Prevalence of JC and BK viruses in Patients with Colorectal Cancer: A Systematic Review and Meta- Analysis

Shoraka, Hamid Reza; Abobakri, Omid; Tahami, Ahmad Naghibzade; Mollaie, Hamidreza; Bagherinajad, Zohre; Afshar, Reza Malekpour; Shahesmaeili, Armita

doi:10.31557/apjcp.2020.21.6.1499

Cited by 12 publications

(15 citation statements)

References 42 publications

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“…Additionally, JCV infection increased the odds for colorectal adenoma development (6-fold) more than colorectal cancer (4.1-fold). Our findings corroborate the results of recent meta-analyses indicating that the presence of JCV in colorectal tissues increased the odds of colorectal tumors by 4.4 to 4.7 times compared to the absence of the virus [50,51] . In these studies, however, colorectal cancer and adenoma were not looked at individually, and the association of JCV infection with EO-CRC was not assessed.…”

Section: Discussionsupporting

confidence: 91%

Does Human JC Virus Play a Role in the International Variations and Temporal Trends of Early-Onset Colorectal Cancer? A Meta-Analysis

Hamid¹,

Marc-Hern醤dez

Ruíz-Tóvar

2020

Journal of Gastroenterology and Hepatology Research

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The prevalence and incidence trend of early-onset colorectal cancer (EO-CRC) exhibit wide variations across the world, which could be attributed to early-life exposures such as diet and viral infections. We carried out a systematic review and meta-analysis to examine the association between John Cunningham virus (JCV) infection and EO-CRC. Literature was searched for studies comparing the presence of JCV DNA in colorectal cancerous and non-cancerous tissues.Countries where the studies were conducted were categorized into high and low prevalence settings for EO-CRC, and according to the time-weighted average annual per cent change in incidence rates of EO-CRC into rising-trend, stable-trend, and decreasing-trend settings. A total of 19 studies with 3065 participants were included. The metaanalysis showed that JCV increased the odds for colorectal adenoma development (6-fold) more than colorectal cancer (4.1-fold), in comparison to controls. The odds for colorectal tumor development with JCV infection were significantly higher in the high-prevalence settings than in the low-prevalence settings when compared with controls and matched adjacent colorectal tissues. Similarly, the odds for colorectal tumor development trended to be higher in the risingtrend settings than in the stable-trend settings when compared with controls and matched adjacent colorectal tissues; no JCV DNA was detected in the decreasing-trend settings in both cancerous and noncancerous colorectal tissues. These results suggest that JCV is likely involved in early stage of colorectal carcinogenesis, and may play a role in the international variations and temporal trends of EO-CRC in some parts of the world.

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Section: Discussionsupporting

confidence: 91%

Does Human JC Virus Play a Role in the International Variations and Temporal Trends of Early-Onset Colorectal Cancer? A Meta-Analysis

Hamid¹,

Marc-Hern醤dez

Ruíz-Tóvar

2020

Journal of Gastroenterology and Hepatology Research

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“…Herpesviridae HHV7 Oral HHV7 DNA frequently detected in oral cavity cancer [26] HSV (HHV1/2) Oral Higher proportion of HSV-positive oral squamous cell carcinoma in industrialized countries [41] KSHV (HHV8) Kaposi sarcoma In HIV-infected individuals, KSHV infection is associated with Kaposi sarcoma [42] Polyomaviridae BKV Bladder Possible association of BKV with bladder cancer [26] BKV Colorectal Possible association of BKV with colorectal cancer [43,44], however, other studies found no association [16,45] JCV Colorectal…”

Section: Virus Family Virus Cancer Type Observationsmentioning

confidence: 99%

The Roles of the Virome in Cancer

Broecker

Moelling

2021

Microorganisms

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Viral infections as well as changes in the composition of the intestinal microbiota and virome have been linked to cancer. Moreover, the success of cancer immunotherapy with checkpoint inhibitors has been correlated with the intestinal microbial composition of patients. The transfer of feces—which contain mainly bacteria and their viruses (phages)—from immunotherapy responders to non-responders, known as fecal microbiota transplantation (FMT), has been shown to be able to convert some non-responders to responders. Since phages may also increase the response to immunotherapy, for example by inducing T cells cross-reacting with cancer antigens, modulating phage populations may provide a new avenue to improve immunotherapy responsiveness. In this review, we summarize the current knowledge on the human virome and its links to cancer, and discuss the potential utility of bacteriophages in increasing the responder rate for cancer immunotherapy.

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“…JCV T antigen was involved in colorectal carcinogenesis and liver metastasis ( Sinagra et al, 2014 ; Shoraka et al, 2020 ; Vilkin and Niv, 2011 ). Reportedly, JCV T antigen stabilized β-catenin for its nuclear translocation to initiate cancer proliferation and development ( Nosho et al, 2009 ).…”

Section: Discussionmentioning

confidence: 99%

The Oncogenic Roles of JC Virus T Antigen in Breast Carcinogenesis

Zheng

Ying

Cui

et al. 2021

Front. Mol. Biosci.

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Purpose: JC virus (JCV) infects 80–90% of the population and results in progressive multifocal leukoencephalopathy upon immunodeficiency. The study aimed to pathologically clarify the oncogenic roles of T antigen in human breast cancers.Methods: Breast cancer, dysplasia, and normal tissues were examined for T antigen of JCV by nested and real-time PCR. The positive rate or copy number of T antigen was compared with clinicopathological parameters of breast cancer. JCV existence was morphologically detected by immunohistochemistry and in situ PCR. T antigen was examined by Western blot using frozen samples of breast cancer and paired normal tissues.Results: According to nested PCR, the positive rate of breast ductal or lobular carcinoma was lower than that of normal tissue (p < 0.05). T antigen existence was negatively correlated with E-cadherin expression and triple-negative breast cancer (p < 0.05), but positively correlated with lymph node metastasis and estrogen receptor and progestogen receptor expression (p < 0.05). Quantitative PCR showed that JCV copies were gradually decreased from normal, dysplasia to cancer tissues (p < 0.05). JCV T antigen copy number was lower in ductal adenocarcinoma than in normal tissue (p < 0.05), in line with in situ PCR and immunohistochemistry. JCV copies were negatively correlated with tumor size and E-cadherin expression (p < 0.05), but positively correlated with G grading of breast cancer (p < 0.05). Western blot also indicated weaker T antigen expression in breast cancer than normal tissues (p < 0.05).Conclusion: JCV T antigen might play an important role in breast carcinogenesis. It can be employed as a molecular marker for the differentiation and aggressive behaviors of breast cancer.

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Prevalence of JC and BK viruses in Patients with Colorectal Cancer: A Systematic Review and Meta- Analysis

Cited by 12 publications

References 42 publications

Does Human JC Virus Play a Role in the International Variations and Temporal Trends of Early-Onset Colorectal Cancer? A Meta-Analysis

Does Human JC Virus Play a Role in the International Variations and Temporal Trends of Early-Onset Colorectal Cancer? A Meta-Analysis

The Roles of the Virome in Cancer

The Oncogenic Roles of JC Virus T Antigen in Breast Carcinogenesis

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