Do Intraoperative Analgesics Influence Breast Cancer Recurrence After Mastectomy? A Retrospective Analysis

Abstract

This retrospective analysis suggests that intraoperative administration of ketorolac decreases the risk of breast cancer relapse compared with other analgesícs.

NSAID analgesic ketorolac used perioperatively may suppress early breast cancer relapse: particular relevance to triple negative subgroup

“…In June 2010, Forget et al reported data from a retrospective disease free survival study of 327 consecutive patients comparing various perioperative analgesics and anesthetics (sufentanil, clonidine, ketorolac, and ketamine) in one Belgian hospital and one surgeon [3].…”

Impact of anesthesia for cancer surgery: Continuing Professional Development

“…65 A retrospective review of breast cancer patients undergoing mastectomy suggested that intraoperative ketorolac use was associated with decreased cancer recurrence. 66 Impact of anesthesia for cancer surgery 1253 RCT -randomized controlled trial. GA = general anesthesia; LA = local analgesia; TIVA = total intravenous anesthesia Impact of anesthesia for cancer surgery 1255…”

“…65 Une étude rétrospective chez des patientes ayant un cancer du sein subissant une mastectomie a suggéré que l'utilisation peropératoire de kétorolac était associée à un taux de récidive moindre du cancer. 66 …”

Effects of Sevoflurane or Propofol on Immune Function in Patients Undergoing Hepatectomy

“…The published studies indicate that the anesthetics could directly inhibit immune function of patients, which is closely related with tumor recurrence (1). Aside from the inhibition of anesthetics on lymphocytes, some reports also suggested that anesthetics had a capability to inhibit growth of tumor cells (2)(3)(4).…”