Does HLA‐B*2706 protect against ankylosing spondylitis? A meta‐analysis

Abstract

The human leukocyte antigen (HLA)-B*2706 is a relatively rare subtype of HLA-B27. In contrast to most HLA-B27 subtypes, some studies have reported HLA-B*2706 to be protective against ankylosing spondylitis (AS). A systematic review and a meta-analysis of available studies was performed to investigate the association of HLA-B*2706 with AS. After literature review a random effect meta-analysis was performed. No studies were found comparing the frequency of HLA-B*2706 in AS patients and controls. Meta-analysis of seven studies using HLA-B27-positive AS patients and controls showed a protective effect of HLA-B*2706 on development of AS in HLA-B27 individuals (odds ratio = 0.128, 95% CI = 0.043-0.378, P < 0.001). The results of the meta-analysis of HLA-B*2706 in HLA-B27-positive patients and controls is preliminary evidence of a protective effect of HLA-B*2706 against AS in the population. There is a clear need for additional studies on HLA-B*2706 in AS. Due to the fact that HLA-B*2706 is more or less restricted to Southeast Asia, researchers in this part of the world may have an essential role in performing these studies.

Paraneoplastic Palmar Fasciitis and Polyarthritis Syndrome in a Patient With Advanced Prostate Cancer

“…In most cases of PFPAS, the rheumatologic symptoms preceded the detection of the underlying malignancy, 1,3,5–11,15–18,20,21,23,26,28 whereas in some cases the PFPAS occurred simultaneously with 14,17,24 or after the initial cancer diagnosis. 2,4,6,19,22,29 It may also develop as the first symptom of cancer recurrence or progression (as was the case in our patient). 2,8,12,25,27,30,31 Indeed, in both cases of prostate cancer-related PFPAS, the rheumatologic symptoms appeared at the time of progression to the castration-resistant state.…”

“…Although arthritic symptoms may involve multiple additional joints (as was the case in our patient, thus the term “polyarthritis”), plantar fasciitis is less common and has been reported in only 5 patients. 1,2,17,22,27 The development of symptoms (especially in the palms and hands) is usually rapid, leaving the patient severely disabled in the span of several days or weeks.…”

“…Since that seminal report published 30 years ago, only 48 additional cases of PFPAS have been described in the literature, and these have been associated with a number of different neoplasms, including gynecologic malignancies (ovarian and fallopian tube cancers), 2–16 pancreatic adenocarcinoma, 17–20 non—small cell and small cell lung carcinoma, 3,20–22 breast carcinoma, 23–26 prostate carcinoma, 27 gastric cancer, 28 colon cancer, 20 transitional cell carcinomas of the urinary tract, 6,20,29 carcinoma of unknown origin, 17 and hematologic malignancies 17,30 (Appendix Table 1). …”

New aspects of spondyloarthritis pathogenesis. Part I. Genetic factors and role of HLA-B27 molecules

“…wśród rasy kaukaskiej jest nim allel B*27:05, w populacji śródziemnomor-skiej allel B*27:02, a u Chińczyków allel B*27:04. Allel B*27:09 nie jest czynnikiem ryzyka, a allelowi B*27:06 przypisuje się działanie protekcyjne [8,9]. Podtypy czą-steczek HLA-B27 kodowane przez różne allele różnią się stabilnością i swoistością wiązania peptydów antygenowych, co wyjaśnia, dlaczego tylko niektóre allele są powiązane z ZZSK.…”

HLA-B27-associated uveitis: From pathogenesis to therapy

“…Большинство из них отличаются друг от друга лишь несколькими аминокис-лотами, но считается, что этих отличий достаточно для из-менения свойств молекулы пептида [12,18,19]. При иссле-довании различных популяционных групп было показано, что не все аллели ассоциированы с развитием заболевания, а наличие ряда из них может оказывать даже некоторый «протективный» эффект [19][20][21][22][23][24]. Как уже отмечалось, ост-рый передний увеит развивается не у всех пациентов, стра-дающих СпА.…”