Does JC virus have a role in the etiology and prognosis of Egyptian colorectal carcinoma?

Samaka, Rehab Monir; El-Wahed, Moshira M. Abd; Aiad, Hayam A; Kandil, Mohamed; Al-Sharaky, Dalia Rifaat

doi:10.1111/apm.12001

Cited by 14 publications

(12 citation statements)

References 34 publications

(67 reference statements)

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“…Sarvari et al, 2018;Haghi Navand et al, 2019) and five studies assessed the BK virus prevalence (Casini et al, 2005;Giuliani et al, 2008;Tseng et al, 2014;Jarzynski et al, 2017;Sarvari et al, 2018) Some studies had used several targets and diagnostic methods (Enam et al, 2002;Hori et al, 2005;Lin et al, 2008;Tsekov et al, 2011;Mou et al, 2012;Matalka et al, 2013;Tseng et al, 2014). One stydy used In Situ Hybridization (ISH) (Samaka et al, 2013), one study used real time PCR(Polymerase Chain Reaction) (Tsekov et al, 2011) and others used PCR, nested-PCR or Immunohistochemistry (IHC), (Enam et al, 2002;Casini et al, 2005;Hori et al, 2005;Theodoropoulos et al, 2005;Goel et al, 2006;Giuliani et al, 2008;Jung et al, 2008;Lin et al, 2008;Niv et al, 2010a;Niv et al, 2010b;Ramamoorthy et al, 2011;Tsekov et al, 2011;Mou et al, 2012;Coelho et al, 2013;Matalka et al, 2013;Ripple et al, 2014;Sinagra et al, 2014;Ksiaa et al, 2015;Jarzynski et al, 2017;Toumi et al, 2017;Sarvari et al, 2018;Haghi Navand et al, 2019). Most of the studies targeted DNA and T antigen (TAg) from the samples in order to diagnose the viruses …”

Section: Discussionmentioning

confidence: 99%

Prevalence of JC and BK viruses in Patients with Colorectal Cancer: A Systematic Review and Meta- Analysis

Shoraka

Abobakri

Tahami

et al. 2020

Asian Pac J Cancer Prev

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Introduction: Polyomaviruses including BK virus (BKV) and JC virus (JCV) are widespread in human and have been associated with colorectal cancer (CRC) in some studies. The aim of present systematic review and meta-analysis article is to calculate the pooled prevalence of BKV and JCV in patients with CRC and assessing their association with this malignancy. Materials and Methods: Domestic databases and Sciences Direct, PubMed, ProQuest, Web of Sciences and Scopus were searched for relevant articles up to 2nd June 2019Two independent reviewers extracted the related data from eligible articles. The pooled prevalence and pooled odds ratio (POR) and their 95% confidence interval (95% CI) were calculated using “metaprop” and “metan” commands in Stata 14. Where I2 statistics were >50%, the random effect model was used. Results: From 1461 relevant studies, 24 articles were eligible and included in the qualitative while 19 articles included in quantitative analysis. The pooled prevalence based on diagnostic methods varies from 29% using immunohistochemistry to 52% using nested-PCR method. The likelihood of being infected with JCV was significantly higher in CRC patients compared to healthy (POR: 4.41, 95% CI: 2.13 – 9.13) controls, normal adjacent mucosa (POR: 2.79, 95% CI: 1.3-5.9) and colorectal adenoma (POR: 3.1, 95% CI: 1.5-6.5) but was not significant when non-CRC patients used as control group. Conclusion: The prevalence of JCV in colorectal patients was substantially variable by different methods and targets. The significant association between JCV and CRC that was observed in the present study is not indicative of causation and should be studied more in large-scale prospective designs.

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Section: Discussionmentioning

confidence: 99%

Prevalence of JC and BK viruses in Patients with Colorectal Cancer: A Systematic Review and Meta- Analysis

Shoraka

Abobakri

Tahami

et al. 2020

Asian Pac J Cancer Prev

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“…Additionally 240 adenoma tissues were analyzed and compared with 257 normal tissues from healthy controls: JCPyV DNA was found in 77 adenoma (32.1%) and 48 normal (18.7%) tissues, respectively (Table 2 ) [ 115 , 127 , 128 ]. The expression of the JCPyV proteins was analyzed only in 4 studies [ 126 , 130 – 132 ] and it has been observed that the early T-Ag protein was present in 9 out of 172 (5.2%) colorectal cancer or adenoma tissues and in 7 out of 38 (18.4%) adjacent noncancerous tissues or normal tissues from healthy controls (Table 3 ). Rollison and colleagues and Lundstig and colleagues collected blood samples from colorectal patients, and healthy controls and found a total of 210 (41.3%), and 179 (38.4%) seropositive subjects out of 509 colorectal patients, and 466 and healthy subjects (Table 3 ) [ 130 , 131 ].…”

