Does deep sedation impact the results of 48 hours catheterless pH testing?

Korrapati, Vineet; Babich, Jay P.; Balani, Anil R.; Grendell, James H.; Kongara, Kavita

doi:10.3748/wjg.v17.i10.1304

Cited by 6 publications

(7 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This may have been because of the chosen anesthesia protocol as we recently showed that the same sedation using acepromazine and buprenorphine had no significant effect on manometrically measured lower esophageal sphincter pressures compared to the awake state . Similarly, in humans it has been shown that Bravo capsule placement under sedation did not significantly increase the fraction time of abnormal test results when compared to unsedated capsule placement …”

Section: Discussionmentioning

confidence: 95%

“…29 Similarly, in humans it has been shown that Bravo capsule placement under sedation did not significantly increase the fraction time of abnormal test results when compared to unsedated capsule placement. 30,31 Lastly, the reliance of clients to detect clinical signs of GER may vary and not all dogs were continually observed. A study design involving confinement and video recording the dogs' behaviors which can be standardly assessed may be a more accurate method of documenting the relationship between reflux and clinical signs.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Wireless Ambulatory Esophageal pH Monitoring in Dogs with Clinical Signs Interpreted as Gastroesophageal Reflux

Kook

Kempf

Ruetten

et al. 2014

Veterinary Internal Medicne

View full text Add to dashboard Cite

BackgroundAlthough gastroesophageal reflux (GER) often is assumed to be causative for upper gastrointestinal and respiratory signs in dogs, no attempts have been made to verify this assumption.ObjectivesTo monitor esophageal pH with the Bravo pH system in healthy dogs and client‐owned dogs displaying signs commonly attributed to GER.AnimalsSeven healthy and 22 client‐owned dogs.MethodsAfter routine esophagogastroduodenoscopy, radiotelemetric pH capsules were placed in distal esophagus for continuous pH recording. Reflux was defined as single pH measurement <4. At discharge, owners were instructed to press individually predefined clinical sign‐buttons on the receiver whenever indicated. Results between groups were compared using Mann–Whitney U‐test.ResultsThe median (range) number of refluxes in client‐owned and healthy dogs, respectively, was 17 (1–205) and 10 (1–65), the number of refluxes >5 minutes in duration was 1 (0–14), and 1 (0–4), duration of longest reflux (min) was 10 (0–65) and 8 (0–27), and fractional time pH <4 (%) was 0.76% (0.01–6.28), and 0.3% (0–3.1). No differences were found between groups. The median of 7 (1–35) clinical sign‐button pushes were recorded in 21 dogs. Median of 12.5% (2.8% [1/35]–50% [2/4]) reflux‐positive clinical sign‐button pushes was found in 10 dogs with reflux‐positive pushes. Five (22.7%) dogs had increased esophageal acid exposure, and mild esophagitis was noted in 1 dog.Conclusion and Clinical ImportanceDespite evidence of increased GER in some dogs, the clinical sign‐reflux association remained poor. Future investigation should focus on dogs with esophagitis.

show abstract

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Wireless Ambulatory Esophageal pH Monitoring in Dogs with Clinical Signs Interpreted as Gastroesophageal Reflux

Kook

Kempf

Ruetten

et al. 2014

Veterinary Internal Medicne

View full text Add to dashboard Cite

show abstract

“…If monitoring time was 24-h or analysis only 24-h pH data, these patients would have been misdiagnosed. Positive SI was identified in 3 patients out of 14 patients with normal pH data, According to Rome III criteria, these patients should be included in GERD disease [24,25]. In total, extended 48-h pH monitoring increased 9 patients (31.0%) diagnosis of GERD when 24-h pH monitoring data could not make diagnosis [19], but the increased rate was lower than the result with BRAVO pH capsule system.…”

