Actual questions raised by nanoparticle radiosensitization

Brun, Émilie; Sicard-Roselli, Cécile

doi:10.1016/j.radphyschem.2016.05.024

Cited by 42 publications

(23 citation statements)

References 92 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, metal-based NanoEnhancers in tumor cells or organelles, such as mitochondria and endoplasmic reticulum (ER) 227 , can elicit unidentified cellular biochemical changes 228 - 230 leading to their radiosensitizing and synergistic effects in combination with ionizing radiations. Thus, the enhanced cell-killing effects might result from the complicated physical, chemical, and biological effects induced by the complex action of metal-based nanoparticles and ionizing radiation exposure 8 , 231 .…”

Section: Biological Contributions Of Metal-based Nanoenhancmentioning

confidence: 99%

“…In 1980, Matsudaira et al first demonstrated that iodine contrast medium could sensitize cultured cells to X-rays 7 . Subsequently, numerous studies investigating the radiosensitizing and synergistic effects of metal-based nanoparticles for radiotherapy, termed “ NanoEnhancers ”, have been reported in the past decades 8 . Photoelectrons and Auger electrons generated from the irradiated metal-based nanoparticles could contribute to the dose enhancement and subsequent radiobiological enhancement 9 , 10 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Metal-based NanoEnhancers for Future Radiotherapy: Radiosensitizing and Synergistic Effects on Tumor Cells

et al. 2018

View full text Add to dashboard Cite

Radiotherapy is one of the major therapeutic strategies for cancer treatment. In the past decade, there has been growing interest in using high Z (atomic number) elements (materials) as radiosensitizers. New strategies in nanomedicine could help to improve cancer diagnosis and therapy at cellular and molecular levels. Metal-based nanoparticles usually exhibit chemical inertness in cellular and subcellular systems and may play a role in radiosensitization and synergistic cell-killing effects for radiation therapy. This review summarizes the efficacy of metal-based NanoEnhancers against cancers in both in vitro and in vivo systems for a range of ionizing radiations including gamma-rays, X-rays, and charged particles. The potential of translating preclinical studies on metal-based nanoparticles-enhanced radiation therapy into clinical practice is also discussed using examples of several metal-based NanoEnhancers (such as CYT-6091, AGuIX, and NBTXR3). Also, a few general examples of theranostic multimetallic nanocomposites are presented, and the related biological mechanisms are discussed.

show abstract

Section: Biological Contributions Of Metal-based Nanoenhancmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Metal-based NanoEnhancers for Future Radiotherapy: Radiosensitizing and Synergistic Effects on Tumor Cells

et al. 2018

View full text Add to dashboard Cite

show abstract

“…The illustration of such a phenomenon has been highly documented for more than a decade both in vivo and in vitro (Hainfeld et al 2004) with a majority of studies combining radiation and cellular systems (Rosa et al 2017). Nevertheless, from this abundant literature, contradictory results emerged, as well as different explanations: for example, even non high-Z elements radiosensitization was evidenced (Grall et al 2015), and low-energy photons radiation does not seem to be the most efficient to radiosensitize (Brun and Sicard-Roselli 2016). Thus, no consensus could be established to propose an efficient combination of nanoparticle and radiation.…”

Section: Experimental Physico-chemical Approach Of Radiosensitizationmentioning

confidence: 99%

Importance of radiolytic reactions during high-LET irradiation modalities: LET effect, role of O2 and radiosensitization by nanoparticles

et al. 2019

Self Cite

View full text Add to dashboard Cite

Background It is striking how chemists and biologists showed an interest for ionizing radiations very soon after their discovery by Roentgen and Becquerel, and initiated parallel developments of these new fields of research: radiation chemistry and radiobiology. Radiation chemistry deals with the chemical effects produced when materials are exposed to ionizing radiations and begun long before 1942 when it was formally named by Burton (Magee 1988). Early pioneering works were achieved by Curie and Debierne in 1901 by observing gas bubbling out of radium salt solutions, Giesel in 1902 (Giesel 1902), Ramsay in 1903, and the progress and enthusiasm persisted throughout the beginning of 20th century (Debierne 1914; Kernbaum 1909

