Tumor Invasion and Oxidative Stress: Biomarkers and Therapeutic Strategies

Muinelo‐Romay, Laura; Alonso-Alconada, Lorena; Alonso-Nocelo, Marta; Barbazán, Jorge; Abal, Miguel

doi:10.2174/156652412800792570

Cited by 7 publications

(5 citation statements)

References 174 publications

(192 reference statements)

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“…Numerous studies proved that increased oxidative stress would aggravate muscle fatigue [ 51 – 53 ]. Oxidative stress can be produced by tumors themselves [ 54 ] and directly or indirectly given rise by numerous chemotherapeutic agents [ 55 , 56 ]. In the oxidative stress state, overproduced free radicals like ROS will ultimately produce MDA, directly reflecting the degree of lipid peroxidation [ 57 ].…”

Section: Discussionmentioning

confidence: 99%

Yifei sanjie Pills Alleviate Chemotherapy-Related Fatigue by Reducing Skeletal Muscle Injury and Inhibiting Tumor Growth in Lung Cancer Mice

Chen

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Chemotherapy-related fatigue (CRF), one of the most severe adverse effects observed in cancer patients, has been theoretically related to oxidative stress, and antioxidant treatment might be one of the most valuable therapeutic approaches. However, there are still few effective pharmacological therapies. Yifei Sanjie pills (YFSJ), a classical formula used to treat lung cancer as complementary and alternative medicine, have been proved to alleviate CRF of lung cancer patients in clinical practices. However, the underlying mechanisms have not been clarified. In this study, our data showed that YFSJ alleviated CRF presented as reversing the decline of swimming time and locomotor activity induced by cisplatin (DDP). Moreover, YFSJ significantly reduces the accidence of mitophagy and mitochondrial damage and reduces apoptosis in skeletal muscle tissues caused by DDP. It probably works by decreasing the oxidative stress, inhibiting the activation of the AMPK/mTOR pathway, decreasing protein expression levels of Beclin1 and other autophagy-related proteins, and attenuating the activation of Cytochrome c (cyto. C), Cleaved Caspase-9 (c-Casp 9), and other apoptosis-related proteins. Furthermore, YFSJ enhanced DDP sensitivity by specifically promoting oxidative stress and activating apoptosis and autophagy in the tumor tissues of mice. It was also found that YFSJ reduced the loss of body weight caused by DDP, reversed the ascent of serum concentrations of alanine aminotransferase (ALT), aminotransferase (AST), and creatinine (CREA), increased the spleen index, and prolonged the survival time of mice. Taken together, these results revealed that YFSJ could alleviate CRF by reducing mitophagy and apoptosis induced by oxidative stress in skeletal muscle; these results also displayed the effects of YFSJ on enhancing chemotherapy sensitivity, improving quality of life, and prolonging survival time in lung cancer mice received DDP chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Yifei sanjie Pills Alleviate Chemotherapy-Related Fatigue by Reducing Skeletal Muscle Injury and Inhibiting Tumor Growth in Lung Cancer Mice

Chen

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Moreover, recent evidences showed that Aldo-keto reductases play an important role in inflammation by regulating oxidative stress-induced signals [57,58]. Oxidative stress is a fundamental source for the acquisition of a malignant phenotype, modulating the expression of other proteins such as metalloproteinases (MPPs) and activating the main pathways related to tumor development and dissemination [59,60]. 3D-CC IPA network (figure 4) was connected by a node of IL-1, whereas 3D-MC was characterized by a central node of Fibronectin (FN1), a mesenchymal marker related to invasiveness and migration [61], and maintained the expression of other acute-phase proteins such as A2M and ASHG, previously reported in secretome analysis [51,62].…”

