Misoprostol for labor induction in term pregnancy

Abstract

Misoprostol has been used off-label for labor induction for many years. A large number of randomized controlled studies have assessed the efficacy and safety of misoprostol in different dose ranges between 10 and 100 mcg, with different dose intervals and different administration routes including oral, intravaginal, rectal, sublingual, and buccal administration. Currently, registration trials are underway, and misoprostol for registered indication of labor induction might be available in several European countries in the near future. Meanwhile, guidelines for off-label use should be provided by authorities or OB/GYN associations.

TO COMPARE THE FETOMATERNAL OUTCOME OF ORAL MISOPROSTOL SOLUTION AND VAGINAL MISOPROSTOL TABLET FOR INDUCTION OF LABOUR AT TERM IN THE DEPARTMENT OF OBSTETRICS & GYNAECOLOGY, SMS MEDICAL COLLEGE, JAIPUR

“…It was manufactured for the treatment of peptic ulcer disease. 1,10 Though unlicensed by the Federal Drug Authority for this purpose, 11 Misoprostol is now increasingly and successfully being used for labour induction, with vaginal as well as oral routes. 7,12,13 It is economical, stable at room temperature, has easy handling and storage, rapid absorption and high potency.…”

“…7,12,13 It is economical, stable at room temperature, has easy handling and storage, rapid absorption and high potency. 1,10 There is no evidence that oral misoprostol is inferior to the vaginal one and it has lower rates of uterine hyperstimulation because the total systemic bioavailability of orally administered misoprostol is three times lesser than that of vaginally administered misoprostol. 13 In order to avoid uterine hyperstimulation, current suggestions are in favor of oral misoprostol given in small, frequent doses, titrated according to uterine response.…”