Effect of Metformin on Breast Density in Overweight/Obese Premenopausal Women

Leng, Weiling; Pu, Danlan; Jiang, Juan; Lei, Xiaotian; Wu, Qinan; Chen, Bing

doi:10.2147/dmso.s330625

Cited by 6 publications

(13 citation statements)

References 49 publications

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“…On the other hand, the addition of the biguanide metformin to sustained dietary and exercise interventions for 1 year in women without signs of breast cancer has resulted in improved BMI, adiponectin levels, and patients’ Breast Imaging Reporting and Data System scores. The addition of metformin was also associated with decreased positive pathological biopsy rate 87 . Thus, presurgical weight loss counseling, dietary modification, and additional interventions demonstrate mixed pro‐ and antitumorigenic effects 86,87 …”

Section: Methodsmentioning

confidence: 97%

“… 87 Thus, presurgical weight loss counseling, dietary modification, and additional interventions demonstrate mixed pro‐ and antitumorigenic effects. 86 , 87 …”

Section: Methodsmentioning

confidence: 99%

“…The addition of metformin was also associated with decreased positive pathological biopsy rate. 87 Thus, presurgical weight loss counseling, dietary modification, and additional interventions demonstrate mixed pro-and antitumorigenic effects. 86,87 In contrast, the impact of exercise and weight loss on breast cancer survivors appears to be less ambiguous.…”

Section: The Impact Of Diet and Exercise On Breast Cancermentioning

confidence: 99%

“…87 Thus, presurgical weight loss counseling, dietary modification, and additional interventions demonstrate mixed pro-and antitumorigenic effects. 86,87 In contrast, the impact of exercise and weight loss on breast cancer survivors appears to be less ambiguous. Several supervised exercise programs have demonstrated decreased expression of proinflammatory adipokines and insulin resistance as a result of intervention as well as enhanced expression of anti-inflammatory markers, such as adiponectin in survivors of breast cancer who are exposed to supervised weight loss management (Table 1).…”

Section: The Impact Of Diet and Exercise On Breast Cancermentioning

confidence: 99%

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The impact of obesity and adipokines on breast and gynecologic malignancies

Tewari

Vargas

Reizes

2022

Annals of the New York Academy of Sciences

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The link between obesity and multiple disease comorbidities is well established. In 2003, Calle and colleagues presented the relationship between obesity and several cancer types, including breast, ovarian, and endometrial malignancies. Nearly, 20% of cancer‐related deaths in females can be accounted for by obesity. Identifying obesity as a risk factor for cancer led to a focus on the role of fat‐secreted cytokines, known as adipokines, on carcinogenesis and tumor progression. Early studies indicated that the adipokine leptin increases cell proliferation, invasion, and inhibition of apoptosis in multiple cancer types. As a greater appreciation of the obesity–cancer link has amassed, we now know that additional adipokines can impact tumorigenesis. A deeper understanding of the adipokine‐activated signaling in cancer may identify new treatment strategies irrespective of obesity. Moreover, adipokines may serve as disease biomarkers, harnessing the potential of obesity‐associated factors to serve as indicators of treatment response and disease prognosis. As studies investigating obesity and women's cancers continue to expand, it has become evident that breast, ovarian, and uterine cancers are distinctly impacted by adipokines. While complex, these distinct interactions may provide insight into cancer progression in these organs and new opportunities for targeted therapies. This review aims to organize and present the literature from the last 5 years investigating the mechanisms and implications of adipokine signaling in breast, endometrial, and ovarian cancers with a special focus on leptin and adiponectin.

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Section: Methodsmentioning

confidence: 97%

“… 87 Thus, presurgical weight loss counseling, dietary modification, and additional interventions demonstrate mixed pro‐ and antitumorigenic effects. 86 , 87 …”

Section: Methodsmentioning

confidence: 99%

Section: The Impact Of Diet and Exercise On Breast Cancermentioning

confidence: 99%

Section: The Impact Of Diet and Exercise On Breast Cancermentioning

confidence: 99%

See 2 more Smart Citations

The impact of obesity and adipokines on breast and gynecologic malignancies

Tewari

Vargas

Reizes

2022

Annals of the New York Academy of Sciences

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“…Interestingly, metformin has gained huge attention in cancer treatment, especially in breast cancer, and its potential anti-tumorigenic effect was shown to be mediated through the regulation of several pathways that include the potentiation of adiponectin [ 135 ]. In a recent study, Leng et al demonstrated that metformin significantly increases serum adiponectin levels in overweight/obese pre-menopausal women [ 136 ]. A huge number of preclinical studies and more than 50 ongoing and completed clinical trials suggested the repurposing of this well-tolerated, cost-effective drug to be used in early and advanced breast cancer patients, and approval is eagerly awaited [ 137 ].…”

Section: Reactivation Of Adiponectin Pathways In Breast Cancer Modelsmentioning

confidence: 99%

Targeting Adiponectin in Breast Cancer

et al. 2022

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Obesity and breast cancer are two major health issues that could be categorized as sincere threats to human health. In the last few decades, the relationship between obesity and cancer has been well established and extensively investigated. There is strong evidence that overweight and obesity increase the risk of postmenopausal breast cancer, and adipokines are the central players in this relationship. Produced and secreted predominantly by white adipose tissue, adiponectin is a bioactive molecule that exhibits numerous protective effects and is considered the guardian angel of adipokine. In the obesity–cancer relationship, more and more evidence shows that adiponectin may prevent and protect individuals from developing breast cancer. Recently, several updates have been published on the implication of adiponectin in regulating tumor development, progression, and metastases. In this review, we provide an updated overview of the metabolic signaling linking adiponectin and breast cancer in all its stages. On the other hand, we critically summarize all the available promising candidates that may reactivate these pathways mainly by targeting adiponectin receptors. These molecules could be synthetic small molecules or plant-based proteins. Interestingly, the advances in genomics have made it possible to create peptide sequences that could specifically replace human adiponectin, activate its receptor, and mimic its function. Thus, the obvious anti-cancer activity of adiponectin on breast cancer should be better exploited, and adiponectin must be regarded as a serious biomarker that should be targeted in order to confront this threatening disease.

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