Influence of ozonized water on pain, oedema, and trismus during impacted third molar surgery: a randomized, triple blind clinical trial

Abstract

Background: This study aimed to evaluate the efficacy of ozonized water on pain, oedema and trismus after impacted third molar mandibular surgeries when compared to double distilled water. A randomized triple blind trial was conducted. Methods: Patients with third molars class II-B of Pell-Gregory were included, and surgical extraction was performed. Irrigation was done with ozonized (group 1) or double distilled water (group 2). The type of irrigation and the side to be operated were randomized. Neither the patients nor the operator or evaluator were aware of the irrigation solution. Pain, oedema and trismus were evaluated at baseline, 24-h, 48-h, 72-h and 7-days after treatment. The data were evaluated by Friedman, Wilcoxon, Mann-Whitney tests, and size effect. Results: It was included 8 men and 12 women, with a mean age of 20.9y.o. The initial pain mean was 7.94 (±12.81) (group 1) and 5.50 (±9.12) (group 2) (p > 0,05). There was a statistically significant reduction of pain, oedema and trismus in intragroup analysis (p < 0.05). There was no statistically significant difference (p > 0.05) when comparing the oedema and trismus between groups. The size effect ranged from small (0.23) to large (1.29). Conclusions: It was concluded that ozonized water was compatible as irrigation method, not inferior to double distilled water, and had satisfactory effects on management of pain, oedema and trismus after surgical removal of the third molar. Trial registration: This clinical trial was registered in ClinicalTrials.gov NCT03501225 on April 18, 2018.

The Effect of Ozone Gel on Bone Regeneration Following Enucleation of Maxillary Cysts

“…Although some studies (37,38) proved effectiveness of local application of ozone in increasing patient comfort and decreasing post-operative sequalae after surgical impaction therapy, rare clinical studies in literature conducted on patients to assess effect of ozone on bone regeneration after oral surgical procedures.…”

Ozone Gel in Chronic Periodontal Disease: A Randomized Clinical Trial on the Anti-Inflammatory Effects of Ozone Application

“…In the last few years, a renewed interest in the therapeutic potential of ozone has emerged. In particular, the focus is on the ability to promote wound healing, to attenuate the adverse effects of inflammation by reducing the oxidative activities of inflammatory cells, to express antimicrobial activities against various bacterial species and mycetes pathogenic for humans, and also against biofilm-producing and antibiotic-resistant bacteria, thus offering chances of overcoming antibiotic-resistance issues [30][31][32][33][34][35][36][37][38][39] (Figure 2).…”

Efecto antimicrobiano de la irrigación postquirúrgica con agua ozonificada en el alveolo durante exodoncias simples

“…Por otra parte, en un estudio (Ahmedi et al, 2016) llevado sobre 20 pacientes donde se evaluó la eficacia del agua ozonizada sobre el dolor, el edema y el trismo en comparación con el agua bidestilada después de cirugías mandibulares, se demostró que el agua ozonizada era compatible como método de irrigación, no inferior al agua bidestilada, y tenía efectos satisfactorios en el manejo del dolor, edema y trismo después de la exodoncia quirúrgica del tercer molar (Glória et al, 2020). Así mismo, (Kazancioglu et al, 2014) mostraron resultados comprometedores, los efectos de la ozonoterapia en el dolor, hinchazón y trismo después de la cirugía del tercer molar después de la aplicación del ozono no mostró beneficios con respecto a la hinchazón postoperatoria sin embargo fue relativamente útil para la disminución del dolor postoperatorio mediante la escala analógica visual (EAV) y calidad de vida.…”