Terapia z wykorzystaniem statyn a stężenie testosteronu u mężczyzn

Mędraś, M; Kubicka, Eliza; Jóźków, Paweł; Słowińska-Lisowska, Małgorzata; Trzmiel-Bira, Anna; Filus, Alicja

doi:10.5603/ep.2014.0064

Cited by 8 publications

(6 citation statements)

References 26 publications

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“…Differences in genetic background, diet, levels of physical activity and sex structure also influence the prevalence of both MS and its components [28]. Inhibin B is the physiological feedback signal for FSH and a serum marker of Sertoli cell function, predicting semen quality and male factor infertility [25,29,30]. Testosterone on the other hand is a serum marker of Leydig cell function and the physiological feedback signal for LH.…”

Section: Discussionmentioning

confidence: 99%

Inhibin B Levels in Relation to Obesity Measures and Lipids in Males with Different Numbers of Metabolic Syndrome Components

Laniyan¹,

Charles-Davies²,

Fasanmade³

et al. 2016

JSRR

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Introduction: Defective spermatogenesis and metabolic syndrome affect 2-4% and 12.4% of males respectively. Deficient testosterone levels due to increased conversion of testosterone to oestradiol have been demonstrated in males with the metabolic syndrome (MS) with limited pituitary and leptin contribution. Defective spermatogenesis is thus implicated in males with MS but is controversial. Inhibin B is a marker of spermatogenesis. This study aims at evaluating inhibin B levels and their relationship with obesity measures and lipids in males with different number of MS components. Materials and Methods: This is a preliminary prospective study in which a total of 106 apparently healthy males (30, 30, 30 and 16 males with 0, 1, 2 and ≥3 components of metabolic syndrome (NMSC) respectively) aged 19-64 years were purposely selected. Blood pressure (BP) and obesity measures (including visceral adiposity index (VAI) and body mass index (BMI)) were obtained by standard methods. Fasting plasma glucose (FPG), total cholesterol (TC), triglycerides and high density lipoprotein cholesterol (HDLC) were determined by enzymatic methods while low density lipoprotein cholesterol (LDLC) and the lipid ratios (TG/HDLC, TC/HDLC, LDLC/HDLC) were calculated. Inhibin B was analysed by enzyme linked immunosorbent assay (RayBiotech, Inc. USA). Data analysed using analysis of variance (ANOVA) and multiple regressions were significant at P <.05. Results: Inhibin B decreased significantly in males with 0 to 2 NMSC (P <.05). However, inhibin levels between males with 0 and ≥3 NMSC were similar. Age and inhibin B levels were also similar among the different classes of BMI (P>0.05). Inhibin B related positively with HDLC and TC but negatively with VAI, LDLC and TC/HDLC. Conclusion: Reproductive function appears protected in Nigerian males with MS. However, improvement in HDLC, LDLC, TC levels, VAI and TC/HDLC may enhance fertility potential especially in males with one or two MS components, probably through dietary modulation and physical activity.

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Section: Discussionmentioning

confidence: 99%

Inhibin B Levels in Relation to Obesity Measures and Lipids in Males with Different Numbers of Metabolic Syndrome Components

Laniyan¹,

Charles-Davies²,

Fasanmade³

et al. 2016

JSRR

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“…However, as the clinical emphasis of personalized therapy when statins are applied to hypogonadal individuals, increasing bodies of evidence have captured attention to their side effects. In fact, statins were reported to exacerbate androgen deficiency by reducing peripheral ARs [33] or directly lowering serum testosterone levels [34] due to Leydig cells' selective uptake of cholesterol from the de novo synthesis as ingredients of steroidogenesis [35], which raises the urgent need of an alternate therapy. Our study accentuates the role of PCSK9 in the pathogenesis of hypercholesteremia in testosterone-deficient individuals indicating potential value of PCSK9 inhibitors when targeting the hypogonadal patients.…”

Section: Discussionmentioning

confidence: 99%

Testosterone Deficiency Promotes Hypercholesteremia and Attenuates Cholesterol Liver Uptake via AR/PCSK9/LDLR Pathways

