Proteção da recuperação funcional do miocárdio pelo omeprazol após isquemia-reperfusão em corações isolados de ratos

Gomes, Otoni Moreira; Magalhães, Mônica de Mônico; Abrantes, Rafael Diniz

doi:10.1590/s0102-76382010000300016

Cited by 11 publications

(10 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This was also confirmed in subsequent research with Na + / H + ATPase inhibitors and amiloride cariporida [22,24]. In a recent study [14], it was found a significant protection of omeprazole against ischemia-reperfusion in isolated rat hearts.…”

Section: Discussionsupporting

confidence: 63%

“…The animals underwent a wide-range median thoracotomy and 500 IU of heparin were regularly injected into the right atrium. For safety and quickness in the procedure preparation, the ascending aorta was isolated with the 3-wire technique [14,15]. The first wire pulls and lifts the aortic root to protect the cusps and to prevent ventricular cannulation; the second wire pulls and lifts the cranial (superior) end of the ascending aorta; and the third wire is passed between the first two to tie off the aorta on the cannula after it was inserted.…”

Section: Methodsmentioning

confidence: 99%

“…It was recently proposed and demonstrated the protective effect of omeprazole on induced myocardial ischemia in isolated rat hearts [14], suggesting the effect of this drug by induced preconditioning.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Pantoprazol oferece proteção miocárdica semelhante ao pré-condicionamento isquêmico

Gomes¹,

Magalhães²,

Abrantes³

et al. 2011

Rev Bras Cir Cardiovasc

Self Cite

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 63%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Pantoprazol oferece proteção miocárdica semelhante ao pré-condicionamento isquêmico

Gomes¹,

Magalhães²,

Abrantes³

et al. 2011

Rev Bras Cir Cardiovasc

Self Cite

View full text Add to dashboard Cite

“…Myocardial contractility alterations of isolated hearts of rats, submitted to ischemia and reperfusion with and without administration of the omeprazole was evaluated by Gomes et al51 who concluded that omeprazole administration before ischemia induction significantly protected the myocardium function recovery. Minicucci et al52 analyzed the presence of different patterns of remodeling in a murine model and its functional implications and found that animals that underwent coronary occlusion showed two different patterns of remodeling, neither of which constitute a predictor of ventricular dysfunction.…”

Section: Introductionmentioning

confidence: 99%

A survey of recently published cardiovascular, hematological and pneumological original articles in the Brazilian scientific press

Patel¹,

Caramelli²,

Gomes³

2011

Clinics

View full text Add to dashboard Cite

Recent original scientific contributions published in selected Brazilian periodicals and classifiable under cardiovascular and pulmonary subject categories cover a wide range of sub specialties, both clinical and exprimental. Because they appear in journals with only recently enhanced visibility, we have decided to highlight a number of specific items appeared in four Brazilian journals, because we understand that this is an important subsidy to keep our readership adequately informed. These papers cover extensive sub-areas in both fields.

show abstract

“…[19] Animals were intraperitoneally anesthetized with 100 mg/kg ketamine and 10 mg/kg xylazine. [20]…”

Section: Methodsmentioning

confidence: 99%

Oxytocin ameliorates the immediate myocardial injury in heart transplant through down regulation of the neutrophil dependent myocardial apoptosis

Al-Amran

Shahkolahi

2014

Heart Views

View full text Add to dashboard Cite

Cardiac oxytocin (OT) is structurally identical to that found in the hypothalamus, which thereby indicates that cardiac OT is derived from the same gene and is an active form of OT. The abundance of OT and OT receptors in atrial myocytes shows that, directly and/or via the release of the cardiac hormone atrial natriuretic peptide, OT can regulate the force of cardiac contractions. Previous studies have demonstrated the role of OT in the myocardial inflammatory response. The mechanism by which OT elicits protective myocardial effects in the immediate post-transplantation period is not yet clear, and the role of the early phase inflammatory elements in this mechanism has not yet been studied. As a result, in this study, we have investigated the anti-inflammatory effects of OT on myocardial protection in the immediate post-transplantation period.Methods:Adult male Albino rats were grouped into: Sham, Control, and OT-treated groups. The control and treated groups sustained cervical heterotopic heart transplant. Myocardial injury was assessed by measuring: Plasma cardiac troponin I, myocardial proinflammatory cytokines, and histopathological assessment for score of injury, and degree of apoptosis. Myocardial myeloperoxidase, neutrophil infiltration, and neutrophil chemotactant agents, reactive oxygen species, and reactive nitrogen species formation all were measured in the myocardium after 3 hour of reperfusion to assess the neutrophil-dependant myocardial injury and the mechanism involved.Results:Oxytocin down-regulates the neutrophil chemotactant agents the KC/CXCL1 and MIP-2/CXCL2 which recruit less neutrophil into myocardium, this decrement in myocardial PMN infiltration is associated with less reactive oxygen species and reactive nitrogen species formation in the myocardium after 3 hours of global ischemia reperfusion. These oxytocin-induced down-regulation inflammatory and oxidative processes will end in less myocardial injury through impedance in the post-myocardial ischemia/reperfusion apoptotic process.Conclusion:Oxytocin ameliorates myocardial injury in heart transplant through down-regulation the myocardial inflammatory response, reactive oxygen species, and neutrophil-dependant myocardial apoptosis.

show abstract

Proteção da recuperação funcional do miocárdio pelo omeprazol após isquemia-reperfusão em corações isolados de ratos

Cited by 11 publications

References 15 publications

Pantoprazol oferece proteção miocárdica semelhante ao pré-condicionamento isquêmico

Pantoprazol oferece proteção miocárdica semelhante ao pré-condicionamento isquêmico

A survey of recently published cardiovascular, hematological and pneumological original articles in the Brazilian scientific press

Oxytocin ameliorates the immediate myocardial injury in heart transplant through down regulation of the neutrophil dependent myocardial apoptosis

Contact Info

Product

Resources

About