Does Preoperative Electrical Stimulation of the Skin Alter the Healing Process?

Borba, Graziela C.; Hochman, Bernardo; Liebano, Richard Eloin; Enokihara, Mílvia M. S. S.; Ferreira, Lydia Masako

doi:10.1016/j.jss.2009.08.018

Cited by 23 publications

(28 citation statements)

References 26 publications

(25 reference statements)

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“…During inflammation, ES induces a faster inflammatory response39 and an increased vascular vasodilatation73 that increases tissue oxygenation,37 blood flow,37,58,59,69 and skin temperature 59. During the proliferation phase, ES generates increased angiogenesis,30,36,57,59 collagen matrix formation,36–38 wound contraction,29,57 and reepithelialization 57,60. Finally, during the remodeling phase, increased cellular activity produces an advanced remodeling57 at a systemic level.…”

Section: Effects Of Exogenous Electric Current On Wound Healingmentioning

confidence: 99%

“…Thus, spatiotemporal control of EST to enhance angiogenesis is crucial. Several studies on animal models and clinical trials have shown that ES increases the level of VEGF and the number of blood vessels in the wound 30,58,59,66,73. Higher levels of VEGF linked to enhancing angiogenesis and advanced healing have been reported in the stimulated arm of each patient.…”

Section: Angiogenesis: Friend or Foe?mentioning

confidence: 99%

See 1 more Smart Citation

A current affair: electrotherapy in wound healing

Hunckler¹,

Mel²

2017

JMDH

111

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New developments in accelerating wound healing can have immense beneficial socioeconomic impact. The wound healing process is a highly orchestrated series of mechanisms where a multitude of cells and biological cascades are involved. The skin battery and current of injury mechanisms have become topics of interest for their influence in chronic wounds. Electrostimulation therapy of wounds has shown to be a promising treatment option with no-device-related adverse effects. This review presents an overview of the understanding and use of applied electrical current in various aspects of wound healing. Rapid clinical translation of the evolving understanding of biomolecular mechanisms underlying the effects of electrical simulation on wound healing would positively impact upon enhancing patient’s quality of life.

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Section: Effects Of Exogenous Electric Current On Wound Healingmentioning

confidence: 99%

Section: Angiogenesis: Friend or Foe?mentioning

confidence: 99%

A current affair: electrotherapy in wound healing

Hunckler¹,

Mel²

2017

JMDH

111

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“…An externally applied electric field can then result in an electric current being driven along the wound surface, enhancing the endogenous electric field and arguably augmenting the healing processes [5], [6], [7], [8], [9], [10], [11], [12]. Electric fields have been reported to direct cell migration in many different cell types [11], [13], [14], activate signaling pathways such as cdc42p, Rho/Rac, PI3K/PTEN and phosphatidylinositol (PIP) [11], [15], [16], [17], activation of epithelial sodium channels [18], cellular electrotaxis of macrophages [19], [20], neutrophils [19], [21] and fibroblasts [22], [23], [24], [25], increase production of ATP and DNA [19], [26], [27], [28], increase collagen secretion by fibroblasts [22], [29] and increase blood flow and capillary density [30], [31], [32]. Although there are some outcome-based and mechanistic evidence supporting electrical stimulation (ES) promoting wound healing [11], a better understanding is lacking because of limitation in standardized procedure of application of ES to wounds.…”

Section: Introductionmentioning

confidence: 99%

Improvement of Human Keratinocyte Migration by a Redox Active Bioelectric Dressing

et al. 2014

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Exogenous application of an electric field can direct cell migration and improve wound healing; however clinical application of the therapy remains elusive due to lack of a suitable device and hence, limitations in understanding the molecular mechanisms. Here we report on a novel FDA approved redox-active Ag/Zn bioelectric dressing (BED) which generates electric fields. To develop a mechanistic understanding of how the BED may potentially influence wound re-epithelialization, we direct emphasis on understanding the influence of BED on human keratinocyte cell migration. Mapping of the electrical field generated by BED led to the observation that BED increases keratinocyte migration by three mechanisms: (i) generating hydrogen peroxide, known to be a potent driver of redox signaling, (ii) phosphorylation of redox-sensitive IGF1R directly implicated in cell migration, and (iii) reduction of protein thiols and increase in integrinαv expression, both of which are known to be drivers of cell migration. BED also increased keratinocyte mitochondrial membrane potential consistent with its ability to fuel an energy demanding migration process. Electric fields generated by a Ag/Zn BED can cross-talk with keratinocytes via redox-dependent processes improving keratinocyte migration, a critical event in wound re-epithelialization.

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“…Electrical stimulation (ES) activates the production of ATP and DNA, 4,11 makes fibroblasts generate more collagen, 7,12,13 and increases blood flow and capillary density. [14][15][16] …”

Section: Translational Relevancementioning

confidence: 99%

“…14,32,33 Mehmandoust et al 32 (2007) investigated the effects of anodal and cathodal ES on acute wound healing. In an RCT 42 male albino guinea pigs were divided into two control groups (C1 and C2) and four experimental groups (E1-E4).…”

Section: 3mentioning

confidence: 99%