Does hydrochlorothiazide prevent recurrent urinary tract infection in children with idiopathic hypercalciuria?

Yousefi, Parsa; Firouzifar, Mohammadreza; Cyrus, Ali

doi:10.1016/j.jpurol.2012.09.008

Cited by 8 publications

(13 citation statements)

References 15 publications

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“…In this reaction, vitamin C supplementations maintain the iron and copper atoms and cofactors of the metalloenzymes, in a reduced state. In addition, it is an important antioxidant in the aqueous of the body (15,16). Vitamin C supplementations deficiency reduces cellular immunity and increase duration of some diseases (11,17).…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Ascorbic Acid Supplementation in Relief of Symptoms Due to Febrile Upper Urinary Tract Infection in Children, a Clinical Trial and Hospital Based Study

Yousefichaijan

Goudarzi

Rezagholizamenjany

et al. 2018

Arch Pediatr Infect Dis

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Background: Urinary tract infections (UTIs) as a urological disorder occur in 1% -3% of females and 1% of males. This disease can induce severe complications such as pyelonephritis. Objectives: The current study aimed at evaluating the efficacy of vitamin C supplementation on UTI in children. Methods: The current clinical trial was conducted on 152 female children with UTI admitted to Amir-Kabir hospital, Arak, Iran. The cases were randomly divided, based on blocked groups, into two treatment and control groups of 76 patients. The subjects were matched in terms of age, gender, and clinical signs and symptoms. The control group received only routine treatment of UTI, while the treatment group, in addition to the routine treatment received oral vitamin C supplementation tablet, for a 14-day period. Results: Dysuria, urine incontinence, fever, urinary urgency, and dribbling occurred significantly earlier in vitamin C supplemented individuals than the control ones, while abdominal pain, dimercaptosuccinic acid (DMSA) scan, and recurrent UTI were not different between the two groups. Conclusions: Vitamin C supplementation can control the symptoms of urinary tract infections, including fever, dysuria, urinary urgency, and dribbling urine.

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Section: Introductionmentioning

confidence: 99%

Efficacy of Ascorbic Acid Supplementation in Relief of Symptoms Due to Febrile Upper Urinary Tract Infection in Children, a Clinical Trial and Hospital Based Study

Yousefichaijan

Goudarzi

Rezagholizamenjany

et al. 2018

Arch Pediatr Infect Dis

View full text Add to dashboard Cite

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“…In each group, recurrence of urinary tract infection was 34% (17 cases) which was not statistically significant. Therefore, the results of this study rejected the effect of hypercalciuria treatment in the prevention of infection (17). Therefore, the relationship between these two diseases and their therapeutic decisions requires more precise studies, with the aim of eliminating confounding factors.…”

Section: Discussionmentioning

confidence: 84%

“…Their main function is to inhibit the transfer of sodium chloride in the inferior part of the convoluted tubule (16). Full doses of thiazides cause moderate but persistent diuresis of sodium and chloride that increases the exchange of sodium-calcium in the vascular membrane, thus increasing calcium reuptake from urine and decreasing calcium excretion (16,17).…”

Section: Discussionmentioning

confidence: 99%

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Comparison efficacy and side effects of combined cystone and hydrochlorothiazide with cystone monotherapy in treatment and passage of upper urinary stones; a randomized clinical trial

et al. 2019

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Introduction: Urinary stones are one of the most common and painful diseases of humans after urinary tract infections and prostate diseases. Objectives: The aim of this study was comparing the efficacy and complications of combined cystone and hydrochlorothiazide with cystone monotherapy in the treatment of upper urinary stones. Patients and Methods: In this randomized clinical trial 80 patients older than 15 years old with renal and ureteral stones less than 10 mm after taking informed consent form were allocated randomly in one of two groups. Patients with azotemia, hydronephrosis, bothersome pain and pregnant women were excluded. In the first group, combinations of cystone and hydrochlorothiazide tablets (every 12 hours, two 100 mg cystone and 25 mg hydrochlorothiazide) were prescribed. In the second group, cystone were prescribed as the first group. One month later, patients were followed by kidney, ureter, and bladder x-ray (KUB) and ultrasonography and the success of treatment was determined by changing the size of stones and report of stone passage by the patients. All data were collected and analyzed by SPSS software version 23 and statistical tests. Results: The mean age of the patients in combined and single groups were 48.02±13.72 and 44.15 ± 14.86(P = 0.24) years respectively. The mean size of stone after treatment in two groups was 1.72±0.98 and 1.85±0.78 mm respectively (P=0.53). Regarding efficacy of combined and single group, more than 90% of the patients reported stones passage after the intervention (P=0.06). There were no significant differences in mean blood urea (P=0.38) and serum creatinine (P=0.53) after treatment in two groups. Conclusion: The results of this study showed that combination of cystone and hydrochlorothiazide do not increase the efficacy of cystone in treatment and passage of urinary stones, although in both groups stone passage significantly increased.

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“…In the study of Yousefi et al, treating hypercalciuria was not helpful in preventing repeated UTIs and the author recommended more attention in eliminating confounding factors (9).…”

Section: Discussionmentioning

confidence: 99%

Assessment of idiopathic Hypercalciuria in Girls kids with Infrequent Voiding (Underactive Bladder)

et al. 2017

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Background: Hypercalciuria may be a sign of infrequent voiding; these symptoms may be treated if we get rid of hypercalciuria. Objectives: This paper is intended to get to the prevalence of hypercalciuria in girls (kids) with infrequent voiding. Methods: 80 patients with the index of infrequent voiding, who were admitted to Amir-Kabir hospital of Arak, and 80 children who were admitted without any particular disease just for a laboratory check were studied simultaneously. Urine sample (U/A-U/C), kidney, and bladder sonography was taken from both groups. Results: The prevalence of hypercalciuria in the normal group was 9.64% and in the case group was 53.18% (P = 0.003). Based on the chi-square test, hypercalciuria

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Does hydrochlorothiazide prevent recurrent urinary tract infection in children with idiopathic hypercalciuria?

Cited by 8 publications

References 15 publications

Efficacy of Ascorbic Acid Supplementation in Relief of Symptoms Due to Febrile Upper Urinary Tract Infection in Children, a Clinical Trial and Hospital Based Study

Efficacy of Ascorbic Acid Supplementation in Relief of Symptoms Due to Febrile Upper Urinary Tract Infection in Children, a Clinical Trial and Hospital Based Study

Comparison efficacy and side effects of combined cystone and hydrochlorothiazide with cystone monotherapy in treatment and passage of upper urinary stones; a randomized clinical trial

Assessment of idiopathic Hypercalciuria in Girls kids with Infrequent Voiding (Underactive Bladder)

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