Does simvastatin affect mood and steroid hormone levels in hypercholesterolemic men? A randomized double-blind trial

Hyyppä, Markku T.; Kronholm, Erkki; Virtanen, Arja; Leino, Aila; Jula, Antti

doi:10.1016/s0306-4530(02)00014-8

Cited by 105 publications

(107 citation statements)

References 27 publications

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“…Statin treatment was shown to increase the tendency for depression; for example, simvastatin was shown to increase depression level significantly but did not affect anxiety level (Hyyppa et al 2003). In another study, depressive patients refractory to antidepressant treatment had significantly increased blood cholesterol level (Papakostas et al 2003).…”

Section: Discussionmentioning

confidence: 99%

Association between Depression and Anxiety Symptoms and Major Atherosclerosis Risk Factors in Patients with Chest Pain

Vural¹,

Şatıroğlu²,

Akbas

et al. 2007

Tohoku J. Exp. Med.

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Psychological variables, such as depression and anxiety, are known as independent risk factors for coronary artery disease (CAD), suggesting the interaction of psychological and physiological factors in the development of CAD. In the present study, we analyzed the possible association between depressive and anxiety symptoms and major atherosclerotic risk factors in patients with chest pain warranting coronary angiography. The patients without CAD (n = 159) and those with CAD (n = 155) were evaluated for the severity of depression and anxiety by the symptom scales; high scores indicate severe symptoms. Age, male/female ratio, prevalence of diabetes mellitus (DM), and depression level were significantly higher in the CAD group. Among a total of 314 patients with chest pain, the mean depression score was higher in patients with DM (16.01 ± 8.12 vs 13.01 ± 9.6, p = 0.01) and those with hypercholesterolemia (15.43 ± 9.61 vs 12.53 ± 9.61, p = 0.02). The mean anxiety score was also higher in patients with DM (20.81 ± 12.85 vs 16.51 ± 12.09, p = 0.008), hypercholesterolemia (20.67 ± 13.11 vs 15.29 ± 11.36, p = 0.002), or hypertension (20.74 ± 12.94 vs 14.1 ± 10.8, p = 0.001). Thus, DM and hypercholesterolemia are associated with depression and anxiety, while hypertension is only related to anxiety. In contrast, smoking and family history of atherosclerosis are not related to depression and anxiety scores. These results suggest depression and anxiety symptoms may contribute to the development and progression of CAD, especially in patients with DM or hypercholesterolemia.depression; anxiety; psychological tests; atherosclerosis risk factors; coronary artery disease

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Section: Discussionmentioning

confidence: 99%

Association between Depression and Anxiety Symptoms and Major Atherosclerosis Risk Factors in Patients with Chest Pain

Vural¹,

Şatıroğlu²,

Akbas

et al. 2007

Tohoku J. Exp. Med.

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“…Reports of adverse mood effects of cholesterol reduction generally derive from relatively small studies. 15,35,36 With respect to aggression and violent behavior, a variety of observational studies have found, compared with that of controls, lower mean TC concentrations in violent criminals, violent psychiatric patients, individuals with antisocial personality disorder, and the victims of death from suicides, accidents, and violence. [1][2][3][4][5][37][38][39] As noted earlier, in placebo-controlled clinical trails, deaths from suicides, accidents, and violence may be increased by diet modifications and older cholesterol-lowering medications, but such does not appear to occur with statin drugs.…”

Section: Discussionmentioning

confidence: 99%

Lipid-Lowering Medication Use and Aggression Scores in Women: A Report from the NHLBI-Sponsored WISE Study

Olson

Kelsey

Matthews

et al. 2008

Journal of Women's Health

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Aim-The aim of this study was to examine the association between the use of lipid-lowering medication and aggressive responding, hostility, cynicism, and depression scores in women undergoing coronary angiography.Methods-The cohort included 498 women from the National Heart, Lung and Blood Institute (NHLBI)-sponsored Women's Ischemia Syndrome Evaluation (WISE) study. WISE is a four-center study of women with chest pain who underwent quantitative coronary angiography for suspected myocardial ischemia. The psychosocial indices included the Cook Medley Hostility questionnaire, measuring aggression, hostility, and cynicism, and the Beck Depression Inventory (BDI).Results-Compared to those not on lipid-lowering medication, women receiving lipid-lowering pharmacotherapy were older (62 vs. 55 years, p < 0.001) and had more hypertension, dyslipidemia, diabetes, and coronary artery disease (CAD, defined as ≥50% stenoses in at least one epicardial artery) (all p < 0.003). Women on lipid-lowering medication had higher aggressive responding scores than those not on medication, 3.0 ± 1.8 vs. 2.7 ± 1.7, respectively (age-adjusted p < 0.003). This association persisted after adjustment for coronary risk factors, education, and extent of angiographic disease (CAD) (p < 0.005), and after exclusion of women using psychotropic medications (p < 0.001). Hostility, cynicism, and depression scores did not differ by medication use.Conclusions-In women, lipid-lowering medication may predispose to aggression without affecting hostility or mood, but this hypothesis requires evaluation in placebo-controlled clinical trials.

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“…The effects of treatment with statins on sex hormone levels have been addressed in multiple publications, but the results of these studies are equivocal [2][3][4][5][8][9][10][11][12].…”

Section: Statins and Total Testosterone Levelsmentioning

confidence: 99%

“…Two double-blind studies investigating the effect of statin treatment on total testosterone levels have been published, a study by Dobs et al and a study by Hyyppa et al, both having been conducted in patients with hypercholesterolaemia without other co-morbidities [3,4]. A total of 81 patients participated in the study by Dobs et al, including 39 men receiving placebo and 41 men being treated by simvastatin for 12 weeks at the dose of 80 mg/day, i.e.…”

Section: Statins and Testosteronementioning

confidence: 99%

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Terapia z wykorzystaniem statyn a stężenie testosteronu u mężczyzn

Mędraś

Kubicka

Jóźków

et al. 2015

Endokrynologia Polska

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Introduction: Statins belong to the most commonly used medicines worldwide. They affect cholesterol synthesis and thus they may suppress steroidogenesis. Our aim was to evaluate whether the use of statins is associated with the concentration of sex hormones. Material and methods/Results: In a population sample of men (n = 237) we found that subjects receiving statins had significantly lower concentrations of: total testosterone (14.9 vs. 16.35 nmol/L, p = 0.008 after correction for body mass), free testosterone (32 vs. 39 pmol/L, p = 0.004), calculated free testosterone (0.32 vs. 0.36 nmol/L, p < 0.001) and bioavailable testosterone (6.10 vs. 7.56 nmol/L, p < 0.001) than age-matched controls. Conclusions:We conclude that the use of statins may have an impact on the diagnosis of age-related testosterone deficiency in men.

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Does simvastatin affect mood and steroid hormone levels in hypercholesterolemic men? A randomized double-blind trial

Cited by 105 publications

References 27 publications

Association between Depression and Anxiety Symptoms and Major Atherosclerosis Risk Factors in Patients with Chest Pain

Association between Depression and Anxiety Symptoms and Major Atherosclerosis Risk Factors in Patients with Chest Pain

Lipid-Lowering Medication Use and Aggression Scores in Women: A Report from the NHLBI-Sponsored WISE Study

Terapia z wykorzystaniem statyn a stężenie testosteronu u mężczyzn

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