Does the setup of Monte Carlo simulations influence the calculated properties and effect of gold nanoparticles in radiation therapy?

Spirou, Spiridon V.; Makris, D.; Loudos, George

doi:10.1016/j.ejmp.2015.05.008

Cited by 7 publications

(4 citation statements)

References 16 publications

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“…Tran et al showed that whatever the proton energy, the dose enhancement is about ten from 100 to 1000 nm from the NP for energies under 10 MeV, this value increasing with the radial distance up to 1 µm and then becoming nearly constant . More precisely a dose enhancement over several µm in the depth direction and several tens of nm in the radial direction is predicted (Kwon et al, 2014;Spirou et al, 2015). In addition, metallic NP interaction with proton beams are known to generate particle-induced X-(or gamma-) ray emission i.e.…”

Section: Is There An Energy Dependency?mentioning

confidence: 99%

Actual questions raised by nanoparticle radiosensitization

Brun

Sicard-Roselli

2016

Radiation Physics and Chemistry

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Section: Is There An Energy Dependency?mentioning

confidence: 99%

Actual questions raised by nanoparticle radiosensitization

Brun

Sicard-Roselli

2016

Radiation Physics and Chemistry

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“…However, the results are still controversial regarding the involved and prominent interaction processes of ionizing radiation with the GNPs, which have effects on dose enhancement factor (DEF) in tumor. Until now, the most effective parameters have been investigated such as the dimension of nanoparticles, high molar concentrations, and the lower energies of the photons or gamma rays to obtain the higher doses by experimental dosimetry and MC methods [3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19]. …”

Section: Purposementioning

confidence: 99%

Investigation of the gold nanoparticles effects on the prostate dose distribution in brachytherapy: gel dosimetry and Monte Carlo method

Khosravi¹,

Hashemi²,

Rahmani³

et al. 2016

jcb

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PurposeIn this work, gold nanoparticles (GNPs) were embedded in the MAGIC-f polymer gel irradiated with the 192Ir brachytherapy sources.Material and methodsAt the first plexiglas phantom was made as the human pelvis. The GNPs were synthesized with 15 nm in diameter and 0.1 mM (0.0197 mg/ml) in concentration by using a chemical reduction method. Then, the MAGIC-f gel was synthesized. The fabricated gel was poured into the tubes located at the prostate (with and without the GNPs) locations of the phantom. The phantom was irradiated with 192Ir brachytherapy sources for prostate cancer. After 24 hours, the irradiated gels was read by using Siemens 1.5 Tesla MRI scanner. Following the brachytherapy practices, the absolute doses at the reference points and isodose curves were extracted and compared by experimental measurements and Monte Carlo (MC) simulations.ResultsThe mean absorbed doses in the presence of the GNPs in prostate were 14% higher than the corresponding values without the GNPs in the brachytherapy. The gamma index analysis (between gel and MC) using 7%/7 mm was also applied to the data and a high pass rate achieved (91.7% and 86.4% for analysis with/without GNPs, respectively).ConclusionsThe real three-dimensional analysis shows the comparison of the dose-volume histograms measured for planning volumes and the expected one from the MC calculation. The results indicate that the polymer gel dosimetry method, which developed and used in this study, could be recommended as a reliable method for investigating the dose enhancement factor of GNPs in brachytherapy.

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“…The macro language makes GATE easier to use and requires no knowledge of C++. The current use of GATE is in the medical imaging fi eld (using both external and internal sources) [20,21], dosimetry [22][23][24], radiotherapy (using photons and charged particles), and the newly added feature of optical imaging.…”

Section: Evolution Of Gatementioning

confidence: 99%

A virtual laboratory for radiotracer and sealed-source applications in industry

et al. 2021

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Radioactive sealed sources and radiotracer techniques are used to diagnose industrial process units. This work introduces a workspace to simulate four sealed sources and radiotracer applications, namely, gamma scanning of distillation columns, gamma scanning of pipes, gamma transmission tomography, and radiotracer flow rate measurements. The workspace was created in Geant4 Application for Tomographic Emission (GATE) simulation toolkit and was called Industrial Radioisotope Applications Virtual Laboratory. The flexibility of GATE and the fact that it is an open-source software render it advantageous to radioisotope technology practitioners, educators, and students. The comparison of the simulation results with experimental results that are available in the literature showed the effectiveness of the virtual laboratory.

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Does the setup of Monte Carlo simulations influence the calculated properties and effect of gold nanoparticles in radiation therapy?

Cited by 7 publications

References 16 publications

Actual questions raised by nanoparticle radiosensitization

Actual questions raised by nanoparticle radiosensitization

Investigation of the gold nanoparticles effects on the prostate dose distribution in brachytherapy: gel dosimetry and Monte Carlo method

A virtual laboratory for radiotracer and sealed-source applications in industry

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