“…Moreover, activation of PPAR and SREBP and their target genes by DHA (EPA) in the model organisms increases with increasing DHA concentration in the range of nearly one order (Yu et al, 2008), and the extent of the effect depends also on the length of the time interval of fatty acid application: in pigs, extent of the expression of genes positively influencing adipogenesis (PPARd, PPARc, FABP, lipoprotein lipase) increased linearly with increasing fattening interval using a diet containing a-linolenic acid (Luo et al, 2009). In human subjects, plasma DHA concentration equilibrated after one month of supplementation, near maximal plasma response was reached with DHA daily doses of 2 g (Arterburn, Hall, & Oken, 2006).…”