Ratlarda Splenektomi Sonrası Red Ginsengin Lipit Profili, Endotel ve Oksidatif Hasar Üzerinde Koruyucu Etkisinin Değerlendirilmesi

Abstract

It was aimed to examine the effects of Red Ginseng (RG), which has anti-inflammatory and antioxidant properties, on the histopathological alterations and lipid metabolism following splenectomy. Methods: Rats were randomly divided into 3 groups of 10 rats each. Only laparotomy was conducted in group 1 (sham). In group 2 (control), splenectomy was performed but no therapy was offered. Splenectomy was performed and RG extract was supplied orogastrically at a dosage of 100mg/kg/day for 28 days in group 3 (RG group). At the end of the 28-day period, tissue samples were obtained for the assessment of histopathological alterations in the vascular, intestinal, and lung tissues, and blood samples were obtained for biochemical analysis. Results: The RG group had reduced significantly total cholesterol (TC), triglyceride (TG), and very low density lipoprotein (VLDL) levels than the control group (p<0.05). When mononuclear cell infiltration in colon and lung tissues was evaluated, it was shown to be considerably lower in the RG group (p<0.05). For aortic tissues, there was no difference between the groups. Malondialdehyde (MDA) levels were observed to be considerably lower in the RG group compared to the control group (p <0.05). The total sulfhydryl (t-SH) level increased considerably in the RG group as compared to the control group. (p<0.05) Conclusions: After splenectomy, RG usage decreases oxidative stress in mice. It has also been demonstrated to have a regulating impact on lipid metabolism. Furthermore, the administration of RG following splenectomy was found to have a poor likelihood of improving vascular, lung, and colon epithelial regeneration.