Section: Discussionmentioning

confidence: 99%

“…Wireless pH monitoring systems are favorable for diagnosis of GERD, but also have common disadvantages [25]: proximal esophageal reflux monitoring is not feasible, non-acid reflux can not be evaluated. Multichannel intraluminal impedance-pH (MII-pH) testing [27,28] is a relatively new technique, it can detect non-acidic reflux episodes through changes of impedance in esophageal lumen, especially air reflux episodes when pH data is normal.…”

Section: Discussionmentioning

confidence: 99%

Clinical utility and tolerability of JSPH-1 wireless esophageal pH monitoring system

Liu

Xin

2013

BMC Gastroenterol

View full text Add to dashboard Cite

BackgroundWireless esophageal pH monitoring system is an important approach for diagnosis of gastroesophageal reflux disease (GERD), the aim of this study is to test the tolerability and utility of the first wireless esophageal pH monitoring system made in China, and evaluate whether it is feasible for clinical application to diagnose GERD.MethodsThirty patients from Department of Gastroenterology of The First Affiliated Hospital of Chongqing Medical University who were suspected GERD underwent JSPH-1 pH capsule. The capsule was placed 5 cm proximal to the squamocolumnar junction (SCJ) by endoscopic determination, the data was recorded consecutively for 48 hours. Then all pH data was downloaded to a computer for analysis. The discomforts reported by patients were recorded.Results30 patients were placed JSPH-1 pH capsule successfully and completed 24-hour data recording, 29 patients completed 48-hour data recording. One patient complained of chest pain and required endoscopic removal. No complications and interference of daily activities were reported during data monitoring or follow-up period. 48-hour pH monitoring detected 15 patients of abnormal acid exposure, on day1 detected 9 patients, the difference had statistical significance (P<0.01). Positive symptom index (SI) was identified in 3 patients with normal pH data in both 24-hours. In total, 48-hour monitoring increased diagnosis of GERD in 9 patients.Conclusion48-hour esophageal pH monitoring with JSPH-1 wireless pH monitoring system is safe, well tolerated and effective. It can be feasible for clinical application to diagnose GERD.

show abstract

“…Ob dieses Phänomen durch die Endoskopie und die damit verbundene Sedierung verursacht wird, ist aktuell noch nicht geklärt, erscheint aber wahrscheinlich. Unterstützend berichtet eine Studie, dass sofern die Sedierung nur mit Propofol durchgeführt wird, ein derartiger Messunterschied nicht feststellbar ist[294]. Aufgrund der 2-tägigen Messdauer ist die Sensitivität der kabellosen pH-Metrie verglichen mit der sondenbasierten pH-Metrie höher[237,275].…”

unclassified

Ösophageale Refluxdiagnostik – pH-Metrie, Impedanzmessung, Bilirubin-Messung: Empfehlungen der Deutschen Gesellschaft für Neurogastroenterologie und Motilität und der Arbeitsgruppe Neurogastroenterologie der Deutschen Gesellschaft für Verdauungs- und Stoffwechselkrankheiten

Pehl¹,

Keller

Allescher

et al. 2012

Z Gastroenterol

View full text Add to dashboard Cite

show abstract

Does deep sedation impact the results of 48 hours catheterless pH testing?

Abstract: Patients who received propofol for sedation for EGD with Bravo pH capsule placement did not experience any significant difference in reflux episodes from day 1 to day 2.

Cited by 6 publications

References 11 publications

Wireless Ambulatory Esophageal pH Monitoring in Dogs with Clinical Signs Interpreted as Gastroesophageal Reflux

Wireless Ambulatory Esophageal pH Monitoring in Dogs with Clinical Signs Interpreted as Gastroesophageal Reflux

Clinical utility and tolerability of JSPH-1 wireless esophageal pH monitoring system

Ösophageale Refluxdiagnostik – pH-Metrie, Impedanzmessung, Bilirubin-Messung: Empfehlungen der Deutschen Gesellschaft für Neurogastroenterologie und Motilität und der Arbeitsgruppe Neurogastroenterologie der Deutschen Gesellschaft für Verdauungs- und Stoffwechselkrankheiten

Contact Info

Product

Resources

About