Does radiotherapy increase oxidative stress? A study with nasopharyngeal cancer patients revealing anomalies in isoprostanes measurements

Lim, Keith H.C.; Lee, Jetty Chung‐Yung; Earnest, Arul; Seet, Raymond C.S.; Halliwell, Barry

doi:10.3109/10715762.2010.499906

Cited by 14 publications

(5 citation statements)

References 20 publications

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“…Regarding the effect of head and neck radiotherapy on the levels of oxidative/nitrosative stress biomarkers, a study demonstrated that conventional radiotherapy in patients with nasopharyngeal cancer did not increase the urinary and plasma levels of F(2)‐isoprostane (a lipid peroxidation biomarker); on the contrary, the levels decreased . In another study , when patients with head and neck cancer were individualized to radiotherapy alone, no significant change was observed in mean values of plasma MDA levels between the pre‐ and post‐radiotherapy periods.…”

Section: Discussionmentioning

confidence: 99%

Effects of High‐Dose Cisplatin Chemotherapy and Conventional Radiotherapy on Urinary Oxidative and Nitrosative Stress Biomarkers in Patients with Head and Neck Cancer

Tuan

Visacri

Amaral

et al. 2015

Basic Clin Pharma Tox

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Cisplatin is a chemotherapeutic agent widely used in the treatment of several solid tumours. For patients with advanced head and neck squamous cell carcinoma in whom surgery is contraindicated, treatment with high-dose cisplatin administered every 21 days for 3 cycles concomitantly with conventional radiotherapy is recommended [1][2][3].Its anticancer mechanism is mediated by DNA binding, which leads to the formation of inter-and intrastrand crosslinks and results in defective DNA templates, arrest of DNA synthesis and replication, DNA damage and, finally, cell death [4]. In addition, cisplatin accumulates in human cells (normal and tumour cells) resulting in enhanced production of reactive oxygen species (ROS) and reactive nitrogen species (RNS), which leads to mitochondrial damage and dysfunction [5,6]. In addition, there is a decrease in the antioxidant defence system mediated primarily by links formed between cisplatin and glutathione, which culminates in the depletion of glutathione [7]. The excessive generation of ROS and RNS damages biomolecules, resulting in lipid, protein and DNA/RNA oxidation and causing toxicities including nephrotoxicity, neurotoxicity, ototoxicity and hepatotoxicity [8][9][10][11]. The intensity of biomolecular damage can be determined by oxidative/nitrosative stress biomarkers. In this study, we used malondialdehyde (MDA) and lipid hydroperoxides, which are indicators of lipid peroxidation/ oxidative stress biomarkers and nitrite, a nitrosative stress biomarker.Therefore, the aim of this study was to determine the effects of high-dose cisplatin chemotherapy and conventional radiotherapy on urinary levels of MDA, lipid hydroperoxides and nitrite biomarkers in patients with head and neck cancer. Material and MethodsThis was a prospective study conducted from January 2013 to November 2013 at the oncology clinic of a public teaching hospital in the state of São Paulo, Brazil. The research ethics committee of the institution approved the study, and all patients signed a consent form authorizing the use of their data.Patients and treatment characteristics. All patients were diagnosed with primary squamous cell carcinoma of the head and neck by a biopsy and were administered antineoplastic treatment with high-dose cisplatin (80 or 100 mg/m 2 ) with concomitant conventional radiotherapy as a therapeutic regimen. Patients who had undergone previous treatments for their tumours (surgery, chemotherapy and radiotherapy), or who refused to participate in the study, were excluded. Patients were dropped from the study if their treatment regimen changed before the study commenced, if they died or abandoned the treatment, or if complete oxidative stress data were not available (biomarkers or measurement times).The treatment regimen consisted of 3 cycles of chemotherapy with high-dose cisplatin (80 or 100 mg/m 2 ) on days 1, 22 and 43. Concomitantly with the chemotherapy, patients received a total dose of 70 Gy of radiation therapy divided into 35 daily applications of 2 Gy administered 5 days per w...

