Does Topical Ozone Therapy Improve Patient Comfort After Surgical Removal of Impacted Mandibular Third Molar? A Randomized Controlled Trial

Sivalingam, Varun P.; Panneerselvam, Elavenil; Raja, Krishnakumar; Gopi, Gayathri

doi:10.1016/j.joms.2016.09.014

Cited by 35 publications

(43 citation statements)

References 21 publications

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“…Previous studies used ozone therapy through gel applied in the extra oral region immediately after removal of lower third molars, 1, 3, 5 and 7 postoperative days did not show the efficacy of ozone in reducing edema and trismus [5]. Ozonized gel applied to the surgical wound for 2 min, twice daily for 3 days, decreased operative pain, oedema and trismus [17]. Ozonized gel, contains stable ozonide which, when in contact with the wound (body temperature), decomposes to reactive active ozone in a prolonged way [21].…”

Section: Discussionmentioning

confidence: 86%

“…The inclusion criteria were as follows: (1) age between 18 and 30 years; (2) good general health; (3) the presence of bilateral mandibular third molar with class II position, type B impaction according to Pell-Gregory [6]. The exclusion criteria were: (1) any systemic condition which might contraindicate the ozone therapy; (2) status of pregnancy or lactation; (3) acute hemorrhage during the last 30 days; (4) pericoronitis or signs of infection/inflammation; and (5) smoking habit [17].…”

Section: Eligibility Criteriamentioning

confidence: 99%

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Influence of ozonized water on pain, oedema, and trismus during impacted third molar surgery: a randomized, triple blind clinical trial

et al. 2020

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Background: This study aimed to evaluate the efficacy of ozonized water on pain, oedema and trismus after impacted third molar mandibular surgeries when compared to double distilled water. A randomized triple blind trial was conducted. Methods: Patients with third molars class II-B of Pell-Gregory were included, and surgical extraction was performed. Irrigation was done with ozonized (group 1) or double distilled water (group 2). The type of irrigation and the side to be operated were randomized. Neither the patients nor the operator or evaluator were aware of the irrigation solution. Pain, oedema and trismus were evaluated at baseline, 24-h, 48-h, 72-h and 7-days after treatment. The data were evaluated by Friedman, Wilcoxon, Mann-Whitney tests, and size effect. Results: It was included 8 men and 12 women, with a mean age of 20.9y.o. The initial pain mean was 7.94 (±12.81) (group 1) and 5.50 (±9.12) (group 2) (p > 0,05). There was a statistically significant reduction of pain, oedema and trismus in intragroup analysis (p < 0.05). There was no statistically significant difference (p > 0.05) when comparing the oedema and trismus between groups. The size effect ranged from small (0.23) to large (1.29). Conclusions: It was concluded that ozonized water was compatible as irrigation method, not inferior to double distilled water, and had satisfactory effects on management of pain, oedema and trismus after surgical removal of the third molar. Trial registration: This clinical trial was registered in ClinicalTrials.gov NCT03501225 on April 18, 2018.

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Section: Discussionmentioning

confidence: 86%

Section: Eligibility Criteriamentioning

confidence: 99%

Influence of ozonized water on pain, oedema, and trismus during impacted third molar surgery: a randomized, triple blind clinical trial

et al. 2020

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“…Sivalingam ve ark. da üçüncü molar cerrahisinden sonra ozonun ağrı dindirici etkisini bildirdi 40 . Ozonun bu etkisi aftöz stomatit gibi şiddetli ağrılı lezyonlarda da belirgin bulundu 22. Bu çalışmanın sınırları içerisinde, ozon tedavisinin gingivektomi ve gingivoplasti cerrahileri sonrası yara iyileşmesini geliştirdiği ve 3.…”

Section: Discussionunclassified

The effects of ozone therapy on wound healing after gingivectomy operations: a controlled clinical study

Taşdemir¹,

Köy²,

Oskaybaş³

et al. 2019

EÜ Dişhek Fak Derg

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“…The topical route is the main route used for wounds and ulcers, such as those occurring in the diabetic foot (Izadi et al, 2019;Martínez-Sánchez et al, 2005) and also in cases of burns (Campanati et al, 2013). Also, the use of topical ozone therapy was widely used in dental procedures (Sivalingam et al, 2017). The primary vehicles for topical uses are water, saline, or oil and the ozonation of these vehicles can occur before or during the procedure, the area to be treated can be submerged in the ozonated vehicle or spread/applied directly over the area (Campanati et al, 2013;Izadi et al, 2019).…”

Section: Route Of Administrationmentioning

confidence: 99%

Clinical Uses and Molecular Aspects of Ozone Therapy: A Review

Pivotto¹,

Banhuk²,

Staffen³

et al. 2020

OnLine Journal of Biological Sciences

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Ozone was discovered over a hundred years ago and since then, it has been widely used in many areas, with the primary use as a disinfectant in various ways, but with applications in diverse conditions. More recently, the use of ozone has extended to other fronts, using it to treat different pathologies. Extensive studies have shown its effects, as well as the safety of its application in various modalities of use. Other studies showed its toxicity, which depends on the doses of use. Emerging evidence revealed that ozone also plays an important role in the wound healing and modulation of immune cells, describing the molecular pathways responsible for these actions and describing therapeutic actions in the treatment of wounds, pain, postoperative and infectious diseases. Ozone use has already been documented in different doses, forms of use and routes of application, depending on the clinical situation and an adaptation is necessary for a better result. Thus, this review summarizes the main clinical uses of ozone, presenting the molecular pathways responsible for its actions, as well as discussing the main routes of use, doses and, vehicles used in the clinic.

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Does Topical Ozone Therapy Improve Patient Comfort After Surgical Removal of Impacted Mandibular Third Molar? A Randomized Controlled Trial

Cited by 35 publications

References 21 publications

Influence of ozonized water on pain, oedema, and trismus during impacted third molar surgery: a randomized, triple blind clinical trial

Influence of ozonized water on pain, oedema, and trismus during impacted third molar surgery: a randomized, triple blind clinical trial

The effects of ozone therapy on wound healing after gingivectomy operations: a controlled clinical study

Clinical Uses and Molecular Aspects of Ozone Therapy: A Review

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