; Forret, Penelope A.; Angelini, Michelle

doi:10.1203/00006450-199904020-01662

Cited by 64 publications

(178 citation statements)

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“…A small controlled study in the use of domperidone on mothers with preterm infants having insufficient milk showed increased milk quantity in two-third mothers, but the sample size was too small for routine recommendation. 16 …”

Section: Discussionmentioning

confidence: 99%

Initiation of relactation: an Army Hospital based study of 381 cases

Tomar

2016

Int J Contemp Pediatr

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Section: Discussionmentioning

confidence: 99%

Initiation of relactation: an Army Hospital based study of 381 cases

Tomar

2016

Int J Contemp Pediatr

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“…18 -21 Several studies that do evaluate the effects of medications on lactation were undertaken in puerperal women who were experiencing lactation difficulties. [22][23][24] The recommendations that these drugs be used in adoptive mothers presupposes that they will have similar effects in nonpregnant women.…”

Section: Supporting Evidencementioning

confidence: 99%

Nursing the Adopted Infant

Bryant¹

2006

The Journal of the American Board of Family Medicine

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Background: Breastfeeding is commonly accepted as the preferred method of infant nutrition for various reasons, both nutritional and emotional. For some who have become parents by adoption, there is a strong desire to induce lactation for adoptive nursing.Methods: Information regarding adoptive nursing was initially obtained for the author's personal experience from searching the internet and speaking with other adoptive mothers. The medical literature was also searched through OVID/MEDLINE using pertinent terms, including induced lactation, adoptive nursing, domperidone, and metoclopramide. Both the American Academy of Family Physicians and the American Academy of Pediatrics have policy statements on breastfeeding that include assisting or encouraging adoptive mothers to induce lactation for adoptive nursing.1,2 That said, there is very little in the medical literature on how to help an adoptive mother in her endeavor to induce lactation. Probably, most physicians and adoptive parents are unaware of this potential opportunity. Many adoptive parents have little notice of placement dates or are adopting older infants who are less likely to want to nurse.Although undoubtedly a small trend, many women are attempting to nurse their adopted babies. Much of what information is available comes from various Internet sources and a few publications. Parents are able to access lactation protocols on the Internet and from other laypersons via Internet groups. These protocols involve using various methods from simply performing nipple stimulation to using multiple medicines and herbs to mimic the physiology necessary to produce milk. MethodsFor this article, the medical literature was reviewed in search of evidence to support currently popular recommendations for inducing lactation. The terms adoptive nursing, induced lactation, metoclopramide, domperidone, galactogogue, fenugreek, and blessed thistle were searched in the databases OVID/ MEDLINE, Micromedex, and Natural Medicines Comprehensive Database. Searches were limited to English language articles. Articles that had to do with medication effects on lactation, placebo-controlled trials or drug-drug comparisons, and reviews of induced lactation cases were reviewed. Articles that were referenced frequently by other sources were also reviewed. Also because of the attention given to domperidone by the US Food and Drug Administration (FDA), specific articles were searched using domperidone or metoclopramide and arrhythmia. There were no large studies and no randomized controlled trials. Most of the objective data were obtained from women already lactating.

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“…Em caso de aparecimento de sintomas depressivos, a terapêutica deve ser descontinuada 65 . A dompe-ridona, que é uma droga pró-cinética, também aumenta a produção láctea, sendo detectada em pequenas concentrações no leite materno 69 ; no entanto, documento recente da Agência Americana de Controle de Medicamentos e Alimentos (U.S. Food and Drug Administration -FDA) advertiu contra seu uso na lactação 70 .…”

Section: Ordenha Mamáriaunclassified

Breastfeeding in premature infants: in-hospital clinical management

Nascimento¹,

Issler²

2004

J Pediatr (Rio J)

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Como citar este artigo: do Nascimento MBR, Issler H. Aleitamento materno em prematuros: manejo clínico hospitalar. J Pediatr (Rio J). 2004;80(5 Supl):S163-S172. AbstractObjective: To describe the importance of breastfeeding and its promotion in the in-hospital clinical management of premature newborns. Source of data:The authors made an extensive literature review on the topic, including technical books, theses, publications of national and international organizations, and search on MEDLINE database (1990 to 2003), using the following key words and boolean operators: breastfeeding AND low birth weight and breastfeeding AND preterm infant. Some significant references cited in the reviewed publications were used as well.Summary of the findings: After this review we conclude that many aspects make the breast milk particularly suitable to the premature newborn feeding. Despite being highly desirable, little success in breastfeeding preterm infants is generally observed, particularly in special care neonatal units, although there are evidences suggesting that a highly supportive hospital environment can make it possible to breastfeed these infants.Conclusions: Although breastfeeding premature infants represents a challenge, it is feasible if appropriate help and support are provided. Mothers of premature infants need information and support to make informed decisions about their infants feeding.J Pediatr (Rio J). 2004;80(5 Supl):S163-S172: Breastfeeding, human milk, newborn, preterm infant, neonatal care. ResumoObjetivo: Abordar a importância do aleitamento materno e sua promoção no manejo clínico-hospitalar de recém-nascidos pré-termo.Fonte dos dados: Foi realizada extensa revisão bibliográfica sobre o tópico, sendo selecionado material oriundo de livros-texto, teses, publicações de organismos nacionais e internacionais e artigos publicados selecionados a partir de pesquisa na base de dados MEDLINE referente ao período de 1990 a 2003, utilizando as palavras-chave breastfeeding and low birth weight e breastfeeding and preterm infant. Algumas referências relevantes dos trabalhos selecionados também foram utilizadas. Síntese dos dados:A partir da literatura levantada, verifica-se que vários aspectos tornam o leite materno particularmente adequado para a alimentação do recém-nascido prematuro. No entanto, observase, de modo geral, uma baixa incidência de êxito na amamentação de prematuros, especialmente em unidades neonatais de risco, apesar de haver evidências de que uma postura hospitalar favorável possibilite o aleitamento nessas crianças.Conclusões: Amamentar prematuros ainda é um desafio, mas é factível desde que haja apoio e suporte apropriados, principalmente pelos profissionais de saúde. As mães de prematuros necessitam de mais informações sobre a importância da amamentação para que possam tomar decisões sobre a nutrição dos seus filhos. ARTIGO DE REVISÃOO aleitamento materno (AM) é o modo mais natural e seguro de alimentação para a criança pequena, devendo ser exclusivo até os 6 meses. A partir dessa idade, de...

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Domperidone Administration to Increase Breast Milk Production in Lactating Mothers of Premature Newborns: A Randomized, Double-Blind Placebo Controlled Trial

Cited by 64 publications

References 0 publications

Initiation of relactation: an Army Hospital based study of 381 cases

Initiation of relactation: an Army Hospital based study of 381 cases

Nursing the Adopted Infant

Breastfeeding in premature infants: in-hospital clinical management

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