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Section: Discussionmentioning

confidence: 99%

Effects of High‐Dose Cisplatin Chemotherapy and Conventional Radiotherapy on Urinary Oxidative and Nitrosative Stress Biomarkers in Patients with Head and Neck Cancer

Tuan

Visacri

Amaral

et al. 2015

Basic Clin Pharma Tox

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“…This suggests that the systemic redox balance was maintained in these patients, despite the RT effects. These data, however, require a careful analysis because several studies suggest that radiation increases the oxidative stress in different tissues [11,12]. What it can be stated is that, at least in these patients, the local oxidative stress did not lead to a systemic redox imbalance that could be…”

Section: Systematics Of Data Collectionmentioning

confidence: 95%

Plasma antioxidant substances apparently do not influence the radiodermatitis occurrence

Munhoz

Viani

Soares

et al. 2020

Sci Med

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AIMS: Radiation affects not only tumors but also healthy tissues through the increment of oxidative stress. Thus, this study aimed to evaluate the oxidative stress degree as well as non-enzymatic antioxidant defenses in the plasma of patients submitted to radiotherapy and to verify if these parameters are modified in those patients who develop radiodermatitis.METHODS: Forty-one patients submitted to radiotherapy for treatment of breast cancer were followed. From these patients, plasma samples were obtained at the beginning, in the middle and at the end of the treatment, for analysis of thiobarbituric acid reactive substances (TBARS) and ferric reducing ability of plasma (FRAP).RESULTS: No significant differences were observed in terms of TBARS and FRAP in plasma harvested from these patients at the beginning and at the middle of the treatment. There was lower incidence of grade two radiodermatitis among patients undergoing radiotherapy with hypofractionated doses. There were no differences in FRAP or TBARS among patients who developed radiodermatitis of any degree in relation to those who did not develop this side effect. No differences of FRAP or TBARS were observed between patients that presented grade two radiodermatitis regarding to the others studied.CONCLUSION: There was no clear relationship between changes in TBARS or FRAP with the occurrence or severity of radiodermatitis.

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“…Cancer cells, compared to normal cells, [181,182] Isoprostanes Breast, nasopharynge [183,184] malondialdehyde (MDA) Colon, oral, breast [185][186][187] Lipid peroxidation 4-hydroxy-2, 3-nonenal (HNE) Liver, thyroid carcinoma [178,179] Protein oxidation carbonyl groups Colon [185] superoxide dismutase (SOD) Prostate [188] glutathione peroxidase 3 (GPX3) Breast, prostate [189,190] Expression levels /activity thioredoxin reductase-1 (TR1) Lung, prostate [191][192][193] are under increased oxidative stress associated with oncogenic transformation, alterations in metabolic activity, and increased generation of ROS [136]. The biological effects of ROS in cancer are multiple and non-linear.…”

Section: Targeting Ros As a Cancer Thera-peutic Strategymentioning

confidence: 99%

Tumor Invasion and Oxidative Stress: Biomarkers and Therapeutic Strategies

Muinelo‐Romay

Alonso-Alconada

Alonso-Nocelo

et al. 2012

CMM

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Tumor invasion is paradigmatic of the complex interactions connecting a carcinoma with its environment, and a reflex of the cellular and molecular heterogeneity that defines the initiation of dissemination and metastasis. The hostile situation generated by a growing carcinoma and a reactive stroma is at the basis of the promotion of carcinoma invasion and metastasis, with oxidative stress emerging as a main player in the acquisition of an aggressive tumor phenotype. In this review, we present this complex scenario with a focus on the contribution of the reactive environment and the oxidative stress to the cellular and molecular events associated with carcinoma invasion and metastasis. We also discuss the potential of oxidative stress as a source of biomarkers of advance disease, and as supplier of a therapeutic armamentarium against the initial steps of metastatic dissemination.

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Does radiotherapy increase oxidative stress? A study with nasopharyngeal cancer patients revealing anomalies in isoprostanes measurements

Cited by 14 publications

References 20 publications

Effects of High‐Dose Cisplatin Chemotherapy and Conventional Radiotherapy on Urinary Oxidative and Nitrosative Stress Biomarkers in Patients with Head and Neck Cancer

Effects of High‐Dose Cisplatin Chemotherapy and Conventional Radiotherapy on Urinary Oxidative and Nitrosative Stress Biomarkers in Patients with Head and Neck Cancer

Plasma antioxidant substances apparently do not influence the radiodermatitis occurrence

Tumor Invasion and Oxidative Stress: Biomarkers and Therapeutic Strategies

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