Does gastro-esophageal reflux provoke the myocardial ischemia in patients with CAD?

Dobrzycki, Sławomir; Baniukiewicz, Andrzej; Korecki, Janusz; Bachórzewska−Gajewska, Hanna; Prokopczuk, Przemysław; Musiał, Włodzimierz J.; Kamiński, Karol; Dâbrowski, A

doi:10.1016/j.ijcard.2004.10.018

Cited by 41 publications

(47 citation statements)

References 25 publications

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“…9,10 There also have been a few epidemiological studies exploring the link between GERD and cardiovascular diseases. 11,12 Using the UK General Practice Research Database, Ruigómez et al 11 demonstrated that patients with GERD had an increased risk of subsequent diagnosis of angina.…”

Section: Discussionmentioning

confidence: 99%

Reflux Esophagitis and the Risk of Stroke in Young Adults

Sheu

Kang

Lou

et al. 2010

Stroke

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Background and Purpose-Reflux esophagitis (RE) is the most common manifestation of gastro-esophageal reflux disease with esophageal injury. To the best of our knowledge, there has been no specific study to evaluate the risk of stroke after diagnosis of RE in young adults. This study aims to evaluate the risk of stroke among RE patients aged 18 to 50 years during a 1-year period after diagnosis of RE compared to a cohort of non-RE patients during the same period. Methods-This study used the Taiwan Longitudinal Health Insurance Database 2005. A total of 2340 RE patients were included as the study cohort and 11 700 non-RE patients were included as the comparison cohort. Each patient was individually tracked for 1 year from the index ambulatory visit to identify those in whom stroke developed. Results-Out of the sample of 14 040 patients, 78 patients (0.56%) had strokes develop during the 1-year follow-up period:22 from the study cohort (0.94% of the RE patients) and 56 from the comparison cohort (0.48% of patients without RE).Patients with RE were 1.68-times more likely to have strokes develop (95% confidence interval, 1.03-2.76) than patients in the comparison cohort during the follow-up period after adjusting for patients' medical comorbidities, such as hypertension, diabetes, coronary heart disease, renal disease, heart failure, and hyperlipidemia, as well as their demographic differences, such as the level of urbanization of their communities, monthly income, and geographical location. Conclusions-We conclude that RE is associated with an increased risk of subsequent stroke in young adults. (Stroke.

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Section: Discussionmentioning

confidence: 99%

Reflux Esophagitis and the Risk of Stroke in Young Adults

Sheu

Kang

Lou

et al. 2010

Stroke

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“…This gives an odds ratio of 1.31 which, if true, would provide this investigation with 86% power to detect a similar change. The underlying link between the association of myocardial ischemia and BE has been postulated to be gastroesophageal reflux disease (28). Alternatively, the association may be mediated by other shared risk factors.…”

Section: Discussionmentioning

confidence: 99%

Risk of Mortality and Cancer Incidence in Barrett's Esophagus

Cook

Wild

Everett

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: There are very few prospective follow-up studies of Barrett esophagus (BE) cohorts assessing the risk of extraesophageal cancer incidence or mortality. Such studies are necessary in order to understand the overall risks of cancer and death experienced by patients with BE. Methods: A cohort of 502 patients with BE were identified at Leeds General Infirmary, England. Mortality and cancer incidence information were provided by the Office for National Statistics. Standardized mortality ratios (SMR) and standardized incidence ratios (SIR) were calculated using indirect standardization. Results: All-cause mortality was found to be elevated in patients with BE [SMR, 1.21; 95% confidence interval (95% CI), 1.06, 1.37] and remained so after esophageal cancers were excluded (SMR, 1.16; 95% CI, 1.01-1.32). Increased mortality risks were also found for malignant neoplasms of the esophagus (SMR, 7.26;

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“…That is why it has been described that the treatment of gastroesophagitis has reduced the frequency of angina attacks [3][4][5].…”

Section: Introductionmentioning

confidence: 99%