Does the route of administration of misoprostol make a difference? The uterotonic effect and side effects of misoprostol given by different routes after vaginal delivery

Chong, Yap Seng; Chua, S.; Shen, Liang; Arulkumaran, Sabaratnam

doi:10.1016/j.ejogrb.2003.09.011

Cited by 38 publications

(45 citation statements)

References 37 publications

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“…In the pharmacokinetic study by Tang et al [4], the peak plasma level of misoprostol acid was highest and earliest with sublingual misoprostol. Misoprostol tablets dissolved in water and taken orally have also been shown to produce a faster onset and stronger uterotonic effect than by oral tablet or rectal administration [19,20]. This information has important significance in the clinical setting because it helps clinicians decide the most effective regime for each individual purpose.…”

Section: Pharmakokinetics Of Misoprostolmentioning

confidence: 95%

Misoprostol for labor induction in term pregnancy

Surbek

2007

Eur Clinics Obstet Gynaecol

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Misoprostol has been used off-label for labor induction for many years. A large number of randomized controlled studies have assessed the efficacy and safety of misoprostol in different dose ranges between 10 and 100 mcg, with different dose intervals and different administration routes including oral, intravaginal, rectal, sublingual, and buccal administration. Currently, registration trials are underway, and misoprostol for registered indication of labor induction might be available in several European countries in the near future. Meanwhile, guidelines for off-label use should be provided by authorities or OB/GYN associations.

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Section: Pharmakokinetics Of Misoprostolmentioning

confidence: 95%

Misoprostol for labor induction in term pregnancy

Surbek

2007

Eur Clinics Obstet Gynaecol

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“…Common side effects of misoprostol when used in prevention or treatment of PPH include shivering, fever, diarrhoea, and abdominal pain. Shivering (up to 76%) and fever have been reported with the use of misoprostol in the third stage of labour [7][8][9]. As with other prostaglandins, the rate of adverse effects is related to factors such as dose and route of administration.…”

Section: Misoprostolmentioning

confidence: 95%

Misoprostol in the management of postpartum haemorrhage

Feitsma

Kanhai

2005

International Congress Series

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“…9,10 The effectiveness of Misoprostol in reducing blood loss and preventing PPH has been proved by various studies. 10,11 But the most effective route has not been established yet. …”

Section: Discussionmentioning

confidence: 99%

“…9 It has numerous advantages as it can be administered through various routes orally, rectally, sublingually or Vaginal route. 10,11 It is easy to store and stable at room temperature. Many studies have established the efficacy of the prophylactic use of Misoprostol for reduction of blood loss after delivery when compared to conventional syntocinon, methylergometrine.…”

Section: Introductionmentioning

confidence: 99%

A comparative study of different route of administration of misoprostol in the management of third stage of labour

Sreelatha

Nethra

Nadagoudar

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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INTRODUCTIONThird stage of labour begins after the delivery of the fetus till the expulsion of the placenta and membranes. 1 Though the third stage constitutes short span of time, it is the phase of maximum maternal mortality and morbidity.One of the major hazards being post partum haemorrhage. PPH complicates approximately 4% of vaginal deliveries and 6% of caesarean deliveries. WHO statistics suggest 30% of maternal deaths worldwide with an estimated 1.25 million cases and morbidity in 20 million women annually are due to PPH. 2,3Uterine atony is the most common cause constituting about 80-90% of cases.4 So, we have to aim at increasing the tone of the uterus by using uterotonic drugs to reduce PPH. Various uterotonic drugs is available like Oxytocin, Ergometrine, Prostaglandins.5 To prevent and treat PPH, literature strongly suggests the use of active management of 3rd stage 6 which includes use of Oxytocin at the time of delivery of anterior shoulder, controlled cord traction, ABSTRACT Background: Post partum haemorrhage is the most common cause of maternal morbidity and mortality. Misoprostol is a prostaglandin analogue, used for management of post partum haemorrhage. It can be used by various routes with minimal side effects. This study is done to compare the different routes of administration of Misoprostol for the third stage management and their side effects. Objectives of present study were to estimate the amount of blood loss, to assess the maternal side effects of drug, to know the haemoglobin deficit, to know the duration of third stage of labour. Methods: This was a prospective hospital base study of 150 women delivery at obstetrics and gynaecology department at ESICMC Model Hospital, Rajajinagar. They were randomized into 3 groups of 50 patients each. They received 400 µg of misoprostol either orally or rectally or sublingually immediately after delivery of the fetus. The primary outcomes analysed were amount of blood loss duration of third stage of labour haemoglobin deficit and their side effects Results: The amount of blood loss and haemoglobin deficit was least in sublingual group which was statistically significant. Need of additional oxytocics was less in sublingual and oral group, though it was not statistically significant. Conclusions: In the present study, sublingual Misoprostol was found to be more effective in reducing blood loss during third stage of labour.

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Does the route of administration of misoprostol make a difference? The uterotonic effect and side effects of misoprostol given by different routes after vaginal delivery

Cited by 38 publications

References 37 publications

Misoprostol for labor induction in term pregnancy

Misoprostol for labor induction in term pregnancy

Misoprostol in the management of postpartum haemorrhage

A comparative study of different route of administration of misoprostol in the management of third stage of labour

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