DNA repair genes polymorphism (XPG and XRCC1) and association of prostate cancer in a north Indian population

Abstract

Prostate cancer is the most commonly diagnosed cancer in men worldwide and is the second leading cause of cancer related mortality. Genetic background may account for the difference in susceptibility of individuals to different diseases and the relationship between genetic polymorphism and some diseases has been extensively studied. There are several common polymorphisms in genes encoding DNA repair enzymes, some of these polymorphisms are reported to result in subtle structural alterations of the repair enzyme and modulation of the repair capacity. The aim of the present study was to analyze the effect of XPG Asp 1104His and XRCC1 Arg309Gln polymorphisms on risk of prostate cancer in north Indian population. Statistically significant increased risk of prostate cancer was observed on individuals that posses His/His genotype of XPG (OR 2.53, 95% CI 0.99-6.56, P = 0.031). In this study 150 prostate cancer diagnosed patients, 150 healthy controls and 150 BPH (benign prostate hyper plasia) were recruited from north Indian population. Moreover, individuals that carried the Gln/Gln genotype of XRCC1 also showed statistically increased risk of prostate cancer (OR 2.06, 95% CI 1.07-4.00, P = 0.033). The Asp/Asp of XPG and Gln/Gln of XRCC1 in combination showed statistically increased risk of prostate cancer in cases (OR 3.29, 95% CI 1.09-10.16, P = 0.032).

Role of DNA Repair-related Gene Polymorphisms in Susceptibility to Risk of Prostate Cancer

“…Our finding is consistent with those of several other studies in Indian population, American population and African Americans (Hyytinen et al, 1999;Hooker et al, 2008;Berhane et al, 2012). However, the significance of XPG rs2296147 polymorphisms in the development of prostate cancer in Chinese population is unclear.…”

“…Previous studies have examined the association between DNA repaired gene polymorphisms and risk of prostate cancer in various populations Hooker et al, 2008;Berhane et al, 2012;Liao et al, 2012;Sobti et al, 2012). However, these results are inconsistent.…”

Polymorphisms of DNA repair-related genes with susceptibility and prognosis of prostate cancer

“…Three previous studies conducted in Indian, Caucasian-American, and African-American populations, respectively, reported associations between the XPG Asp1104His polymorphism and risk of prostate cancer (Hyytinen et al, 1999;Hooker et al, 2008;Berhane et al, 2012). Our findings strongly indicate that polymorphisms in XPG rs2296147 contribute to prostate cancer susceptibility, which is in line with results of previous studies showing that the XPG rs2296147 TT genotype is associated with increased prostate cancer risk.…”

“…Our findings strongly indicate that polymorphisms in XPG rs2296147 contribute to prostate cancer susceptibility, which is in line with results of previous studies showing that the XPG rs2296147 TT genotype is associated with increased prostate cancer risk. Berhane et al (2012) reported that the His/His genotype of XPG was associated with a strongly increased risk of prostate cancer in an Indian population, with an OR of 2.53. Another study conducted in the United States reported that XPG Asp1104His plays an important role in the development of prostate cancer (Hyytinen et al, 1999).…”

“…Previous studies have examined the association between single-nucleotide polymorphisms (SNPs) in DNA repair genes and the risk of prostate cancer in various populations (Hyytinen et al, 1999;Hooker et al, 2008;Berhane et al, 2012). However, the results of these studies are inconsistent due to different populations, case selections, and sample sizes.…”