Does metformin affect mammographic breast density in postmenopausal women with type 2 diabetes

Öztürk, Mehmet Akif; Öztürk, Serpil; Eryılmaz, Müzeyyen; Cinar, Selin; Sertbaş, Meltem; Ak, Feyza; Sertbaş, Yaşar; Özdemir, Ali

doi:10.1080/09513590.2020.1725972

Cited by 3 publications

(3 citation statements)

References 10 publications

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“…31 However, some studies demonstrated that metformin has no significant effect on the breast density in postmenopausal patients with type 2 diabetes. 32 It has also been reported that the use of metformin in diabetic patients is associated with decreased breast density, but this correlation disappears after adjusting for body weight. 33 Therefore, whether metformin improves women’s breast cancer risk by reducing the breast density is unclear, and no study investigated the breast density reduction effect of metformin in overweight/obese premenopausal women without diabetes.…”

Section: Discussionmentioning

confidence: 98%

“…One study indicated that metformin intervention has no significant effect on the breast density in postmenopausal women with diabetes. 32 Our target population was premenopausal women without diabetes, and a lifestyle intervention was carried out. On the one hand, the breast density in premenopausal women is higher than that in postmenopausal women; therefore, the improvement in the difference may be more obvious.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Metformin on Breast Density in Overweight/Obese Premenopausal Women

Leng

Jiang

et al. 2021

DMSO

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Effect of Metformin on Breast Density in Overweight/Obese Premenopausal Women

Leng

Jiang

et al. 2021

DMSO

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“… 72 , 73 In 2 small observational studies of postmenopausal women with type 2 diabetes, an inverse relationship was identified between the use of metformin and MBD, but the relationship was not statistically significant. 74 , 75 Use of fertility drugs and statins was reviewed and not shown to be associated with significant changes in MBD. 76-78 …”

Section: Influence Of Medications On Mbdmentioning

confidence: 99%

Association Between Lifestyle Changes, Mammographic Breast Density, and Breast Cancer

2022

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In screening for breast cancer (BC), mammographic breast density (MBD) is a powerful risk factor that increases breast carcinogenesis and synergistically reduces the sensitivity of mammography. It also reduces specificity of lesion identification, leading to recalls, additional testing, and delayed and later-stage diagnoses, which result in increased health care costs. These findings provide the foundation for dense breast notification laws and lead to the increase in patient and provider interest in MBD. However, unlike other risk factors for BC, MBD is dynamic through a woman’s lifetime and is modifiable. Although MBD is known to change as a result of factors such as reproductive history and hormonal status, few conclusions have been reached for lifestyle factors such as alcohol, diet, physical activity, smoking, body mass index (BMI), and some commonly used medications. Our review examines the emerging evidence for the association of modifiable factors on MBD and the influence of MBD on BC risk. There are clear associations between alcohol use and menopausal hormone therapy and increased MBD. Physical activity and the Mediterranean diet lower the risk of BC without significant effect on MBD. Although high BMI and smoking are known risk factors for BC, they have been found to decrease MBD. The influence of several other factors, including caffeine intake, nonhormonal medications, and vitamins, on MBD is unclear. We recommend counseling patients on these modifiable risk factors and using this knowledge to help with informed decision making for tailored BC prevention strategies.

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Breast Density: Current Knowledge, Assessment Methods, and Clinical Implications

Chalfant

Hoyt

2022

Journal of Breast Imaging

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Breast density is an accepted independent risk factor for the future development of breast cancer, and greater breast density has the potential to mask malignancies on mammography, thus lowering the sensitivity of screening mammography. The risk associated with dense breast tissue has been shown to be modifiable with changes in breast density. Numerous studies have sought to identify factors that influence breast density, including age, genetic, racial/ethnic, prepubertal, adolescent, lifestyle, environmental, hormonal, and reproductive history factors. Qualitative, semiquantitative, and quantitative methods of breast density assessment have been developed, but to date there is no consensus assessment method or reference standard for breast density. Breast density has been incorporated into breast cancer risk models, and there is growing consciousness of the clinical implications of dense breast tissue in both the medical community and public arena. Efforts to improve breast cancer screening sensitivity for women with dense breasts have led to increased attention to supplemental screening methods in recent years, prompting the American College of Radiology to publish Appropriateness Criteria for supplemental screening based on breast density.

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Does metformin affect mammographic breast density in postmenopausal women with type 2 diabetes

Cited by 3 publications

References 10 publications

Effect of Metformin on Breast Density in Overweight/Obese Premenopausal Women

Effect of Metformin on Breast Density in Overweight/Obese Premenopausal Women

Association Between Lifestyle Changes, Mammographic Breast Density, and Breast Cancer

Breast Density: Current Knowledge, Assessment Methods, and Clinical Implications

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