Section: Discussionmentioning

confidence: 99%

Development and characterization of a three-dimensional co-culture model of tumor T cell infiltration

et al. 2016

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Tumor growth and metastasis entangle the alteration and recruitment of non-malignant cells to the primary tumor, among them immune cells, constituting the tumor microenvironment (TME). Communication between tumor cells and their stroma has been shown as a fundamental driving force of the tumoral process. A great deal of effort has been focused on depicting their specific interactions and crosstalk. However, most research has been carried out in 2D conventional cultures that alter cell morphology and intracellular signaling processes. Considering these premises, we have developed a 3D cell co-culture model to mimic T cell infiltration into the tumor mass and explore tumor-immune cells interactions in the TME. Expression of specific cell markers and assessment of cell proliferation were carried out to characterize the proposed 3D co-culture model. Additionally, the study and profiling of the secretome revealed a subset of particular cancer-related inflammation proteins prompted upon 3D cultivation of tumor cells in presence of lymphocytes, pointing out an intercellular communication. Altogether, these results suggest that our 3D cell co-culture model can be a useful tool to identify and study critical factors mediating the crosstalk between tumor and immune cells in the TME. Finally, the potential of this model as a drug-screening platform has been explored using docetaxel as a model antitumoral compound.

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“…Growing evidence indicates that exposure of elevated oxidants is known to cause muscle weakness and accelerate the development of fatigue [ 37 – 39 ]. Except for being produced by tumors themselves [ 40 ], the oxidative stress state is always directly or indirectly produced by numerous chemotherapeutic agents. Some chemotherapeutic agents that include a quinone moiety in their chemical structure can directly produce a state of oxidative stress by interacting with molecular oxygen and undergoing redox cycling, leading to the generation of reactive oxygen species (ROS) [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Bu-Zhong-Yi-Qi pill alleviate the chemotherapy-related fatigue in 4 T1 murine breast cancer model

Ouyang

Liu

Tan

et al. 2014

BMC Complement Altern Med

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BackgroundPaclitaxel induced fatigue still remains underrecognized and undertreated, partly because of limited understanding of its pathophysiology and lack of effective treatments. This study is aim to evaluate the anti-fatigue effects and mechanism of Bu-Zhong-Yi-Qi pill in murine 4 T1 breast cancer mice were treated with paclitaxel.MethodsBreast cancer mice established with murine 4 T1 cells were randomly and repectively divided into five groups: negative control group (NC), tumor control group (TC), paclitaxel group (PTX), Bu-Zhong-Yi-Qi pill group (BZYQ) and Bu-Zhong-Yi-Qi pill plus paclitaxel group (BZYQ + PTX). The mice were administered for 21 days. During this period, the tumor volume, body weight and the weight-loaded swimming time were measured. After the last administration, all mice were sacrificed, weighted the tumor, measured immune cell cytokines and oxidative stress indicator. The remaining 10 mice in each group were observed for survival analysis.ResultsTreatments with BZYQ + PTX and PTX significantly reduced the rates of tumor volume in comparison with TC starting on the 9th day and the 18th day respectively (P < 0.05-0.01), and presented decreased tumor weight compared to TC (P < 0.05-0.01). Compared with mice in TC group, the median survival time and the average survival time in BZYQ + PTX group, BZYQ group and PTX group were significantly prolonged (P < 0.05-0.01). The swimming time of the BZYQ + PTX group gradually increased, which is longer than the PTX group on Day 14 and Day 21 (P < 0.01). The level of TNF-α was lower in BZYQ + PTX group than PTX group (P < 0.01). The level of SOD activity in BZYQ + PTX group was lower than the NC group (P <0.01), but much higher than the PTX group (P < 0.01). The level of MDA of BZYQ + PTX group was higher than the NC group (P < 0.01), but significant lower than the PTX group (P < 0.01).ConclusionsBZYQ has the potential of alleviating paclitaxel chemotherapy-related fatigue in 4 T1 breast cancer mice by reducing the serum levels of TNF-α and modulating the level of MDA and the SOD activity.

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Tumor Invasion and Oxidative Stress: Biomarkers and Therapeutic Strategies

Cited by 7 publications

References 174 publications

Yifei sanjie Pills Alleviate Chemotherapy-Related Fatigue by Reducing Skeletal Muscle Injury and Inhibiting Tumor Growth in Lung Cancer Mice

Yifei sanjie Pills Alleviate Chemotherapy-Related Fatigue by Reducing Skeletal Muscle Injury and Inhibiting Tumor Growth in Lung Cancer Mice

Development and characterization of a three-dimensional co-culture model of tumor T cell infiltration

Bu-Zhong-Yi-Qi pill alleviate the chemotherapy-related fatigue in 4 T1 murine breast cancer model

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