Do sesame seed and its products affect body weight and composition? A systematic review and meta-analysis of controlled clinical trials

Raeisi‐Dehkordi, Hamidreza; Mohammadi, Mohammad; Moghtaderi, Fatemeh; Salehi‐Abargouei, Amin

doi:10.1016/j.jff.2018.08.036

Cited by 15 publications

(10 citation statements)

References 49 publications

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“…In addition, SO decreased body weight and body mass index (BMI), whereas it had no effects on other anthropometric indices. 28 It is worth noting that the results of our previous study examining the effects of dietary CO, SO and SCO (SCO: a blend of the two oils) on adults without any chronic diseases revealed no different effects on body fat and composition. 29 The results of our parent project 30 on other health-related aspects have been reported elsewhere.…”

Section: Introductionmentioning

confidence: 75%

Effects of sesame, canola and sesame‐canola oils on body weight and composition in adults with type 2 diabetes mellitus: a randomized, triple‐blind, cross‐over clinical trial

et al. 2021

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BACKGROUND: Recent investigations have proposed that sesame and canola oils might affect body fat distribution. The present study aimed to examine the effects of sesame, canola and sesame-canola (a blend of sesame and canola oils) oils on body weight and composition in adults with type 2 diabetes mellitus in the context of a randomized, triple-blind, three-way, cross-over clinical trial.RESULTS: Eligible participants were randomized to replace their regular dietary oil with sesame oil (SO), canola oil (CO) and sesame-canola oil (SCO) (with 40% SO and 60% CO). Treatment periods lasted 9 weeks and were separated by 4-week washout periods. Body weight and composition were measured at the beginning, in the middle and at the end of each intervention phase. In total, 93 participants completed the study. After adjustment for confounders, within-period changes were observed following SO and CO intake for body weight (0.34 ± 0.16 kg and 0.33 ± 0.17 kg) and visceral fat (0.13 ± 0.06% and 0.13 ± 0.05%, P < 0.05), respectively. Body mass index was increased within SO intake (0.13 ± 0.05 kg m −2 , P = 0.031). All of the treatment oils resulted in reduced waist circumference and index of central obesity (P < 0.05). A significant difference in change values was observed for visceral fat between SCO (−0.14 ± 0.07%) and SO (0.12 ± 0.08%) treatment periods in females (P = 0.02).CONCLUSION: Sesame and canola oils might lead to a modest favorable body fat redistribution by reducing central adiposity, particularly in females; however, the changes were of little clinical importance.

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Section: Introductionmentioning

confidence: 75%

Effects of sesame, canola and sesame‐canola oils on body weight and composition in adults with type 2 diabetes mellitus: a randomized, triple‐blind, cross‐over clinical trial

et al. 2021

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“…This is mostly due to a sedentary lifestyle, and the consumption of high-fat foods ( Chinnala et al, 2014 ). Obesity is related to a variety of metabolic and non metabolic complications, such as type 2 diabetes, dyslipidemia, athersclerosis, hypertension, and other CVDs ( Chinnala et al, 2014 , Raeisi-Dehkordi et al, 2018 ). The scarcity of synthetic drugs against obesity, with sufficient efficacy and minimum side effects, has prompted researchers to shift to medicinal herbs and natural compounds for the treatment of obesity ( Chinnala et al, 2014 ).…”

Section: Effects Of Sesamin On Obesitymentioning

confidence: 99%

“…The scarcity of synthetic drugs against obesity, with sufficient efficacy and minimum side effects, has prompted researchers to shift to medicinal herbs and natural compounds for the treatment of obesity ( Chinnala et al, 2014 ). It has been reported that foods highly concentrated in antioxidants, such as flaxseeds, cranberry, and green tea may be helpful in the management of obesity, such that high levels of antioxidants may lead to weight loss ( Raeisi-Dehkordi et al, 2018 ).…”

Section: Effects Of Sesamin On Obesitymentioning

confidence: 99%

“…Drugs and natural compounds that posses weight-reducing properties elicit their effects by several mechanisms including suppression of lipogenesis, reduction in fat absorption by the gastrointerstinal tract, and activation of apoptosis in adipocytes ( Raeisi-Dehkordi et al, 2018 ). Pancreatic triacylglycerol lipase (PTL) is a major enzyme responsible for the digestion and absorption of dietary fat.…”

