Role of Bacteria in Oncogenesis

Chang, Alicia; Parsonnet, Julie

doi:10.1128/cmr.00012-10

Cited by 160 publications

(147 citation statements)

References 272 publications

(286 reference statements)

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“…Several studies have associated the oral microbiota with head and neck malignancies, although no direct causal association between specific bacteria or mechanisms have been demonstrated (10,28,48). Therefore, in addition to E. faecalis, we included three oral streptococci previously associated with OSCC, i.e., S. anginosus, S. salivarius, and S. mitis (50), in our analysis of H 2 O 2 production.…”

Section: Discussionmentioning

confidence: 99%

Enterococcus faecalis Enhances Cell Proliferation through Hydrogen Peroxide-Mediated Epidermal Growth Factor Receptor Activation

et al. 2012

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f Enterococcus faecalis is a member of the intestinal and oral microbiota that may affect the etiology of colorectal and oral cancers. The mechanisms by which E. faecalis may contribute to the initiation and progression of these cancers remain uncertain. Epidermal growth factor receptor (EGFR) signaling is postulated to play a crucial role in oral carcinogenesis. A link between E. faecalis and EGFR signaling in oral cancer has not been elucidated. The present study aimed to evaluate the association between E. faecalis and oral cancer and to determine the underlying mechanisms that link E. faecalis to EGFR signaling. We report the high frequency of E. faecalis infection in oral tumors and the clinical association with EGFR activation. Using human oral cancer cells, we support the clinical findings and demonstrate that E. faecalis can induce EGFR activation and cell proliferation. E. faecalis activates EGFR through production of H 2 O 2 , a signaling molecule that activates several signaling pathways. Inhibitors of H 2 O 2 (catalase) and EGFR (gefitinib) significantly blocked E. faecalis-induced EGFR activation and cell proliferation. Therefore, E. faecalis infection of oral tumor tissues suggests a possible association between E. faecalis infection and oral carcinogenesis. Interaction of E. faecalis with host cells and production of H 2 O 2 increase EGFR activation, thereby contributing to cell proliferation.

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Section: Discussionmentioning

confidence: 99%

Enterococcus faecalis Enhances Cell Proliferation through Hydrogen Peroxide-Mediated Epidermal Growth Factor Receptor Activation

et al. 2012

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“…In response to the overwhelming evidence linking H. pylori infection to human cancer, the International Agency for Research on Cancer listed H. pylori as a definite human oncogenic agent in 1994 [36,[73][74][75]. Therefore, we were interested in finding out the MIC of AgNPs against both pylori and non-pylori strains, such as H. pylori and H. felis, respectively.…”

Section: Determination Of Mic Of Agnps Against H Pylori and H Felismentioning

confidence: 99%

Multidimensional effects of biologically synthesized silver nanoparticles in Helicobacter pylori, Helicobacter felis, and human lung (L132) and lung carcinoma A549 cells

Gurunathan¹,

Jeong²,

Han³

et al. 2016

Nano Online

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Silver nanoparticles (AgNPs) are prominent group of nanomaterials and are recognized for their diverse applications in various health sectors. This study aimed to synthesize the AgNPs using the leaf extract of Artemisia princeps as a bio-reductant. Furthermore, we evaluated the multidimensional effect of the biologically synthesized AgNPs in Helicobacter pylori , Helicobacter felis , and human lung (L132) and lung carcinoma (A549) cells. UV-visible (UV-vis) spectroscopy confirmed the synthesis of AgNPs. X-ray diffraction (XRD) indicated that the AgNPs are specifically indexed to a crystal structure. The results from Fourier transform infrared spectroscopy (FTIR) indicate that biomolecules are involved in the synthesis and stabilization of AgNPs. Dynamic light scattering (DLS) studies showed the average size distribution of the particle between 10 and 40 nm, and transmission electron microscopy (TEM) confirmed that the AgNPs were significantly well separated and spherical with an average size of 20 nm. AgNPs caused dose-dependent decrease in cell viability and biofilm formation and increase in reactive oxygen species (ROS) generation and DNA fragmentation in H. pylori and H. felis. Furthermore, AgNPs induced mitochondrial-mediated apoptosis in A549 cells; conversely, AgNPs had no significant effects on L132 cells. The results from this study suggest that AgNPs could cause cell-specific apoptosis in mammalian cells. Our findings demonstrate that this environmentally friendly method for the synthesis of AgNPs and that the prepared AgNPs have multidimensional effects such as anti-bacterial and anti-biofilm activity against H. pylori and H. felis and also cytotoxic effects against human cancer cells. This report describes comprehensively the effects of AgNPs on bacteria and mammalian cells. We believe that biologically synthesized AgNPs will open a new avenue towards various biotechnological and biomedical applications in the near future.

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“…Silverman [4,18,19]. Such studies fall into two categories: global analyses using broad/multiple detection methods to assess the prevalence of numerous species and studies that seek to specifically identify a single pathogen (or a limited number of species …”

Section: Translational Biomedicine Issn 2172-0479mentioning

confidence: 99%

The Carcinogenic Potential of Microbial Infections of the Prostate and the Role of Contaminations

Sayanjali¹

2018

Transl Biomed

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Several studies have identified bacteria and viruses in human prostatic tissues. The tumor microenvironment of prostate carcinoma is a complex community of genetically transformed cancer cells, non-neoplastic cells, and a diverse collection of microorganisms. Each of these components may contribute to carcinogenesis; however, the role of the microbes is the least well known. A variety of detection techniques have been used, such as PCR-based approaches, fluorescence insitu hybridization, immunological detection assays, and (bacterial) cultivation. Detection rates vary between these methods and each method has specific advantages and limitations. However, confounded by the high risk of contamination during or after the biopsy, it is challenging to make solid conclusions about the presence of certain microorganisms and its possible role in disease formation or progression. This doubt increases with the sensitive detection methods such as next generation sequencing technologies if there are no proper controls. Resident microbial communities often differ between healthy and diseased states, but whether these differences are of primary etiological importance or secondary to the altered inflammatory environment remains largely unknown. Key MessageThere have been studies showing the presence of the microbial infections in the prostate, but due to lack of proper controls and the risk of contaminations, a solid conclusion cannot be made.

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Role of Bacteria in Oncogenesis

Cited by 160 publications

References 272 publications

Enterococcus faecalis Enhances Cell Proliferation through Hydrogen Peroxide-Mediated Epidermal Growth Factor Receptor Activation

Enterococcus faecalis Enhances Cell Proliferation through Hydrogen Peroxide-Mediated Epidermal Growth Factor Receptor Activation

Multidimensional effects of biologically synthesized silver nanoparticles in Helicobacter pylori, Helicobacter felis, and human lung (L132) and lung carcinoma A549 cells

The Carcinogenic Potential of Microbial Infections of the Prostate and the Role of Contaminations

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