Does Exposure to Indoor Allergens Contribute to the Development of Asthma and Allergy?

Arshad, Syed Hasan

doi:10.1007/s11882-009-0082-6

Cited by 84 publications

(58 citation statements)

References 61 publications

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“…It is generally accepted that short periods of high exposure are possibly more important than the equivalent "dose" accumulation at a lower exposure over a long time 31) . In addition to the amount of allergen, the exposuresensitization relationship may be modified by some other factors, such as parental heredity, viral infections, and concomitant pollutant exposure 32) . It also has been suggested that the effect of animal allergen is a result of increased levels of endotoxin, which may have dual effects on asthma pathogenesis.…”

Section: Discussionmentioning

confidence: 99%

Study of risk factors for atopic sensitization, asthma, and bronchial hyperresponsiveness in animal laboratory workers

Simoneti

Freitas

Barbosa

et al. 2016

Journal of Occupational Health

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al.: Animal laboratory workers: risks for allergy and asthma associated with sensitization, asthma, or BHR. Conclusion: Exposure to laboratory animals was associated with atopic sensitization. However, we did not find a cutoff allergen concentration that increased the risk for sensitization. Duration of exposure seems to be more relevant to sensitization than concentration of allergens in dust. (J Occup Health 2016; 58: 7−15) Key words: Animal experimentation, Atopy, Bronchial hyperreactivity, Occupational disease Workers exposed to laboratory animals have a high risk of developing allergic reactions 1,2) . Rats and mice are the most common etiology of laboratory animal allergy because they are the most commonly used animals in research 3) . The high prevalence of this condition became evident from epidemiological crosssectional studies conducted in the 1980s 1,4) . Eleven to 44% of individuals who work with laboratory animals have reported allergic symptoms. These symptoms can range from skin reactions, nasal congestion, rhinorrhea, sneezing, and conjunctivitis, to severe asthma. Allergic rhinitis and allergic conjunctivitis symptoms are the most commonly reported symptoms. Among workers who become symptomatic, 4 to 22% have occupational asthma 2) . In a cohort study of 342 laboratory animal workers, quantitative analyses of exposure demonstrated a doseresponse relation between the intensity of exposure to skin symptoms and skin prick tests. Intensity of exposure (divided into 4 categories) was evaluated by quantification of rat urinary aeroallergen. Exposureresponse relations for symptoms were observed among sensitized workers, and for chest and eye/nose symptoms, they were not as clear as for skin symptoms. Two exposure indices were created: one based on the The aim of this estudy was to investigate the influence of allergen exposure levels and other risk factors for allergic sensitization, asthma, and bronchial hyperresponsiveness (BHR) in workers exposed to laboratory animals. Methods: This was a crosssectional study performed at two universities, 123 workplaces with 737 subjects. Dust samples were collected from laboratories and animal facilities housing rats, mice, guinea pigs, rabbits, or hamsters and analyzed by enzyme-linked immunosorbent assay (ELISA) to measure allergen concentrations. We also sampled workplaces without animals. Asthma was defined by both symptoms and BHR to mannitol. The concentrations of allergens were tested for association with a skin prick test, respiratory symptoms, spirometry data, and BHR. This multivariate analysis was performed by using Poisson regression to estimate the relative risk (RR) for the exposed group. Results: Our sample comprised students and workers, with 336 subjects in the nonexposed group and 401 subjects in the exposed group. Sixty-nine subjects (17%) had positive results in the skin prick test for animal allergens in the exposed group; in the nonexposed group, 10 subjects had positive results (3%) (p<0.001). Exposure to laboratory animals over 2.8 years...

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Section: Discussionmentioning

confidence: 99%

Study of risk factors for atopic sensitization, asthma, and bronchial hyperresponsiveness in animal laboratory workers

Simoneti

Freitas

Barbosa

et al. 2016

Journal of Occupational Health

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“…43 This study provided limited but useful information on the contamination of cereal and cereal-based foods with B. tropicalis allergens that carries two risks for a population: first, the sensitization of the general population via long-term ingestion of allergen-contaminated food and second, aggravated manifestations in patients with preexisting allergic disease. 44 Blo t 5 allergen should become a routine allergen considered in the clinical diagnosis of patients who complain of an apparent food allergy. Our result is limited by the small sample size, targeting Blo t 5 allergen only; a lack of a microscopic parasitological examination of the samples; and the study of risk factors that affect food contamination with mites in Egypt.…”

Section: Discussionmentioning

confidence: 99%

Quantitation of Blomia tropicalis Allergen Blo t 5 in Cereal and Cereal-Based Foods Consumed in the Nile Delta, Egypt

Hussein

Elawamy

2015

The American Society of Tropical Medicine and Hygiene

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Abstract. The mite Blomia tropicalis has significant prevalence worldwide. Blo t 5 is a major B. tropicalis allergen that has been associated with sensitization and allergic symptoms in many asthmatic patients. Besides house dust, contaminated foodstuffs are an important source of exposure to B. tropicalis allergens. In this study, a double sandwich enzyme-linked immunosorbent assay (ELISA) using mAb 4D4 and biotinylated mAb 4G9 was done to detect Blo t 5 allergen in different types of raw and processed foods, including wheat, corn, rice, bean, wheat and corn flour, cake, and rusk, which were collected from retail stores in the Nile Delta of Egypt. Out of 88 samples, 38 (43.2%) were positive for Blo t 5 allergen with no significant statistical difference in positivity according to food type. In positive samples, the Blo t 5 concentration ranged from 10 ng/g to 790 ng/g. This study showed that Blo t 5 should be considered as an important allergen that presents a risk to the Egyptian population and should become a routine allergen in the skin prick test to improve the management of allergic disease.

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“…Allergic diseases are common chronic diseases, and their prevalence is increasing in Croatia and in many European countries (6,(15)(16)(17)(18). The geneenvironment interactions have a signifi cant role in the sensitisation and exacerbation of childhood asthma, particularly in urban households (2,3,11,19).…”

Section: Indoor Allergensmentioning

confidence: 99%

“…Exposure to mite allergens Der p 1, and Der f 1 of 2 μg g -1 and 10 μg g -1 of dust has been regarded as a risk factor for sensitisation and asthma, respectively. However, in sensitised individuals with mild asthma, repeated exposure to low allergen level may lead to chronic asthma (18). …”

Section: Threshold Values For Indoor Allergensmentioning

confidence: 99%

Arthropod Allergens in Urban Homes

Prester¹

2012

Archives of Industrial Hygiene and Toxicology

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Does Exposure to Indoor Allergens Contribute to the Development of Asthma and Allergy?

Cited by 84 publications

References 61 publications

Study of risk factors for atopic sensitization, asthma, and bronchial hyperresponsiveness in animal laboratory workers

Study of risk factors for atopic sensitization, asthma, and bronchial hyperresponsiveness in animal laboratory workers

Quantitation of Blomia tropicalis Allergen Blo t 5 in Cereal and Cereal-Based Foods Consumed in the Nile Delta, Egypt

Arthropod Allergens in Urban Homes

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