Section: Effects Of Sesamin On Obesitymentioning

confidence: 99%

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Health benefits of sesamin on cardiovascular disease and its associated risk factors

Dalibalta

Majdalawieh

Manjikian

2020

Saudi Pharmaceutical Journal

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Sesamin, a major lignin isolated from sesame ( Sesamum indicum ) seeds and sesame oil, is known to possess antioxidant and anti-inflammatory properties. Several studies have revealed that oxidative stress and inflammation play a major role in a variety of cardiovascular diseases (CVDs). This comprehensive review summarizes the evidence on the effects of sesamin on CVD and its risk factors, principally due to its antioxidant properties. Specifically, this review highlights the mechanisms underlying the anti-hypertensive, anti-atherogenic, anti-thrombotic, anti-diabetic, and anti-obesity, lipolytic effects of sesamin both in vivo and in vitro , and identifies the signaling pathways targeted by sesamin and its metabolites. The data indicates that RAS/MAPK, PI3K/AKT, ERK1/2, p38, p53, IL-6, TNFα, and NF-κB signaling networks are all involved in moderating the various effects of sesamin on CVD and its risk factors. In conclusion, the experimental evidence suggesting that sesamin can reduce CVD risk is convincing. Thus, sesamin can be potentially useful as an adjuvant therapeutic agent to combat CVD and its multitude of risk factors.

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“…tocopherol, lignans, and phytosterols) have been reported to be beneficial in improving cardiovascular risk factors, although some other studies were controversial. 6 - 10 These inconsistent observations have been proposed to be related to the combined effects of genetic and environmental factors (e.g. dietary intake) that justified different individual responses to dietary interventions in general.…”

Section: Introductionmentioning

confidence: 99%

The combined effects of cholesteryl ester transfer protein (CETP) TaqIB gene polymorphism and canola, sesame and sesame-canola oils consumption on metabolic response in patients with diabetes and healthy people

Ramezani‐Jolfaie

Aghaei

Yazd

et al. 2020

J Cardiovasc Thorac Res

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Introduction: Cholesteryl ester transfer protein (CETP) is a key regulating enzyme in the lipid metabolism pathway, and its gene polymorphism may be a candidate for modulating the metabolic responses to dietary intervention. We thus examined whether the effects of the CETP TaqIB polymorphism on metabolic profiles were modified by dietary plant oils. Methods: This is a retrospective analysis of data collected during a randomized triple-blind cross over trial. A total of 95 patients with type 2 diabetes and 73 non-diabetes individuals completed a 9-weekof the intake of sesame, canola and sesame-canola oils. Blood samples were collected at the beginning and at the end of each intervention period for biochemical analysis. Genotyping was done using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: In diabetes patients, B1B1 homozygotes of the CETP TaqIB polymorphism compared with B2 carriers (B1B2 + B2B2) had significantly lower diastolic blood pressure, apoB and apoB: apoA-1,and higher Lp(a) after the intake of sesame-canola oil, as well as lower insulin and HOMA-IR after the intake of sesame oil. There was also a significant effect of genotype on adjusted changes of apoB, apoB: apoA-1, insulin, HOMA-IR and QUICKI. A significant genotype-dietary oils combined effects were observed for diastolic blood pressure, and LDL: HDL, TC: HDL and TG: HDL ratios in diabetes patients. No independent or combined effects of dietary oils and genotypes on outcomes were found in healthy people. Conclusion: There was a modulatory effect of the CETP TaqIB polymorphism on some metabolic traits in response to plant oils in patients with diabetes. Taken together, the intake of sesame-canola and canola oils showed more favorable effects in diabetes patients with B1B1 genotype. Future investigations are needed to confirm these results.

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Do sesame seed and its products affect body weight and composition? A systematic review and meta-analysis of controlled clinical trials

Cited by 15 publications

References 49 publications

Effects of sesame, canola and sesame‐canola oils on body weight and composition in adults with type 2 diabetes mellitus: a randomized, triple‐blind, cross‐over clinical trial

Effects of sesame, canola and sesame‐canola oils on body weight and composition in adults with type 2 diabetes mellitus: a randomized, triple‐blind, cross‐over clinical trial

Health benefits of sesamin on cardiovascular disease and its associated risk factors

The combined effects of cholesteryl ester transfer protein (CETP) TaqIB gene polymorphism and canola, sesame and sesame-canola oils consumption on metabolic response in patients with diabetes and healthy people

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