Does red ginseng ameliorate liver damage caused by obstructive jaundice? : an experimental study

Abstract

Aim: This experimental study aimed to evaluate the hepatoprotective effect on obstructive jaundice (OJ) of oral Red Ginseng (RG) extract, which is known to have anti-inflammatory and antioxidant properties. Material and Method: The rats were randomly separated into 3 groups of 10 rats: The sham group, the control group, and the treatment group. In Group 1 (sham), the common bile duct (CBD) was identified but no ligation or transection was performed. In Group 2 (control), the CBD was identified and ligation and transection were performed, but no treatment was given. In Group 3 (RG group), CBD ligation and transection were performed, then RG extract was administered via an orogastric tube at a dose of 100 mg/ kg/day for 10 days. After 10 days, blood samples were taken for biochemical analysis, and liver tissue samples for biochemical and histopathological analysis. Results: Significantly higher serum albumin levels and lower serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were determined in the RG group than in the control group (p=0.028, p=0.001 and p=0.034, respectively). In the oxidative stress parameters, malondialdehyde (MDA) levels and catalase (CAT) levels were significantly different between the RG group and control group (p≤0.001 for each). Total sulfhydryl (T-SH) was not at a statistically significant level, although it was high and approached the value of the sham group (p=0.076). In the histopathological evaluation, the RG group had statistically significantly lower scores in all parameters compared to the control group (p<0.05). Conclusion:The results of this study showed that RG has a strong hepatoprotective effect as a result of its anti-inflammatory and antioxidant properties.

Ratlarda Splenektomi Sonrası Red Ginsengin Lipit Profili, Endotel ve Oksidatif Hasar Üzerinde Koruyucu Etkisinin Değerlendirilmesi

“…Durhan et al created a mechanical icterus model in rats and demonstrated the anti-inflammatory and antioxidant effects of RG. In their study, they showed that RG significantly decreased MDA values, which indicates intracellular oxidative stress, and significantly increased the level of catalase, which is an important antioxidant [31]. Another study showing the antioxidant effect of RG is the study of Cho et al They showed that the use of RG in lung injury caused by mechanical ventilation in rats significantly decreased MDA values [32].…”

Does Rectal Application of Red-Ginseng have an Effect on Colorectal Anastomosis Healing? An Experimental Study

“…Considering the mechanism of action of ginsenosides, anti-inflammatory effects have been proven by purifying ginsenosides. Expressions of pro-inflammatory cytokines (TNF-alpha, IL-1 and IL-6) have been shown to induce M1 and M2 polarization of macrophages or microglia while inhibiting iNOS and COX-2 enzyme expressions, which was found to be the anti-inflammatory mechanism of ginsenosides [17]. In a study by Kosmaz et al, red ginseng was given to rats that underwent splenectomy, and its antioxidant and anti-inflammatory activity was demonstrated.…”

“…In that study, red ginseng was shown to have significantly reduced MDA values, which indicate intracellular oxidative stress, and significantly increased the level of catalase, an important antioxidant [18]. In another study by Durhan et al, in which oral red ginseng was evaluated in experimental occlusive jaundice, it was observed that MDA value decreased and catalase value increased [17]. However, in the current study, MDA value decreased and catalase value increased, but no statistically significant difference was observed between the control and red ginseng groups.…”