Do mice genetically selected for resistance to oral tolerance provide selective advantage for Schistosoma mansoni infection?

Machado-Silva, José Roberto; Neves, Renata Heisler; Silva, Luciana Ormond da; Oliveira, Regina Maria Figueiredo de; Silva, Antonio Carlos da

doi:10.1016/j.exppara.2005.04.003

Cited by 4 publications

(2 citation statements)

References 37 publications

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“…There is evidence that the broad genetic variability of different mice species and lineages is closely correlated to host susceptibility and/or resistance to infection (Dajem et al 2008; Alves et al 2016). Genetic background is equally relevant in animal models exposed to dietary interventions, especially considering the heterogeneity in metabolic phenotypes (Machado-Silva et al 2005; Van de Vijver et al 2006). Due to genotype homogeneity and similar phenotypic characteristics, inbred mice present advantages over outbred animals, such as better experimental control and reproducibility of pathological manifestations, especially the immunological responses that mediate host–pathogen interactions (Pérez et al 2014; Pereira et al 2017).…”

Section: Discussionmentioning

confidence: 99%

Could diet composition modulate pathological outcomes in schistosomiasis mansoni? A systematic review of in vivo preclinical evidence

et al. 2018

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Schistosomiasis and malnutrition are often overlapped in poor communities, resulting in disproportionately high mortality rates. Currently, fragmented data make it difficult to define the relationship between diet and schistosomiasis. Thus, we systematically review the preclinical evidence on the impact of diet in Schistosoma mansoni infection. From a structured search, we recovered 27 original articles. All studies used mice and most of them investigated hypoproteic (70.37%), hyperlipidic (22.22%) or vitamin-deficient (7.41%) diets. Diets based on carbohydrate, zinc or milk supplementation were investigated at a reduced frequency (3.70% each). Hypoproteic diets attenuated parasitic load and granulomatous inflammation, but also reduced host resistance to S. mansoni infection, determining higher mortality rates. By stimulating steatohepatitis, parasitic load and granulomatous inflammation, hyperlipidic diets increase organ damage and mortality in infected animals. Although a high-sugar diet and vitamin restriction potentiate and zinc supplementation attenuates S. mansoni infection, the current evidence for these diets remains inconclusive. Analysis of methodological quality indicated that the current evidence is at high risk of bias due to incomplete characterization of the experimental design, diet composition and treatment protocols. From the bias analysis, we report methodological limitations that should be considered to avoid systematic reproduction of inconsistent and poorly reproducible experimental designs.

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Section: Discussionmentioning

confidence: 99%

Could diet composition modulate pathological outcomes in schistosomiasis mansoni? A systematic review of in vivo preclinical evidence

et al. 2018

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“…The use of phenotypically defined animal models may help to elucidate the importance of the host-genetic background in resistance to parasitism and identify the genes involved in the trait (Vasconi et al ., 2008). The comparative analysis of extreme response phenotypes is useful in studies of the host–parasite relationship (Machado-Silva et al ., 2005; McRae et al ., 2014, 2016) and has an important role in evaluating the efficacy and safety of new pharmaceutical devices as therapeutic alternatives for medical and veterinary use.…”

Section: Introductionmentioning

confidence: 99%

Effect of sex and genotype of the host on the anthelmintic efficacy of albendazole microcrystals, in the CBi-IGE Trichinella infection murine model

et al. 2021

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Morphological tegument alterations of adult Schistosoma mansoni, harbored in non anti-helminthic treated, high-immune-tolerogenic and low-inflammatory mice

et al. 2010

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The present study exhibits original results of S. mansoni tegumental alterations due to contact with the immune system of non anti-helminthic treated mice. We compared, by SEM, the tegument of adult worms recovered from strains of mice genetically selected to extreme phenotypes of resistance (TR strain) and susceptibility (TS strain) to egg-albumin oral tolerance (OT). The parasites recovered from TR mice displayed no morphologic alteration, while specimens collected from TS mice presented tubercle swelling with blunted and shortened spines in lower density, increased sensory organelle numbers, fusion and tegumental ridge peeling. These tegument alterations were similar to those described for Artemether or Praziquantel treatment, supporting observations that the host immune system influences the development and function of the tegument of worms harbored in both anti-helminthic treated and non-treated mice. Our results are indicative that the development and function of the worm tegument depend on the immune regulatory capacity of each individual host.

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Do mice genetically selected for resistance to oral tolerance provide selective advantage for Schistosoma mansoni infection?

Cited by 4 publications

References 37 publications

Could diet composition modulate pathological outcomes in schistosomiasis mansoni? A systematic review of in vivo preclinical evidence

Could diet composition modulate pathological outcomes in schistosomiasis mansoni? A systematic review of in vivo preclinical evidence

Effect of sex and genotype of the host on the anthelmintic efficacy of albendazole microcrystals, in the CBi-IGE Trichinella infection murine model

Morphological tegument alterations of adult Schistosoma mansoni, harbored in non anti-helminthic treated, high-immune-tolerogenic and low-inflammatory mice

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