Zhiqi

Chen

et al. 2022

International Journal of Endocrinology

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Background. Testosterone deficiency is reportedly correlated with an elevation of cholesterol in plasma, but the mechanism remains unclear. Our objective was to investigate the effects of testosterone deficiency on cholesterol metabolism and the corresponding molecular changes in vivo and in vitro. Methods. SD rats were randomized into three groups: sham-operated (SHAM), subtotal orchiectomized (SO), and orchiectomized (ORX) and fed for 8 weeks. HepG2 cells were cultured with medium containing testosterone with the final concentrations of 0, 10, 30, and 300 nM. Method of isotope tracing and fluorescence labelling was adopted to investigate cholesterol metabolism. Several key molecules of cholesterol metabolism were also analyzed. Results. SO and ORX rats displayed dysfunctional liver uptake of cholesterol. HepG2 cells incubated with testosterone of lower and excessive level exhibited reduced capacity of cholesterol uptake. Further investigation revealed that lack of testosterone induced increased proprotein convertase subtilisin/kexin type 9 (PCSK9) and decreased low-density lipoprotein receptor (LDLR) both in vivo and in vitro. Moreover, the androgen receptor (AR) antagonist flutamide mimicked the effects of testosterone deficiency on PCSK9 and LDLR indicating the role of AR as a mediator in triggering attenuating liver cholesterol uptake in which testosterone instead of dihydrotestosterone (DHT) is the major functional form of androgen. Conclusion. Testosterone deficiency attenuated cholesterol liver uptake mediated by the PCSK9-LDLR pathway, in which AR and testosterone without transforming to DHT play important roles.

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“…WHO zwraca uwagę, że nawet połowę produktów leczniczych dostępnych w internecie mogą stanowić produkty sfałszowane 13 . Wskazuje się również, że polskojęzyczne domeny, na których można nabyć takie produkty, rejestrowane są na zagranicznych serwerach 14 , co w zasadniczym stopniu utrudnia walkę z tym fenomenem.…”

Section: Wprowadzenieunclassified

“…13 Sfałszowane produkty lecznicze, https://www.gov.pl/web/zdrowie/sfalszowane-produkty-lecznicze (dostęp: 18.01.2022 r.). 14 Raport o stanie bezpieczeństwa w Polsce w 2016 r., Warszawa 2017, s. 145.…”

Section: Cel Analizyunclassified

“…Tytułem przykładu warto odnieść się do sfałszowanych produktów leczniczych, w których składzie występują steroidy anaboliczne. Podkreśla się, że ich stosowanie może zaburzać prawidłową gospodarkę hormonalną i prowadzić do bardzo poważnych następstw zdrowotnych, poczynając od nadmiernego owłosienia na obszarach androgenowrażliwych u kobiet i braku miesiączki oraz zaburzenia spermatogenezy u mężczyzn 25 , co niewątpliwie generuje poważne problemy z płodnością 26 , kończąc na uszkodzeniu zastawek serca, tętnic obwodowych oraz zaburzeniach w funkcjonowaniu układu immunologicznego 27 .…”

Section: Charakterystyka Ustawowych Znamion Przestępstw Z Art 124 I 1...unclassified

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Refleksje wokół prawnokarnej oceny fałszowania produktów leczniczych oraz wprowadzania ich do obrotu

Wojewoda¹

2022

PwD

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Pharmaceutical crime poses a huge challenge both to the national legislators and the international community. We have recently observed a particular development of this phenomenon, also due to the outbreak of the Covid-19 pandemic. The specific nature of pharmaceutical crime determines that in the case of irregularities in the marketing of medicinal products, we may have to deal with several regimes of liability – administrative, civil, criminal as well as professional one. On the penal level, the provisions grouped in the Criminal Code and the Pharmaceutical Law will be of fundamental importance. Correct classification of counterfeiting of medicinal products and their marketing may raise practical doubts which are based on the establishment of mutual relations between provisions – Article 165 paragraph 1 point 2 of the Penal Code and non-Code regulations found in the pharmaceutical law and extra-code regulations contained in the pharmaceutical law.

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Terapia z wykorzystaniem statyn a stężenie testosteronu u mężczyzn

Cited by 8 publications

References 26 publications

Inhibin B Levels in Relation to Obesity Measures and Lipids in Males with Different Numbers of Metabolic Syndrome Components

Inhibin B Levels in Relation to Obesity Measures and Lipids in Males with Different Numbers of Metabolic Syndrome Components

Testosterone Deficiency Promotes Hypercholesteremia and Attenuates Cholesterol Liver Uptake via AR/PCSK9/LDLR Pathways

Refleksje wokół prawnokarnej oceny fałszowania produktów leczniczych oraz wprowadzania ich do obrotu

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