Section: Jcpyv and Human Colorectal Cancermentioning

confidence: 99%

Review on the role of the human Polyomavirus JC in the development of tumors

Delbue

Comar

Ferrante

2017

Infect Agents Cancer

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Almost one fifth of human cancers worldwide are associated with infectious agents, either bacteria or viruses, and this makes the possible association between infections and tumors a relevant research issue. We focused our attention on the human Polyomavirus JC (JCPyV), that is a small, naked DNA virus, belonging to the Polyomaviridae family. It is the recognized etiological agent of the Progressive Multifocal Leukoencephalopathy (PML), a fatal demyelinating disease, occurring in immunosuppressed individuals.JCPyV is able to induce cell transformation in vitro when infecting non-permissive cells, that do not support viral replication and JCPyV inoculation into small animal models and non human primates drives to tumor formation. The molecular mechanisms involved in JCPyV oncogenesis have been extensively studied: the main oncogenic viral protein is the large tumor antigen (T-Ag), that is able to bind, among other cellular factors, both Retinoblastoma protein (pRb) and p53 and to dysregulate the cell cycle, but also the early proteins small tumor antigen (t-Ag) and Agnoprotein appear to cooperate in the process of cell transformation.Consequently, it is not surprising that JCPyV genomic sequences and protein expression have been detected in Central Nervous System (CNS) tumors and colon cancer and an association between this virus and several brain and non CNS-tumors has been proposed. However, the significances of these findings are under debate because there is still insufficient evidence of a casual association between JCPyV and solid cancer development.In this paper we summarized and critically analyzed the published literature, in order to describe the current knowledge on the possible role of JCPyV in the development of human tumors.

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“…To date, no conclusive prospective studies supporting a causal association between JCPyV infection and cancer development in humans have been conducted. Several case-control studies, sometimes nested within cohort studies, have been conducted to establish the association between JCPyV seropositivity and specific human tumor types, including colorectal cancer 155 - 161 , lymphoma 162 , 163 , central nervous system tumors 164 165 - 166 , esophageal carcinoma 167 , carcinoma of the bladder 168 , and prostate cancer 169 . These results should be interpreted with caution since anti-JCPyV antibodies may persist for decades, indicating previous exposure to the agent but not viral reactivation.…”

Section: Introductionmentioning

confidence: 99%

Human polyomaviruses and cancer: an overview

Prado¹,

Monezi²,

Amorim³

et al. 2018

Clinics

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The name of the family Polyomaviridae, derives from the early observation that cells infected with murine polyomavirus induced multiple (poly) tumors (omas) in immunocompromised mice. Subsequent studies showed that many members of this family exhibit the capacity of mediating cell transformation and tumorigenesis in different experimental models. The transformation process mediated by these viruses is driven by viral pleiotropic regulatory proteins called T (tumor) antigens. Similar to other viral oncoproteins T antigens target cellular regulatory factors to favor cell proliferation, immune evasion and downregulation of apoptosis. The first two human polyomaviruses were isolated over 45 years ago. However, recent advances in the DNA sequencing technologies led to the rapid identification of additional twelve new polyomaviruses in different human samples. Many of these viruses establish chronic infections and have been associated with conditions in immunosuppressed individuals, particularly in organ transplant recipients. This has been associated to viral reactivation due to the immunosuppressant therapy applied to these patients. Four polyomaviruses namely, Merkel cell polyomavirus (MCPyV), Trichodysplasia spinulosa polyomavirus (TSPyV), John Cunningham Polyomavirus (JCPyV) and BK polyomavirus (BKPyV) have been associated with the development of specific malignant tumors. However, present evidence only supports the role of MCPyV as a carcinogen to humans. In the present review we present a summarized discussion on the current knowledge concerning the role of MCPyV, TSPyV, JCPyV and BKPyV in human cancers.

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Does JC virus have a role in the etiology and prognosis of Egyptian colorectal carcinoma?

Cited by 14 publications

References 34 publications

Prevalence of JC and BK viruses in Patients with Colorectal Cancer: A Systematic Review and Meta- Analysis

Prevalence of JC and BK viruses in Patients with Colorectal Cancer: A Systematic Review and Meta- Analysis

Review on the role of the human Polyomavirus JC in the development of tumors

Human polyomaviruses and cancer: an overview

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