The function of porcine PPARγ and dietary fish oil effect on the expression of lipid and glucose metabolism related genes

Yu, Yu-Hsiang; Wu, Shinn-Chih; Cheng, W. T. K.; Mersmann, Harry J.; Shen, Tang‐Long; Ding, Shih‐Torng

doi:10.1016/j.jnutbio.2010.01.006

Cited by 26 publications

(27 citation statements)

References 27 publications

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“…Yet these FAs are known activators of membrane receptors and could regulate inflammation at different cellular levels. Furthermore, LC n-3 PUFAs or their metabolites are potent ligand for transcriptional regulators leading to marked changes in lipid metabolism in skeletal muscle [49,50].…”

Section: Discussionmentioning

confidence: 99%

DHA at nutritional doses restores insulin sensitivity in skeletal muscle by preventing lipotoxicity and inflammation

Capel

Acquaviva²,

Pitois

et al. 2015

The Journal of Nutritional Biochemistry

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Section: Discussionmentioning

confidence: 99%

DHA at nutritional doses restores insulin sensitivity in skeletal muscle by preventing lipotoxicity and inflammation

Capel

Acquaviva²,

Pitois

et al. 2015

The Journal of Nutritional Biochemistry

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“…PUFA are potential ligands for this nuclear receptor, which may be the reason why rats fed PUFA have more adipocytes of different sizes [16]. The PPAR family can also inhibit NF-кß factor transcription, which is also related to inflammation [5].…”

Section: Discussionmentioning

confidence: 99%

Eicosapentaenoic acid/docosahexaenoic acid 1:1 ratio improves histological alterations in obese rats with metabolic syndrome

Taltavull¹,

Muñoz-Cortés²,

Lluís³

et al. 2014

Lipids Health Dis

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BackgroundMarine polyunsaturated fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been associated with improvement in the Metabolic Syndrome (MS). The aim of this study is to evaluate how three fish-oil diets with different eicosapentaenoic acid/docosahexaenoic acid ratios (EPA/DHA ratio) affect the histology of liver, kidney, adipose tissue and aorta in a preliminary morphological study. This work uses an animal model of metabolic syndrome in comparison with healthy animals in order to provide information about the best EPA:DHA ratio to prevent or to improve metabolic syndrome symptoms.Methods35 Wistar rats, as a control, and 35 spontaneously hypertensive obese rats (SHROB) were fed for 13 weeks with 3 different suplemmentation of fish oil containing EPA and DHA ratios (1:1, 2:1 and 1:2, respectively). All samples were stained with haematoxylin/eosin stain, except aorta samples, which were stained also with Verhoeff and van Gieson’s stain. A histological study was carried out to evaluate changes. These changes were statistically analyzed using SPSS IBM 19 software. The quantitative data were expressed by mean ± SD and were compared among groups and treatments using ANOVA with post-hoc tests for parametric data and the U-Mann–Whitney for non-parametric data. Qualitative data were expressed in frequencies, and compared with contingency tables using χ2 statistics.ResultsEPA:DHA 1:1 treatment tended to improve the density and the wrinkling of elastic layers in SHROB rats. Only Wistar rats fed with EPA:DHA 1:1 treatment did not show mast cells in adipose tissue and has less kidney atrophy. In both strains EPA:DHA 1:1 treatment improved inflammation related parameters in liver and kidney.ConclusionsEPA:DHA 1:1 treatment was the most beneficial treatment since improved many histological parameters in both groups of rats.

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“…Therefore, the inhibitory effect of DHA on FoxO1 function observed here may be explained by the competition between FoxO1 and PPARγ for target promoter. It may also due to the fact that DHA is a potent ligand for porcine PPARγ activation [43,44]. However, the underlying mechanism awaits further investigation.…”

Section: Discussionmentioning

confidence: 99%

Docosahexaenoic acid suppresses the expression of FoxO and its target genes

Chen

et al. 2012

The Journal of Nutritional Biochemistry

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The function of porcine PPARγ and dietary fish oil effect on the expression of lipid and glucose metabolism related genes

Cited by 26 publications

References 27 publications

DHA at nutritional doses restores insulin sensitivity in skeletal muscle by preventing lipotoxicity and inflammation

DHA at nutritional doses restores insulin sensitivity in skeletal muscle by preventing lipotoxicity and inflammation

Eicosapentaenoic acid/docosahexaenoic acid 1:1 ratio improves histological alterations in obese rats with metabolic syndrome

Docosahexaenoic acid suppresses the expression of FoxO and its target genes

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