show abstract

“…The mechanism of cell death by ionizing radiation also involved all physical, chemical, and biological effects. 35 Byproducts of radiation interaction are the generation of reactive oxygen species (ROS), which includes both radical and non-radical species. The ROS was induced due to the breakage of the chemical bonds of tissue molecules, especially water molecules after the irradiation, leading to DNA, RNA, and protein damages.…”

Section: Introductionmentioning

confidence: 99%

<p>Synergetic Influence of Bismuth Oxide Nanoparticles, Cisplatin and Baicalein-Rich Fraction on Reactive Oxygen Species Generation and Radiosensitization Effects for Clinical Radiotherapy Beams</p>

Sisin¹,

Razak²,

Abidin³

et al. 2020

IJN

View full text Add to dashboard Cite

This study aimed to quantify synergetic effects induced by bismuth oxide nanoparticles (BiONPs), cisplatin (Cis) and baicalein-rich fraction (BRF) natural-based agent on the reactive oxygen species (ROS) generation and radiosensitization effects under irradiation of clinical radiotherapy beams of photon, electron and HDR-brachytherapy. The combined therapeutic responses of each compound and clinical radiotherapy beam were evaluated on breast cancer and normal fibroblast cell line. Methods: In this study, individual BiONPs, Cis, and BRF, as well as combinations of BiONPs-Cis (BC), BiONPs-BRF (BB) and BiONPs-Cis-BRF (BCB) were treated to the cells before irradiation using HDR brachytherapy with 0.38 MeV iridium-192 source, 6 MV photon beam and 6 MeV electron beam. The individual or synergetic effects from the application of the treatment components during the radiotherapy were elucidated by quantifying the ROS generation and radiosensitization effects on MCF-7 and MDA-MB-231 breast cancer cell lines as well as NIH/3T3 normal cell line. Results: The ROS generated in the presence of Cis stimulated the most substantial amount of ROS compared to the BiONPs and BRF. Meanwhile, the combination of the components had induced the higher ROS levels for photon beam than the brachytherapy and electron beam. The highest ROS enhancement relative to the control is attributable to the presence of BC combination in MDA-MB-231 cells, in comparison to the BB and BCB combinations. The radiosensitization effects which were quantified using the sensitization enhancement ratio (SER) indicate the highest value by BC in MCF-7 cells, followed by BCB and BB treatment. The radiosensitization effects are found to be more prominent for brachytherapy in comparison to photon and electron beam. Conclusion: The BiONPs, Cis and BRF are the potential radiosensitizers that could improve the efficiency of radiotherapy to eradicate the cancer cells. The combination of these potent radiosensitizers might produce multiple effects when applied in radiotherapy. The BC combination is found to have the highest SER, followed by the BCB combination. This study is also the first to investigate the effect of BRF in combination with BiONPs (BB) and BC (BCB) treatments.

show abstract

Actual questions raised by nanoparticle radiosensitization

Cited by 42 publications

References 92 publications

Metal-based NanoEnhancers for Future Radiotherapy: Radiosensitizing and Synergistic Effects on Tumor Cells

Metal-based NanoEnhancers for Future Radiotherapy: Radiosensitizing and Synergistic Effects on Tumor Cells

Importance of radiolytic reactions during high-LET irradiation modalities: LET effect, role of O2 and radiosensitization by nanoparticles

<p>Synergetic Influence of Bismuth Oxide Nanoparticles, Cisplatin and Baicalein-Rich Fraction on Reactive Oxygen Species Generation and Radiosensitization Effects for Clinical Radiotherapy Beams</p>

Contact Info

Product

Resources

About