Does Mycoplasma sp. play role in small cell lung cancer?

Pehlıvan, Mustafa; Itirli, Gulcin; Önay, Hüseyin; Bulut, Haydar; Koyuncuoğlu, Meral; Pehlıvan, Sacide

doi:10.1016/j.lungcan.2004.01.007

Cited by 24 publications

(21 citation statements)

References 8 publications

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“…First, they may give novel clues to why certain infections; for example, Mycoplasma might promote cancer progression (47). Mycoplasma infections have been detected in various cancers, including breast cancer (48,49). After having been taken up by the cells, Mycoplasma bacteria have been detected in the same subcellular localization, the lysosome, where also activated TLR9 is localized (21,50).…”

Section: Discussionmentioning

confidence: 99%

Toll-Like Receptor 9 Agonists Promote Cellular Invasion by Increasing Matrix Metalloproteinase Activity

Merrell¹,

Ilvesaro²,

Lehtonen

et al. 2006

Molecular Cancer Research

212

255

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Toll-like receptor 9 (TLR9) recognizes microbial DNA. We show here that TLR9 protein is expressed in human breast cancer cells and clinical breast cancer samples. Stimulation of TLR9-expressing breast cancer cells with the TLR9 agonistic CpG oligonucleotides (1-10 Mmol/L) dramatically increased their in vitro invasion in both Matrigel assays and three-dimensional collagen cultures. Similar effects on invasion were seen in TLR9-expressing astrocytoma and glioblastoma cells and in the immortalized human breast epithelial cell line MCF-10A. This effect was not, however, dependent on the CpG content of the TLR9 ligands because the non-CpG oligonucleotides induced invasion of TLR9-expressing cells. CpG or non-CpG oligonucleotide-induced invasion in MDA-MB-231 cells was blunted by chloroquine and they did not induce invasion of TLR9 À breast cancer cells.Treatment of MDA-MB-231 cells with CpG or non-CpG oligonucleotides induced the formation of f50-kDa gelatinolytic band in zymograms. This band and the increased invasion were abolished by a matrix metalloproteinase (MMP) inhibitor GM6001 but not by a serine proteinase inhibitor aprotinin. Furthermore, CpG oligonucleotide treatment decreased tissue inhibitor of metalloproteinase-3 expression and increased levels of active MMP-13 in TLR9-expressing but not TLR9 À breast cancer cells without affecting MMP-8. Neutralizing anti-MMP-13 antibodies inhibited the CpG oligonucleotide-induced invasion. These findings suggest that infections may promote cancer progression through a novel TLR9-mediated mechanism. They also propose a new molecular target for cancer therapy, because TLR9 has not been associated with cancer invasiveness previously.

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Section: Discussionmentioning

confidence: 99%

Toll-Like Receptor 9 Agonists Promote Cellular Invasion by Increasing Matrix Metalloproteinase Activity

Merrell¹,

Ilvesaro²,

Lehtonen

et al. 2006

Molecular Cancer Research

212

255

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“…In tissue specimens from actual patients, mycoplasmas are found in precancerous lesions as well as in malignant tissues, such as those from stomach, colon, ovarian, and lung cancers (43,112,129,142,191). The prevalence of mycoplasma infection is significantly higher in stomach and colon cancer tissues than in their respective precancerous lesions (112).…”

Section: Oncoproteins and Cell Transformationmentioning

confidence: 99%

Role of Bacteria in Oncogenesis

2010

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SUMMARY Although scientific knowledge in viral oncology has exploded in the 20th century, the role of bacteria as mediators of oncogenesis has been less well elucidated. Understanding bacterial carcinogenesis has become increasingly important as a possible means of cancer prevention. This review summarizes clinical, epidemiological, and experimental evidence as well as possible mechanisms of bacterial induction of or protection from malignancy.

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“…Nonetheless, Chlamydia sp. and Mycoplasma pneumoniae can cause chronic pulmonary diseases such as chronic bronchitis and adult-onset asthma (Bjornsson et al, 1996;Daian et al, 2000), and chronic infection with C. pneumoniae or M. pneumoniae has been linked to an increased risk of lung cancer (Pehlivan et al, 2004;Littman et al, 2005). C. pneumoniae and C. trachomatis infections, particularly the former, are also associated with an increased risk of lymphoma although their specific association with pulmonary MALT lymphoma is unclear (Anttila et al, 1998).…”

mentioning

confidence: 99%

Chlamydiae and Mycoplasma infections in pulmonary MALT lymphoma

Chanudet

Adam

et al. 2007

Br J Cancer

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Chlamydia pneumoniae, Chlamydia trachomatis and Chlamydia psittaci were detected at low frequencies (o20%) among 69 pulmonary mucosa-associated lymphoid tissue (MALT) lymphomas, 30 other lymphoproliferative disorders (LPD) and 44 non-LPD. The incidence of individual Chlamydiae was generally higher in MALT lymphoma than non-LPD, although not reaching statistical significance. Mycoplasma pneumoniae DNA was not detected.

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Does Mycoplasma sp. play role in small cell lung cancer?

Cited by 24 publications

References 8 publications

Toll-Like Receptor 9 Agonists Promote Cellular Invasion by Increasing Matrix Metalloproteinase Activity

Toll-Like Receptor 9 Agonists Promote Cellular Invasion by Increasing Matrix Metalloproteinase Activity

Role of Bacteria in Oncogenesis

Chlamydiae and Mycoplasma infections in pulmonary MALT lymphoma

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