Does systemic inflammation trigger local exercise-induced oxidative stress in COPD?

Koechlin, Christelle; Couillard, A.; Cristol, Jean Paul; Chanez, Pascal; Hayot, Maurice; Gallais, Daniel Le; Préfaut, Christian

doi:10.1183/09031936.04.00069004

Cited by 84 publications

(94 citation statements)

References 38 publications

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“…In a sample of 10 subjects who had COPD, plasma levels of products of oxidative stress were increased significantly over similar products formed by seven controls at 6 hours after one episode of quadriceps endurance activity. Nonenzymatic antioxidants and inflammatory cytokine levels were unchanged by exercise immediately after and up to 48 hours after quadriceps endurance activity [97]. In this study, proinflammatory cytokines in plasma remained unchanged up to 6 hours after one episode of exercise.…”

Section: Oxidants Cytokines and Activitymentioning

confidence: 50%

Inactivity and Inflammation in the Critically Ill Patient

Winkelman

2007

Critical Care Clinics

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Section: Oxidants Cytokines and Activitymentioning

confidence: 50%

Inactivity and Inflammation in the Critically Ill Patient

Winkelman

2007

Critical Care Clinics

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“…KOECHLIN et al [25] found that CRP levels inversely correlated with endurance time. BROEKHUIZEN et al [23] also found that CRP increases in patients with poor exercise capacity.…”

Section: Discussionmentioning

confidence: 99%

C-reactive protein levels and clinically important predictive outcomes in stable COPD patients

de-Torres¹,

Córdoba-Lanús²,

et al. 2006

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The aim of this study was to determine the relationship between C-reactive protein (CRP) levels and factors known to predict outcome in stable chronic obstructive pulmonary disease (COPD) patients.The following were studied in 130 stable COPD patients: spirometry, lung volume, arterial oxygen tension (Pa,O 2 ), dyspnoea, 6-min walk distance (6MWD), body mass index, fat-free mass index, BODE (body mass index, obstruction, dyspnoea and exercise capacity), health-related quality of life, smoking status, the presence of cardiovascular risk factors or disease, corticosteroid use and number of exacerbations in the previous year. CRP levels were measured in these patients and in 65 controls. Using univariate and multivariate analyses, any possible association with the predictors of outcomes was evaluated.CRP levels were higher in COPD patients than in controls (4.1 versus 1.8 mg?L C-reactive protein levels in stable chronic obstructive pulmonary disease patients are best correlated with arterial oxygen tension and 6-min walk distance. This should be considered when C-reactive protein levels are measured in stable chronic obstructive pulmonary disease patients.

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“…In particular, this has been demonstrated in patients with COPD during exercise [107,108]. Physical exercise specifically increases plasma TNF-a levels in COPD [109].…”

Section: Underlying Mechanisms and Consequences For Treatment Of Compmentioning

confidence: 97%

Complex chronic comorbidities of COPD

Fabbri¹,

Luppi²,

Beghè³

et al. 2008

European Respiratory Journal

559

401

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Chronic obstructive pulmonary disease (COPD) is defined by fixed airflow limitation associated with an abnormal pulmonary and systemic inflammatory response of the lungs to cigarette smoke.The systemic inflammation induced by smoking may also cause chronic heart failure, metabolic syndrome and other chronic diseases, which may contribute to the clinical manifestations and natural history of COPD. Thus COPD can no longer be considered a disease only of the lungs, as it is often associated with a wide variety of systemic consequences.A better understanding of the origin and consequences of systemic inflammation, and of potential therapies, will most likely lead to better care of patients with COPD. Medical textbooks and clinical guidelines still largely ignore the fact that COPD seldom occurs in isolation.As the diagnosis and assessment of severity of COPD may be greatly affected by the presence of comorbid conditions, the current authors believe that lung function measurement, noninvasive assessment of cardiovascular and metabolic functions, and circulating inflammatory markers (e.g. C-reactive protein) might help to better characterise these patients. Similarly, preventive and therapeutic interventions should address the patient in their complexity.

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Does systemic inflammation trigger local exercise-induced oxidative stress in COPD?

Cited by 84 publications

References 38 publications

Inactivity and Inflammation in the Critically Ill Patient

Inactivity and Inflammation in the Critically Ill Patient

C-reactive protein levels and clinically important predictive outcomes in stable COPD patients

Complex chronic comorbidities of COPD

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