Does Resveratrol Improve Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)?

Kasprzak-Drozd, Kamila; Niziński, Przemysław; Kasprzak, Paulina; Kondracka, Adrianna; Oniszczuk, Tomasz; Rusinek, Agata; Oniszczuk, Anna

doi:10.3390/ijms25073746

Cited by 4 publications

(1 citation statement)

References 121 publications

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“…Resveratrol's antioxidant [17,18], anti-inflammatory [19,20], antibacterial [21], cardioprotective [22,23], anti-cancer [24,25], and potential anti-aging and neuroprotective [26] properties are widely discussed in recent scientific research. The field continues to evolve as researchers uncover new insights into resveratrol's metabolism, biological activity, and therapeutic potential for human health [27][28][29]. The typical dietary intake of resveratrol from these sources is relatively low, usually less than 1 mg per day, significantly lower than the doses commonly used in research studies.…”

Section: Introductionmentioning

confidence: 99%

Retaining Resveratrol Content in Berries and Berry Products with Agricultural and Processing Techniques: Review

Ispiryan,

Kraujutiene,

Viskelis

2024

Processes

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Resveratrol is a natural compound that can be found in red wine, grapes, and berries. It has attracted attention due to its potential health benefits. The aim of this review was to align ways of retaining resveratrol contents in berries and products made of berries, and to show which agricultural and processing techniques can maximize the content in the berries and their products and how this can be achieved. The scientific literature has revealed that resveratrol concentration in berries and berry-derived products varies significantly depending on the source and the processing techniques applied. Resveratrol content can range from 0.03–0.06 mg/kg in blueberries to 5–10 mg/kg in grape skins. Agricultural techniques such as controlled water stress (e.g., increasing resveratrol in grapes to 8.3–11.5 mg/kg), optimal sun exposure (e.g., enhancing blueberries to 1.5–2.1 mg/kg), balanced nutrient management, and selecting high-resveratrol cultivars (e.g., up to 15 mg/kg in certain grapes) can substantially increase resveratrol content. Processing methods like cold pressing, centrifugation, ultrafiltration, and freeze-drying are effective in preserving resveratrol levels, while traditional pasteurization tends to reduce its concentration. For instance, high-temperature short-time pasteurization can reduce resveratrol in juice from 1.5 mg/kg to 0.8 mg/kg, whereas cold pressing retains more resveratrol (1.5 mg/kg to 1.4 mg/kg). By optimizing these agricultural and processing techniques, manufacturers can enhance the resveratrol content in berry-derived products, meeting the growing consumer demand for health-enhancing natural products and supporting a healthier society. This approach aligns with the commitment to overcoming the technical challenges associated with resveratrol use, ensuring its potential is fully realized in both health-related and non-health-related applications.

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Section: Introductionmentioning

confidence: 99%

Retaining Resveratrol Content in Berries and Berry Products with Agricultural and Processing Techniques: Review

Ispiryan,

Kraujutiene,

Viskelis

2024

Processes

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Green Tea Polyphenol (-)-Epicatechin Pretreatment Mitigates Hepatic Steatosis in an In Vitro MASLD Model

Hefer,

Petrovic,

Roguljic

et al. 2024

CIMB

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Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD), is becoming more prominent globally due to an increase in the prevalence of obesity, dyslipidemia, and type 2 diabetes. A great deal of studies have proposed potential treatments for MASLD, with few of them demonstrating promising results. The aim of this study was to investigate the potential effects of (-)-epicatechin (EPI) on the development of MASLD in an in vitro model using the HepG2 cell line by determining the metabolic viability of the cells and the levels of PPARα, PPARγ, and GSH. HepG2 cells were pretreated with 10, 30, 50, and 100 μM EPI for 4 h to assess the potential effects of EPI on lipid metabolism. A MASLD cell culture model was established using HepG2 hepatocytes which were exposed to 1.5 mM oleic acid (OA) for 24 h. Moreover, colorimetric MTS assay was used in order to determine the metabolic viability of the cells, PPARα and PPARγ protein levels were determined using enzyme-linked immunosorbent assay (ELISA), and lipid accumulation was visualized using the Oil Red O Staining method. Also, the levels of intracellular glutathione (GSH) were measured to determine the level of oxidative stress. EPI was shown to increase the metabolic viability of the cells treated with OA. The metabolic viability of HepG2 cells, after 24 h incubation with OA, was significantly decreased, with a metabolic viability of 71%, compared to the cells pretreated with EPI, where the metabolic viability was 74–86% with respect to the concentration of EPI used in the experiment. Furthermore, the levels of PPARα, PPARγ, and GSH exhibited a decrease in response to increasing EPI concentrations. Pretreatment with EPI has demonstrated a great effect on the levels of PPARα, PPARγ, and GSH in vitro. Therefore, considering that EPI mediates lipid metabolism in MASLD, it should be considered a promising hepatoprotective agent in future research.

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Protective and Detoxifying Effects of Resveratrol on Zearalenone-Mediated Toxicity: A Review

Lv,

Xu,

Yang

et al. 2024

IJMS

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Zearalenone (ZEA) is a mycotoxin produced by Fusarium spp. fungi and is widely found in moldy corn, wheat, barley, and other grains. ZEA is distributed to the whole body via blood circulation after metabolic transformation in animals. Through oxidative stress, immunosuppression, apoptosis, autophagy, and mitochondrial dysfunction, ZEA leads to hepatitis, neurodegenerative diseases, cancer, abortion, and stillbirth in female animals, and decreased sperm motility in male animals. In recent years, due to the influence of climate, storage facilities, and other factors, the problem of ZEA pollution in global food crops has become particularly prominent, resulting in serious problems for the animal husbandry and feed industries, and threatening human health. Resveratrol (RSV) is a natural product with therapeutic activities such as anti-inflammatory, antioxidant, and anticancer properties. RSV can alleviate ZEA-induced toxic effects by targeting signaling pathways such as NF-κB, Nrf2/Keap1, and PI3K/AKT/mTOR via attenuating oxidative damage, inflammatory response, and apoptosis, and regulating cellular autophagy. Therefore, this paper provides a review of the protective effect of RSV against ZEA-induced toxicity and its molecular mechanism, and discusses the safety and potential clinical applications of RSV in the search for natural mycotoxin detoxification agents.

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Does Resveratrol Improve Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)?

Cited by 4 publications

References 121 publications

Retaining Resveratrol Content in Berries and Berry Products with Agricultural and Processing Techniques: Review

Retaining Resveratrol Content in Berries and Berry Products with Agricultural and Processing Techniques: Review

Green Tea Polyphenol (-)-Epicatechin Pretreatment Mitigates Hepatic Steatosis in an In Vitro MASLD Model

Protective and Detoxifying Effects of Resveratrol on Zearalenone-Mediated Toxicity: A Review

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